Am J Transplant, Volume 18, Suppl 3 Archives - Page 136 of 211 - ATC Abstracts

2018 American Transplant Congress
Using the SRTR Expected Survival Worksheet to Estimate Expected Number of Events
J. Gregg,¹ K. Womer,¹ K. Andreoni.²
¹Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FL; ²Department of Surgery, University of Florida, Gainesville, FL.
The purpose of this effort is to provide transplant administrative and clinical directors with reliable predictions of Scientific Registry of Transplant Recipients (SRTR) risk-adjusted 1-year…
2018 American Transplant Congress
Despite the Growing Impact of the American Opioid Epidemic on Organ Donation, a Small Percentage of Drug Intoxication Deaths Result in Organ Donation
L. Hickman,¹ J. Killian,¹ S. Windham.^1,2
¹Department of Surgery, University of Alabama at Birmingham, Birmingham, AL; ²Alabama Organ Center, Birmingham, AL.
Purpose: This study seeks to understand the regional variation in donations after drug overdose (DO) and quantify the proportion of DO deaths that go on…
2018 American Transplant Congress
In-Situ Tissue-Based Gene Expression Profiling is a Reliable Method to Detect Gene Transcripts in Human Kidney Transplant Biopsies
D. Dobi,¹ J. Henrik,² T. Sigdel,² A. Chen,¹ Z. Laszik.¹
¹Department of Pathology, University of California, San Francisco, San Francisco, CA; ²Department of Surgery, University of California, San Francisco, San Francisco, CA.
Purpose. Validation studies that would enable the clinical application of quantitative in situ tissue-based gene expression profiling in renal transplantation are lacking. In this study,…
2018 American Transplant Congress
Peripheral Blood Immune Response-Related Gene Analysis for Evaluating the Development of Subclinical Antibody-Mediated Rejection
T. Yamamoto,¹ K. Iwasaki,² K. Murotani,³ A. Takeda,⁴ M. Tsujita,⁴ T. Hiramitsu,⁴ N. Goto,⁴ S. Narumi,⁴ Y. Watarai,⁴ K. Uchida,² T. Kobayashi.⁵
¹Xenotransplantation, University of Alabama at Birmingham, Birmingham, AL; ²Kidney Disease and Transplant Immunology, Aichi Medical University, Nagakute, Japan; ³Biostatistics, Aichi Medical University, Nagakute, Japan; ⁴Kidney Center, Nagoya Daini Red Cross Hospital, Nagoya, Japan; ⁵Renal Transplant Surgery, Aichi Medical University, Nagakute, Japan.
Background: Noninvasive methods for the early diagnosis of chronic antibody-mediated rejection (cAMR) are desired for patients with de novo (dn) donor-specific HLA antibody (DSA) because…
2018 American Transplant Congress
Isolation and Profiling of miRNAs from Formalin Fixed Paraffin Embedded Endomyocardial Tissues from Human Heart Transplant Recipients
R. Nog,^1,2 C. Gupta,^1,2 J. Fallon,^1,2 J. Panza,^1,2 N. Haque.²
¹Westchester Medical Center, Valhalla, NY; ²New York Medical College, Valhalla, NY.
Allograft rejection is a common complication post heart transplant (HTx) and can be confirmed by endomyocardial biopsy (EBx) only. There is however an increasing need…
2018 American Transplant Congress
Molecular Classifiers Can Outperform the Flawed Histologic “Gold Standard” on Which They Are Trained
J. Reeve, P. Halloran.
University of Alberta, Edmonton, Canada.
The histologic diagnosis of rejection in organ transplants is known to be an imperfect gold standard. Therefore, it might be assumed that molecular classifiers built…
2018 American Transplant Congress
Cardiac Grafts from Insulin Resistant Donors Trigger a Heightened Immune Response via Excessive Induction of Autophagy
S. Cai,¹ J. Miao,² A. Chandraker.¹
¹Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA; ²Division of Endocrinology, Boston Children's Hospital, Boston, MA.
Background Heart transplantation remains the treatment of choice for many patients with medically refractory heart failure. The use of organs from patients with insulin resistant…
2018 American Transplant Congress
A Pre-Transplant Blood-Based Lipid Signature for Prediction of Antibody-Mediated Rejection in Kidney Transplant Patients
G. Gupta, S. Bobba, D. Contaifer, P. Kimball, A. King, D. Kumar, M. Levy, J. Stern, D. Wijesinghe.
Virginia Commonwealth University, Richmond.
BACKGROUNDThere is a lack of biomarkers for pre-kidney transplant immune risk stratification to avoid over- or under-immunosuppression. Since the circulating lipidome is integrally involved in…
2018 American Transplant Congress
Comparison of Bortezomib in Addition to Rituximab Based Treatment of Acute Antibody Mediated Rejection in Kidney Transplantation
A. Mattiazzi,^1,2 J. Pagan,^1,2 A. Arunachalam,¹ I. De la Cruz Alcantara,¹ J. Revollo,² A. Centeno,² A. Valdes,^1,2 G. Guerra.^1,2
¹Nephrology & Hypertension, University of Miami, Miami, FL; ²Miami Transplant Institute, Jackson Memorial Hospital, Miami, FL.
Purpose:The optimal treatment strategy of acute antibody mediated rejection (AMR) in renal allograft recipients remains undefined. The aim of our study was to compare the…
2018 American Transplant Congress
The Treatment of Antibody-Mediated Rejection in Kidney Transplantation: An Updated Systematic Review and Meta-Analysis
S. Wan,^1,2 T. Ying,^1,2 K. Wyburn,^1,2 D. Roberts,^3,4 M. Wyld,^1,2 S. Chadban.^1,2
¹Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; ²Sydney Medical School, University of Sydney, Sydney, Australia; ³Department of Renal Medicine, Canberra Hospital and Health Services, Canberra, Australia; ⁴Medical School, Australian National University, Canberra, Australia.
Introduction: Current treatment strategies for antibody-mediated rejection (AMR) in kidney transplantation are based on low quality data from a small number of controlled trials. Novel…