Am J Transplant, Volume 18, Suppl 3 Archives - Page 138 of 211 - ATC Abstracts

2018 American Transplant Congress
Impact of Direct Acting Antiviral Agents (DAAs) for Hepatitis C Virus (HCV)-Induced Liver Diseases on Registration and Outcome on Waiting List (WL) for Liver Transplant (LT)
C. Antoine,¹ C. Jasseron,¹ F. Conti,² S. Dharancy,³ C. Duvoux,⁴ A. Coilly.⁵
¹Medical and Scientific Department, Agence de la Biomedecine, Agence de la Biomedecine, La Plaine Saint Denis, Saint Denis, France; ²Department of Hepatology, University Hospital La Pitie, Paris, France; ³Department of Hepatology, University Hospital Huriez, Lille, Nord Pas de Calais, France; ⁴Department of Hepatology, University Hospital Henri Mondor, Créteil, Val de Marne, France; ⁵Department of Hepatology, University Hospital Paul Brousse, Villejuif, Val de Marne, France.
2d-generation DAAs have dramatically improved the management of patients with HCV, including patients with advanced diseases. In France, since 2013, DAA have been largely used,…
2018 American Transplant Congress
Serelaxin-Notch1 Signaling Promotes Macrophage M2 Differentiation and Alleviates Hepatocellular Damage in Orthotopic Liver Transplantation: From Mouse-to-Human
S. Kageyama,¹ K. Nakamura,¹ B. Ke,¹ R. Sosa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Background/Aim: We have documented crucial role of macrophage Notch1 signaling in a mouse warm hepatic ischemia-reperfusion injury (IRI) model. However, its clinical relevance or therapeutic…
2018 American Transplant Congress
The Influence of a Conversion to Sirolimus-Based Immunosuppression on Non-Melanomatous Skin Cancer Incidence in Kidney Transplant Recipients over Long Term Follow Up
F. Daly,¹ P. O'Kelly,¹ F. Moloney,² D. Sexton,¹ P. Conlon.¹
¹Department of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland; ²Department of Dermatology, Mater Misericordiae University Hospital, Dublin, Ireland.
Background: The CONVERT trial found a reduced incidence of malignancy amongst renal transplant recipients over 2 years of follow up with a conversion from calcineurin…
2018 American Transplant Congress
Memory T Cell Dysfunction after Pregnancy Alloimmunization Prolongs Transplant Survival
P. Porrett,¹ J. Cohen,² R. Xu,¹ E. Lewis,³ M. Elovitz,³ E. Wherry,⁴ D. Sawinski.²
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Medicine, University of Pennsylvania, Philadelphia, PA; ³OBGyn, University of Pennsylvania, Philadelphia, PA; ⁴Microbiology, University of Pennsylvania, Philadelphia, PA.
Background Pregnancy alloimmunization can preclude donor compatibility and may diminish transplant lifespan. While these consequences may be attributed to immunologic memory responses that endanger an…
2018 American Transplant Congress
CD4⁺ T Cells Are Key Barriers to Tolerance Resistance to Islet Allografts in Autoimmune NOD Mice
A. Burrack,¹ K. Beard,² M. Coulombe,² R. Gill.²
¹Microbiology, Immunology, and Cancer Biology, University of Minnesota, Minneapolis, MN; ²Surgery, University of Colorado Denver, Aurora, CO.
Pancreatic islet allografts are effective for restoring euglycemia in type 1 diabetics (T1D) but are vulnerable to rejection by autoreactive (islet-specific) and/or conventional alloreactive T…
2018 American Transplant Congress
Histone Deacetylase Inhibition Mitigates Limb Ischemia Reperfusion Injury
S. Concors,¹ D. Aufhauser,¹ D. Murken,¹ Z. Wang,¹ G. Ge,¹ T. Bhatti,⁴ W. Hancock,^3,4 M. Levine.^1,2
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Surgery, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Vascular composite allotransplantation (VCA) of the limb involves cold and warm ischemia, further limiting organ availability beyond the constraints of blood type, HLA compatibility,…
2018 American Transplant Congress
Novel Function of TIE2 in Immunoregulation
C. Ghosh, T. Agur, A-.L. Mak, S. Pal, J. Wedel, B. David.
Transplant Research Program, Boston Children's Hospital, Boston, MA.
The immunogenicity of graft microvascular endothelial cells (ECs) has immense biological significance in the modulation of the local intragraft microenvironment. EC may either support Teffector…
2018 American Transplant Congress
Can Immunosuppression Maintenance after Renal Allograft Failure Prevent Further Sensitization?
A. Mena-Gutierrez, K. Alquadan, A. Santos, K. Womer, M. Casey.
University of Florida, Gainesville.
After renal graft failure, retransplantation(ReTx) becomes more difficult due to sensitization to alloantigens. In 2013, our center opened a specialty clinic to maintain immunosuppression(IS) after…
2018 American Transplant Congress
Pre-Donation eGFR, Early Post-Donation eGFR, and Subsequent ESRD Risk in Living Kidney Donors
A. Massie,¹ L. Fahmy,¹ M. Henderson,¹ A. Thomas,¹ J. Snyder,² D. Segev.¹
¹Johns Hopkins, Baltimore; ²SRTR, Minneapolis.
The relationship between predonation eGFR and long-term risk of postdonation ESRD has not been characterized. Moreover, while transplant centers are required to collect postdonation serum…
2018 American Transplant Congress
Accepting a DCD Liver May Improve Patient Survival Compared to Waiting for a Non-DCD Liver
A. Wey,¹ N. Salkowski,¹ J. Lake,² W. Kim,³ B. Kasiske,¹ A. Israni,¹ J. Snyder.¹
¹Scientific Registry of Transplant Recipients, Minneapolis; ²Univ of Minnesota, Minneapolis; ³Stanford University, Palo Alto.
Only ~50% of liver candidates undergo deceased donor transplant; 17% die on the waiting list and 20% are removed from the list as too sick…