Am J Transplant, Volume 18, Suppl 3 Archives - Page 134 of 211 - ATC Abstracts

2018 American Transplant Congress
Inhibition of IL-1R1 Signaling Delays Costimulation Blockade–Resistant Allograft Rejection by Preventing CD8 TEM Expansion
Y. Liu, Y. Dong, D. Mathews, A. Ghosh, A. Adams.
Department of Surgery, Emory University, Atlanta, GA.
The clinical utilization of Costimulaiton Blockade (CoB) led to improved long-term patient outcomes, but wider adoption of is hampered by increased rates of acute cellular…
2018 American Transplant Congress
Prospective Analysis of EBV+ PTLD Incidence in Pediatric Transplant Recipients in the Modern Era
O. Martinez,¹ S. Krams,¹ M. Lapasaran,¹ S. Boyd,² D. Bernstein,² C. Twist,³ K. Weinberg,² D. Gratzinger,² B. Tan,² B. Armstrong,⁴ D. Ikle,⁴ M. Brown,⁵ M. Robien,⁵ C. Esquivel,¹ The CTOTC-06 Investigators.
¹Surgery/Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford; ²Stanford University School of Medicine, Stanford; ³Roswell Park, Buffalo; ⁴Rho, Chapel Hill; ⁵NIAID/NIH, Bethesda.
Post-transplant lymphoproliferative disorder (PTLD) remains a serious problem in the pediatric transplant population. The Clinical Trials of Organ Transplantation in Children (CTOTC)-06 is an NIAID-sponsored…
2018 American Transplant Congress
Mechanisms of Vascularized Bone Marrow Graft Protection of Vascularized Composite Allografts
E. Buckingham, N. Shockcor, W. Hassanein, C. Drachenberg, A. Nam, S. Bartlett, R. Barth.
Surgery, University of Maryland, Baltimore, MD.
Background Co-transplantation of vascularized bone marrow (VBM) promotes vascularized composite allograft (VCA) survival with standard immunosuppression in a non-human primate (NHP) model. We investigated mechanisms…
2018 American Transplant Congress
Endoplasmic Reticulum Stress Sensor IRE1α Deficiency Promotes Infiltrating Macrophage Polarization and Induces Long-Term Renal Allograft Acceptance in Mice
L. Qiu,¹ J-.J. Wang,¹ X. Yeap,¹ D. Fang,² J. Zhang.¹
¹Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL; ²Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Objective: Macrophage is involved in the pathogenesis of I/R injury and allograft rejection. However, the mechanisms underlying this is vastly unknown. This study aims to…
2018 American Transplant Congress
Effects of IdeS on HLA-SAB, C1q-SAB and CDC-XM
S. Järnum,¹ A. Runström,¹ L. Winstedt,¹ T. Lorant,² C. Kjellman.¹
¹Hansa Medical AB, Lund, Sweden; ²Department of Surgical Sciences, Section of Transplantation Surgery, Uppsala, Sweden.
IgG degrading enzyme of Streptococcus pyogenes (IdeS) cleaves human IgG in two steps, first cleaving one of the heavy chains resulting in a single-cleaved IgG…
2018 American Transplant Congress
New Onset Diabetes after Kidney Transplant: Comparisons of Risks Associated with Various Steroid-Containing Calcineurin Inhibitor and Sirolimus Regimens
A. Santos, Jr.,¹ M. Casey,¹ K. Alquadan,¹ X. Wen,² C. Chen,³ A. Gutierrez-Mena,¹ K. Womer.¹
¹College of Medicine, Univ. of Florida, Gainesville, FL; ²College of Pharmacy, Univ. of Rhode Island, Kingston, RI; ³College of Pharmacy, Univ. of Florida, Gainesville, FL.
INTRODUCTION: We aimed to examine the risk of new onset diabetes after transplant (NODAT) associated with the following maintenance immunosuppression regimens in kidney transplant recipients…
2018 American Transplant Congress
Deceased Pediatric Donor Livers: How Current Policy Drives Allocation and Transplantation
E. Hsu,² J. Ge,¹ J. Bucuvalas,³ J. Lai.¹
¹UC-San Francisco, San Francisco, CA; ²Seattle Children's Hospital, Seattle, WA; ³Cincinnati Children's Hospital, Cincinnati, OH; ⁴University of California San Francisco, San Francisco, CA.
Background:The current liver allocation algorithm for livers from deceased pediatric (<18y; “pedi“) donors prioritizes adults listed locally/regionally over children listed nationally. We sought to understand…
2018 American Transplant Congress
Obesity is Not Associated with Worse Outcomes for Type 2 Diabetic Simultaneous Pancreas-Kidney (SPK) Transplant Recipients
R. Forbes, S. Niederhaus, A. Fox, J. Fridell, P. Abrams, O. Olaitan, F. Kandeel, R. Urban, M. Curry, J. Odorico.
Pancreas T2D Subcommittee, UNOS, Richmond.
BACKGROUND: Per current SPK allocation policy, Type 2 Diabetic (T2D) candidate waiting time is contingent on a body mass index (BMI, kg/m2) less than or…
2018 American Transplant Congress
Legal Status, Criminal History, and Substance Use in Listing Decisions
G. Lee, A. Wall, J. Maldonado, D. Magnus.
School of Medicine, Stanford University, Stanford, CA; Stanford University Medical Center, Stanford, CA.
Background: Psychosocial criteria constitute absolute and relative contraindications to listing, which can bar patients from access to organ transplantation at a program. Refusing to list…
2018 American Transplant Congress
Single-Cell Analysis of Graft Infiltrating T-Cells in Cardiac Allograft Vasculopathy
M. Habal, A. Myung, H. Yan, S. Rao, S. Lin, P. Colombo, C. Marboe, S. Restaino, A. Han, M. Farr, E. Zorn.
Medicine, Columbia University Medical Center, New York, NY.
Background: Cardiac allograft vasculopathy (CAV) remains a leading cause of death after heart transplant.T-cells are thought to play a central role, yet the mechanism by…