2018 American Transplant Congress
One-Pump versus Two-Pump Normothermic Ex Vivo Perfusion Machines in Discarded Human Livers
Transplant Surgery, Cleveland Clinic, Cleveland.
Introduction:Physiologic flows and pressures need to be provided by the ex vivo liver perfusion device. We hypothesized that the 1-pump designed machines would provide the…2018 American Transplant Congress
Deceased Donor Urinary Biomarker Signature and the Effectiveness of Peritransplant Lymphocyte Depletion on Early Renal Allograft Function
Purpose: Delayed graft function (DGF) is associated with increased allogaft immunogenicity and decreased long-term survival. We hypothesized that high levels of donor urinary biomarkers for…2018 American Transplant Congress
Are Donation after Cardiac Death (DCD) Kidneys Unsuitable for Pediatric Recipients?
Introduction: Despite the fact that the number of pediatric patients listed for kidney transplantation far exceeds the supply of deceased donor kidneys, there is a…2018 American Transplant Congress
Private Insurance is Associated with Reduce Access to HCV Therapy after Liver Transplantation
Effective treatment for hepatitis C virus (HCV) infection has revolutionized post liver transplant (LTx) care. Administration of direct-acting antiviral agents (DAAs) after HCV+ LTx results…2018 American Transplant Congress
Kidney Allograft Vascular Disease Post-Transplant (KTX): Risk Factors and Implications
1Medicine, Mayo Clinic, Rochester, MN; 2Pathology, Mayo Clinic, Rochester, MN.
Background: Over time grafts develop arteriosclerosis (ART)and arteriolar hyalinosis (AH). Previous studies associated AH with calcineurin inhibitors (CNI), diabetes (DM), kidney age and hypertension. Other…2018 American Transplant Congress
Genomic Diversity of Epstein Barr Virus in Post-Transplant Lymphoproliferative Disorder
Purpose: In transplant recipients, Epstein-Barr Virus (EBV) is associated with the development of B cell lymphomas in post-transplant lymphoproliferative disorder (PTLD). We utilized next-generation sequencing…2018 American Transplant Congress
Identification of T Cells as Target of Intervention to Decrease Anti-LG3 Autoantibody Levels Prior to Transplantation
Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Autoantibodies against perlecan/LG3 fragment (anti-LG3) have been associated with accelerated allograft rejection and long-term renal allograft dysfunction. Intriguingly, anti-LG3 are present prior to transplantation in…2018 American Transplant Congress
A Novel Nomogram-Based Approach for Defining the Effect of Transplantation on Cancer Recurrence Risk
1U of Cincinnati, Cincinnati; 2Cleveland Clinic, Cleveland.
The effect of transplantation on renal cell cancer (RCC) recurrence risk has not yet been precisely defined. Validated nomograms for predicting RCC recurrence risk (viz,…2018 American Transplant Congress
An Individualized Strategy Using Virus and Immune-Based Markers to Prevent Cytomegalovirus Disease after Face Transplantation
Introduction: There is limited data on CMV prevention after face transplantation. We report an individualized approach using prophylaxis followed by surveillance and preemptive therapy guided…2018 American Transplant Congress
Rapamycin Impairs Human Endothelial Cell Alloimmunogenicity Independent of PD-1/PD-1 Ligand Inhibitory Signaling
Department of Surgery, Duke University Medical Center, Durham, NC.
Rapamycin prevents costimulation blockade (CoB)-resistant rejection in mice and primates, and early human data suggests a similar salutary effect. We have hypothesized that one mechanism…
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