ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Liver Transplantation Post Gastric Bypass: Surgical Complications and Outcomes

    A. Vijay, A. Nigam, R. Girlanda, A. Kroemer, J. Hawksworth, C. Matsumoto, T. Fishbein.

    Transplant Surgery, Medstar Georgetown Transplant Institute, Washington, DC.

    Introduction: Liver transplantation in patients with prior gastric bypass poses a unique challenge and may increase the risk of complications.Aim: To characterize surgical complications in…
  • 2018 American Transplant Congress

    Identifying Patients with CPRA>99.95% Likely to Be Offered Deceased Donor Kidneys

    R. Parsons, S. Bumb, H. Decker, R. Bray, H. Gebel.

    Emory Transplant Center, Atlanta, GA.

    The implementation of the new kidney allocation system and priority of kidneys for cPRA=100% subjects revealed a hierarchy difference in allocation to patients with cPRA=99.45%-100%.…
  • 2018 American Transplant Congress

    GDF15 Preventing Renal Ischemia Reperfusion Injury

    C. Zhu,1,2 A. Patel,1 Y. Su,1,2 J. Jiang,1 D. Lian,1 A. Sener,1 W. Min,1 P. Luke,1 D. Quan,1 K. Liu,2 X. Zheng.1

    1University of Western Ontario, London, ON, Canada; 2Jilin University, ChangChun, China.

    Rationale: Ischemia reperfusion (I/R) injury still remains one of main causes of early renal dysfunction in kidney transplantation. There are no effective treatments for preventing…
  • 2018 American Transplant Congress

    mTORC2 Deficiency in CD11c+ dendritic Cells Promotes Acute Kidney Injury

    H. Dai,1,2 A. Watson,1 D. Fantus,1 L. Peng,2 A. Thomson,1 N. Rogers.1

    1Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh; 2Department of Urological Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, China.

    Introduction: The role of the mammalian/mechanistic target of rapamycin (mTOR) in the pathophysiology of renal ischemia-reperfusion injury (IRI) is poorly characterized; furthermore, the influence of…
  • 2018 American Transplant Congress

    Five-Year Outcomes after Randomized Treatment by Rituximab in Early Acute Antibody-Mediated Rejection in Renal Transplantation: Long Term Outcomes of the RITUX ERAH Study

    E. Bailly,1 G. Blancho,2 S. Ville,2 E. Morelon,3 J. Bamoulid,4 S. Caillard,5 V. Chatelet,6 P. Malvezzi,7 J. Tourret,8 V. Vuiblet,9 D. Anglicheau,10 D. Bertrand,11 P. Grimbert,12 F. Haidar,13 M. Hazzan,14 N. Kamar,15 P. Merville,16 C. Mousson,17 V. Pernin,18 C. Pouteil-Noble,19 R. Purgus,20 J. Sayegh,21 P. Westeel,22 M. Büchler.1

    1University Hospital, Tours, France; 2Institut de Transplantation-Urologie-Néphrologie, Nantes, France; 3University Hospital, Lyon Edouard Herriot, France; 4University Hospital, Besançon, France; 5University Hospital, Strasbourg, France; 6University Hospital, Caen, France; 7University Hospital, Grenoble, France; 8Pitié Salpêtrière Hospital, APHP, Paris, France; 9University Hospital, Reims, France; 10Necker Hospital, APHP, Paris, France; 11University Hospital, Rouen, France; 12Mondor Hospital, APHP, Paris, France; 13Territorial Hospital, Noumea, France; 14University Hospital, Lille, France; 15University Hospital, Toulouse, France; 16University Hospital, Bordeaux, France; 17University Hospital, Dijon, France; 18University Hospital, Montpellier, France; 19University Hospital, Lyon Sud, France; 20University Hospital, Marseille, France; 21University Hospital, Angers, France; 22University Hospital, Amiens, France.

    Background The place of rituximab in the treatment of acute antibody-mediated rejection (ABMR) is still controversial. The French multicenter double-blind, placebo-controlled RITUX ERAH study included…
  • 2018 American Transplant Congress

    The ATHENA Study: 12 Months Safety and Efficacy Data from Everolimus Combined with Tacrolimus or Cyclosporine Compared to a Standard Tacrolimus-Mycophenolate Regimen in De Novo Kidney Transplant Patients

    B. Suwelack,1 C. Sommerer,1 D. Dragun,1 O. Witzke,1 C. Hugo,1 N. Kamar,2 P. Merville,2 A. Hauser,1 P. Schenker,1 M. Junge,3 B. Nashan,1 F. Thaiss.1

    1Athena Study Group, Germany; 2Athena Study Group, France; 3Novartis, Pharma, Germany.

    The ATHENA study was set up to compare efficacy and safety of everolimus [EVR] combined with tacrolimus [TAC] or cyclosporine A [CyA] vs. a mycophenolic…
  • 2018 American Transplant Congress

    Factors Related to Suboptimal Recovery of Renal Function after Living Donor Nephrectomy

    S. Nishida, K. Kinoshida, K. Tanaka, Y. Hidaka, S. Hamanoue, C. Kawabata, M. Toyoda, A. Inadome, S. Uekihara, S. Yamanaga.

    Japanease Red Cross Kumamoto Hospital, Kidney Center, Kumamoto, Japan.

    Introduction:Renal function of the living donor usually recovers to 60~70 percent of baseline function by compensatory hypertrophy mechanism. However, the degree of this compensatory hypertrophy…
  • 2018 American Transplant Congress

    Opiate Use Trends after Liver Transplantation and the Factors Associated with Post-Transplant Opiate Dependence

    M. Siddiqui,1 R. Kaur,1 S. Dhoop,2 N. Sulejmani,1 R. Salgia.1

    1Henry Ford Hospital, Detroit, MI; 2Wayne State University SOM, Detroit, MI.

    AimsOur study aims to determine predictive factors leading to post-liver transplant (LT) opioid dependence.MethodsA retrospective chart review was conducted including LT recipients from July 2013-June…
  • 2018 American Transplant Congress

    CD8+ Tissue Resident Memory T Cells Are Key Effector Cells in Intestinal Transplantation Patients with GvHD

    O. Aguirre, B. Houlihan, A. Karabala, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer.

    Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.

    A. As the pathophysiologic role of Tissue Resident Memory T Cells (TRM) in intestinal transplantation (ITx) is unknown, this study aims to test the hypothesis…
  • 2018 American Transplant Congress

    VLA-4 Blockade Inhibits Early Endogenous Memory CD8 T Cell Infiltration into Higher Risk Cardiac Allografts and Donor-Reactive T Cell Priming

    S. Miyairi,1 S. Iida,2 H. Tsuda,1 W. Baldwin III,1 K. Tanabe,2 R. Fairchild.1

    1Immunology, Cleveland Clinic, Cleveland, OH; 2Urology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan.

    Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts within 24 hrs after graft reperfusion in mice. Our recent studies indicate that prolonged cold ischemic…
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