Am J Transplant, Volume 18, Suppl 3 Archives - Page 136 of 211 - ATC Abstracts

2018 American Transplant Congress
Genome Wide Non-HLA Alloimmunity Contributes to Graft Loss after Kidney Transplantation
R. Reindl-Schwaighofer, A. Heinzel, A. Kainz, K. Jelencsics, O. Viklicky, G. Böhmig, G. Fischer, B. Keating, R. Oberbauer.
Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria; Department of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; Transplant Institute, University of Pennsylvania, Philadelphia, PA.
BackgroundChronic rejection is the main cause of renal transplant loss after the first year and has mostly been attributed to alloimmune responses against human leukocyte…
2018 American Transplant Congress
Efficacy and Safety of Bleselumab in Kidney Transplant Recipients: A Phase 2, Randomized, Open-Label Study
R. Harland,¹ G. Klintmalm,² S. Jensik,³ H. Yang,⁴ J. Bromberg,⁵ J. Holman,⁶ M. Anil Kumar,⁶ V. Santos,⁶ T. Larson,⁶ X. Wang.⁶
¹University of Arizona, Tucson; ²Annette C. and Harold C. Simmons Transplant Institute, Dallas; ³Rush University, Chicago; ⁴PinnacleHealth Transplant Associates, Harrisburg; ⁵University of Maryland, Baltimore; ⁶Astellas Pharma Global Development, Inc., Northbrook.
Introduction: Bleselumab (ASKP1240) is an anti-CD40 monoclonal antibody currently in development. This phase 2, randomized, open-label study assessed the efficacy and safety of bleselumab in…
2018 American Transplant Congress
Cold Pulsatile Machine Perfusion versus Static Cold Storage in Kidneys from Donation after Circulatory Death: A Multi-Centre Randomised Controlled Trial
D. Summers,^1,2 L. Randle,¹ A-.M. O'Sullivan,³ R. Johnson,² D. Collett,² M. Attia,⁴ N. Ahmad,⁴ M. Clancy,⁵ M. Akyol,⁶ A. Tavakoli,⁷ N. Jamieson,³ A. Bradley,¹ C. Watson.¹
¹Cambridge University, Cambridge, United Kingdom; ²NHS Blood and Transplant, Bristol, United Kingdom; ³Cambridge University Hospitals, Cambridge, United Kingdom; ⁴Leeds Teaching Hospitals, Leeds, United Kingdom; ⁵Queen Elizabeth Hospital, Glasgow, United Kingdom; ⁶Edinburgh University, Edinburgh, United Kingdom; ⁷Manchester University Hospitals, Manchester, United Kingdom.
Introduction:Delayed graft function affects around half of all recipients of donation after circulatory death (DCD) kidneys in the UK and has a significant impact on…
2018 American Transplant Congress
Short- and Long-Term Outcomes of Interventional Radiology Treatment for Vascular Complications Following Living Donor Liver Transplantation: The Efficacy of Stent Placement
S. Mizuno,¹ A. Nakatsuka,² A. Hayasaki,¹ U. Iizawa,¹ H. Kato,¹ Y. Murata,¹ A. Tanemura,¹ N. Kuriyama,¹ Y. Azumi,¹ M. Kishiwada,¹ M. Usui,¹ H. Sakurai,¹ H. Sakuma,² S. Isaji.¹
¹Department of Hepatobiliary Pancreatic Transplant Surgery, Mie University, Tsu, Japan; ²Department of Radiology, Mie University, Tsu, Japan.
Background: Vascular complication is life-threatening when it develops after living donor liver transplantation (LDLT) and interventional radiology (IVR) is a less-invasive therapeutic option comparing to…
2018 American Transplant Congress
As Clear as Mud: Volatility of the Five-Tier Quality Assessment of Kidney Transplant Centers in the United States
J. Schold,¹ K. Andreoni,² A. Chandraker,³ R. Gaston,⁴ J. Locke,⁴ A. Mathur,⁵ T. Pruett,⁶ A. Rana,⁷ L. Ratner,⁸ L. Buccini.¹
¹Cleveland Clinic, Cleveland; ²University of Florida, Gainesville; ³Harvard Medical School, Boston; ⁴University of Alabama at Birmingham, Birmingham; ⁵Mayo Clinic, Phoenix; ⁶University of Minnesota, Minneapolis; ⁷Baylor College of Medicine, Houston; ⁸Columbia University, New York.
