Am J Transplant, Volume 18, Suppl 3 Archives - Page 130 of 211 - ATC Abstracts

2018 American Transplant Congress
Comprehensive Validation of Different Clinical Prediction Models on Short- and Long-Term Outcome Following Orthotopic Liver Transplantation
J. Boecker,¹ Z. Czigany,¹ J. Bednarsch,¹ I. Amygdalos,¹ F. Meister,¹ D. Morales Santana,¹ W. Schoening,¹ T. Ulmer,¹ M. Krebbers,¹ G. Koek,¹ D. Kroy,² F. Tacke,² C. Trautwein,² U. Neumann,¹ G. Lurje.¹
¹Department of Surgery and Transplantation, University Hospital RWTH, Aachen, Germany; ²Department of Internal Medicine III, University Hospital RWTH, Aachen, Germany.
Background: Organ shortage remains a major problem in orthotopic liver transplantation (OLT). An optimal utilization of the donor pool with better prediction of outcome is…
2018 American Transplant Congress
Liver Transplantation for Severe Alcoholic Hepatitis: Is Early Always Necessary?
T. Wu,¹ N. Nissen,² C. Galloway,² A. Klein,² T. Tran,¹ W. Ayoub,¹ M. Noureddin,¹ I. Kim,² T. Todo,² V. Sundaram.¹
¹Department of Medicine and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Department of Surgery and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Aim: Prior studies have demonstrated liver transplantation (LT) as a viable option for patients with severe alcoholic hepatitis (AH) who fail steroid treatment. These studies…
2018 American Transplant Congress
Prevalence and Persistence of Cardiovascular Risk Factors and Subclinical Vascular Damage in Patients after Pediatric Lung Transplantation
M. Onnen,¹ N. Memaran,¹ B. Borchert,¹ R. Blöte,¹ R. Sugianto,¹ C. Müller,² A. Melk.¹
¹Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany; ²Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
In adults undergoing solid organ transplantation, cardiovascular (CV) disease causes a high level of morbidity and mortality. Children after lung transplantation (Lu-Tx) are prone to…
2018 American Transplant Congress
Lymph Node Stromal Laminins Modulate the Dynamic Balance of the Treg/Th17 Axis
L. Li, T. Simon, W. Piao, Y. Xiong, V. Saxena, T. Zhang, C. Wagner, J. Bromberg.
University of Maryland, Baltimore, MD.
Background: Tolerance and immunity are associated with differential expression of lymph node (LN) stromal laminins α4β1γ1 (411) and α5β1γ1 (511), respectively, which determine how alloreactive…
2018 American Transplant Congress
Clinical Trials and Electronic Health Records
J. Chen, S. Bhattachrya, M. Sirota, M. Sarwal, A. Butte.
Institute for Computational Health Sciences, University of California San Francisco, San Francisco; Deaprtment of Surgery, University of California San Francisco, San Francisco.
Background. Ethnic and gender disparities in solid organ transplantation (tx) have social and clinical implications.General disparities for donor access and complications within clinical-trial, national and…
2018 American Transplant Congress
CMV-Specific CD8+ T-Cell Immune Competence Score as Predictor of Outcome for CMV Infection after Transplantation
A. Meesing,¹ R. Abraham,² R. Razonable.¹
¹Division of Infectious Diseases, Mayo Clinic, Rochester, MN; ²Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Introduction: Control of cytomegalovirus (CMV) infection after solid organ transplantation (SOT) requires a functional immune system. We assessed the utility of a flow cytometric assay…
2018 American Transplant Congress
Daptomycin Minimum Inhibitory Concentration (MIC) of Vancomycin Resistant Enterococcal (VRE) Blood Isolates Correlates with Allograft Failure in Orthotopic Liver Transplant (OLT) Recipients
R. Lee,¹ G. Haidar,² J. Lewis,³ S. Arif,⁴ J. Hand,⁵ E. Holaday,⁶ H. Clauss,⁶ J. Goldman,⁷ A. Nellore.¹
¹University of Alabama at Birmingham, Birmingham, AL; ²University of Pittsburgh Medical Center, Birmingham, AL; ³University of Virginia, Charlottesville, VA; ⁴Duke University, Durham, NC; ⁵Oschner Medical Center, New Orleans, LA; ⁶Department of Internal Medicine, Temple University, Philadelphia, PA; ⁷Temple University, Philadelphia, PA; ⁸Swedish Medical Center, Seattle, WA.
Background: Enterococci are one of the leading causes of nosocomial infection in after OLT. Unfortunately, treatment options for enterococci that are resistant to first-line agents…
2018 American Transplant Congress
Isavuconazole – The Real-World Use Experience
H. Hassouna, V. Athans, K. Brizendine.
Cleveland Clinic Foundation, Cleveland, OH.
Isavuconazole (ISV) is a new triazole approved for treatment of mucormycosis and aspergillosis. Data on its effectiveness outside clinical trials and in patients receiving prior…
2018 American Transplant Congress
BLyS^-/- Rats to Prevent Alloantibody Production
N. Bath,¹ B. Verhoven,¹ N. Wilson,¹ S. Reese,² L. Coons,¹ S. Panzer,² A. Djamali,² R. Redfield.¹
¹Surgery, University of Wisconsin, Madison, WI; ²Medicine, University of Wisconsin, Madison, WI.
Introduction: Antibody mediated rejection (AMR) is a major cause of kidney allograft failure. APRIL (A Proliferation Inducing Ligand) and BLyS (B Lymphocyte Stimulator) are two…
2018 American Transplant Congress
Rhesus-Specific Anti-Thymocyte Globulin as an Adjuvant to Costimulatory-Blockade-Based Immunotherapy
M. Mulvihill,¹ B. Ezekian,¹ Q. Gao,¹ K. Samy,¹ R. Davis,¹ F. Leopardi,¹ A. Belli,² W. Flores,² A. Buzby,² K. Reimann,² B. Collins,¹ A. Kirk.¹
¹Department of Surgery, Duke University, Durham, NC; ²MassBiologics, University of Massachusetts Medical School, Boston, MA.
Background Belatacept targets de novo alloimmune responses with minimal off target effects in renal transplantation, though adjuvant therapy is required to control costimulation-blockade resistant rejection…