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American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Chronic Rejection: Risk Factors, Clinical Presentation and Outcome in Pediatric Liver Transplant Recipients: A Single Center Experience

    T. Miloh, A. Cheng, D. Schady, R. Himes, K. Mysore, K. Hosek, J. Goss.

    Texas Children's Hospital, Baylor College of Medicine, Houston, TX.

    Chronic rejection (CR) is the leading indication for long term graft loss. We discuss our centers' experience with CR diagnosis and management. Method: Electronic medical…
  • 2018 American Transplant Congress

    Analysis of Cost Effectiveness of Treatment for Acute Antibody-Mediated Rejection

    C. McDermott, K. Carsky, P. Ferrin, A. Gaines, D. Chernobylsky, M. Killackey, A. Paramesh, R. Zhang, J. Buell.

    Tulane University School of Medicine, New Orleans, LA.

    Purpose: Because AMR can be a risk factor for graft loss, the expense created by AMR treatment may be subject to scrutiny in patients who…
  • 2018 American Transplant Congress

    Measles and Varicella Vaccination Status and Evidence of Immunity during Solid Organ Pre-Transplantation Evaluation

    H. Daniels, C. Saracusa, S. Worley, B. Gonzalez.

    Pediatric Infectious Diseases, Cleveland Clinic, Cleveland, OH.

    Background: Ensuring complete vaccination is important during a pre-transplant evaluation (PTE), especially for live viral vaccines which are generally contraindicated after transplant. After one dose…
  • 2018 American Transplant Congress

    Providing Transplant Candidates with Guidance about Differences in Acceptance Criteria across Programs

    C. Schaffhausen,1,4 M. Bruin,3 S. Chu,3 A. Matas,5 J. Lake,6 W. Kim,4,7 S. Biggins,8 J. Snyder,2,4 B. Kasiske,1,4 A. Israni.1,2

    1Department of Medicine, Hennepin County Medical Center (HCMC), University of Minnesota (UMN), Minneapolis, MN; 2Department of Epidemiology and Community Health, UMN, Minneapolis, MN; 3College of Design, UMN, Minneapolis, MN; 4Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN; 5Department of Surgery, UMN, Minneapolis, MN; 6Division of Gastroenterology, Hepatology, and Nutrition, UMN, Minneapolis, MN; 7Division of Gastroenterology and Hepatology, Stanford University, Palo Alto, CA; 8Division of Hepatology, University of Washington, Seattle, WA.

    The Scientific Registry of Transplant Recipients (SRTR) provides federally mandated program-specific reports (PSR) to the public. Candidate acceptance criteria vary widely across programs for many…
  • 2018 American Transplant Congress

    Decreased Expression of Pro-Carcinogenic Genes Following Tacrolimus to Sirolimus Conversion in Liver Transplant Recipients

    M. Bhat,1 E. Pasini,1 C. Baciu,1 S. Kurian,2 J. Levitsky.3

    1Multi Organ Transplant Program, University Health Network, Toronto, Canada; 2Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA; 3Division of Gastroenterology & Hepatology, Department of Medicine, Northwestern University, Chicago.

    Long-term survival post-transplant is significantly impacted by malignancy. mTOR-inhibitors (mTORis) have anti-neoplastic properties and are associated with a decreased incidence of certain malignancies compared to…
  • 2018 American Transplant Congress

    AMD3100 (Plerixafor) as a Single-Dose Stem Cell Mobilizing Agent in Vascularized Composite Tissue Allograft (VCA) Transplantation in a Canine Model

    B. Swearingen,1,2 S. Graves,2,3 R. Storb,2,3 D. Mathes.1,2

    1Surgery; Division of Plastic and Reconstructive Surgery, University of Colorado School of Medicine, Aurora, CO; 2Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; 3Medicine, University of Washington Medical Center, Seattle, WA.

    PURPOSE:Vascularized Composite Allograft (VCA) transplantation is a clinical reality but limited by chronic immunosuppression and rejection. Current clinical tolerance protocols rely on recipient conditioning and…
  • 2018 American Transplant Congress

    Role of Calcium/Calmodulin Kinase IV on Podocyte Function in Transplant Glomerulopathy

    R. Bhargava, K. Maeda, A. Ferreti, M. Pavlakis, G. Tsokos.

    Beth Israel Deaconess Medical Center, Boston.

    Background : Transplant glomerulopathy(TG) a histological manifestation of chronic antibody mediated rejection and a major cause of late allograft loss. It is well accepted that…
  • 2018 American Transplant Congress

    Functional Fc Gamma Receptor Gene Polymorphisms and Donor-Specific Antibody-Triggered Transplant Injury

    M-.L. Arnold,1 A. Kainz,2 F. Eskandary,2 N. Kozakowski,3 M. Wahrmann,2 H. Haslacher,4 R. Oberbauer,2 A. Heilos,5 B. Spriewald,6 L. Hidalgo,7 P. Halloran,8 G. Bohmig.2

    1Department of Internal Medicine 3, Friedrich-Alexander University, Erlangen-Nuremberg, Germany; 2Department of Medicine III, Medical University of Vienna, Vienna, Austria; 3Department of Pathology, Medical University of Vienna, Vienna, Austria; 4Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria; 5Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria; 6Department of Internal Medicine 5, Friedrich-Alexander University, Erlangen-Nuremberg, Germany; 7Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; 8Alberta Transplant Applied Genomics Centre, ATAGC, University of Alberta, Edmonton, AB, Canada.

    Fc-dependent effector mechanisms may play an important role in antibody-mediated rejection (ABMR). Distinct gene polymorphisms may determine the function of Fc gamma receptors (FcγR), potentially…
  • 2018 American Transplant Congress

    Exploring the Viability of Kidneys Discarded in the US: A Comparison of Kidney Utilization Patterns and Outcomes in the US and France

    O. Aubert, P. Reese, M. Raynaud, D. Viglietti, C. Loheac, N. Kamar, M. Delahousse, C. Legendre, D. Glotz, C. Lefaucheur, A. Loupy.

    Paris Translational Center for Organ Transplantation, Paris, France.

    Approximately 2,000 donated kidneys are discarded in the US each year. Some transplant leaders have questioned the viability of these lost organs, while others suggest…
  • 2018 American Transplant Congress

    National Outcomes of Donor and Recipient Sex Mismatch in Kidney Transplantation

    J. Buggs,1 L. Wang,3 R. Liu,3 E. Rogers,2 V. Bowers.1

    1Transplant Surgery, Tampa General Medical Group, Tampa General Hospital, Tampa, FL; 2Transplant Research, Tampa General Hospital, Tampa, FL; 3Molecular Pharmacology & Physiology, University of South Florida, Tampa, FL.

    Introduction: Gender Outcomes remain controversial in solid organ transplantation.Aim: The study aim was to evaluate the outcomes of sex mismatched donors and recipients where a…
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