Outcomes of patients receiving transplants in the US are systematically aggregated into bi-annual Program-Specific Reports(PSRs) detailing risk-adjusted survival by transplant center. Recently the SRTR issued…
2018 American Transplant Congress
Non-Myeloablative Conditioning with Low-Dose Total Body Irradiation in Place of Cyclophosphamide Induces Mixed Chimerism and Long-Term Immunosuppression Free Allograft Survival without Acute Kidney Injury in HLA Mismatched Kidney Transplantation
T. Kawai,¹ T. Spitzer,¹ T. Oura,¹ N. Torkoff-Rubin,¹ N. Elias,¹ M. Sykes,² R. Colvin,¹ D. Sachs,² A. Cosimi.¹
¹Transplant Center, Massachusetts General Hospital, Boston, MA; ²Center for Translational Immunology, Columbia University, New York, NY.
We have achieved successful induction of long-term immunosuppression (IS) free renal allograft survival in HLA mismatched kidney transplantation using cyclophosphamide (CP) based conditioning and combined…
2018 American Transplant Congress
Results of LITMUS (NCT 02541916): The Liver Immune Tolerance Bio Marker Utilization Study
A. Chruscinski,¹ V. Rojas-Luengas,¹ A. Issacher,¹ J. Luo,⁴ H. Yowanto,⁴ N. Selzner,¹ L. Lilly,¹ R. Smith,¹ E. Renner,¹ J. Zhang,¹ D. Grant,¹ O. Adeyi,¹ H. Atkins,² P. Juni,³ G. Levy.¹
¹Multi Organ Transplant Program, University Health Network, Toronto, ON, Canada; ²The Ottawa Hospital Blood and Marrow Transplant Program, The Ottawa Hospital, Ottawa, ON, Canada; ³Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; ⁴SCIEX, Brea, CA.
Background: Previously we reported a novel biomarker gene set for the identification of tolerance in murine models of rapamycin-induced cardiac tolerance and spontaneous hepatic tolerance.…
2018 American Transplant Congress
Extended Criteria Donors Have Higher Expression of Inflammatory Genes Than Standard Donors
M. Abbud-Filho,^1,2,3 M. Fernandes-Charpiot,^1,2 M. Baptista,^1,2 H. Caldas,^1,2 G. Florim.¹
¹Medicine, Laboratory of Immunology and Experimental Transplantation - LITEX, Medical School of Sao Jose do Rio Preto, Sao Jose do Rio Preto, Sao Paulo, Brazil; ²Transplant, Kidney Transplant Unit, Hospital de Base, FAMERP/FUNFARME, Sao Jose do Rio Preto, Sao Paulo, Brazil; ³Urology and Nephrology Institute, Sao Jose do Rio Preto, Sao Paulo, Brazil.
Background.Changes to an organ occur at the time of brain death where a series of inflammatory modify occur within the organ. Because it is not…
2018 American Transplant Congress
Hyaluronic Acid as Early Biomarker of Graft Loss after Liver Transplantation: A Prospective Study
A. Rostved,¹ S. Ostrowski,² L. Peters,³ J. Lundgren,³ C. Sørensen,¹ H-.C. Pommergaard,¹ J. Hillingsø,¹ A. Rasmussen.¹
¹Department of Surgical Gastroenterology and Transplantation, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; ²Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; ³CHIP, Department of Infectious Diseases, Section 2100, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Introduction: Improved diagnosis and understanding the pathophysiology of early allograft dysfunction is essential to improve the short-term outcome after liver transplantation (LT). Hyaluronic acid (HA)…
2018 American Transplant Congress
Tacrolimus Exposure in Human Proximal Tubule Cells Results in Differentially Increased CTGF Expression in Relation to Pharmacogenetic Variants of CYP3A5 and ABCB1
N. Knops,¹ Y. Ramazani,² B. Van den Heuvel,² R. Goldschmeding,³ T. Nguyen,³ E. Levtchenko,¹ D. Kuypers.⁴
¹Paediatric Nephrology and Solid Organ Transplantation, University Hospitals Leuven, Leuven, Belgium; ²Laboratory of Paediatrics, KU Leuven, Leuven, Belgium; ³Pathology, University Medical Center Utrecht, Utrecht, Netherlands; ⁴Nephrology, University Hospitals Leuven, Leuven, Belgium.
AIM: Clinical studies have demonstrated the importance of genetic variation for tacrolimus disposition and suggested a role in the development of renal fibrosis associated with…