Am J Transplant, Volume 18, Suppl 3 Archives - Page 11 of 211 - ATC Abstracts

2018 American Transplant Congress
HLA-DR4 Matching and Hepatocellular Carcinoma Recurrence after Liver Transplantation
M. Xu, S. Garcia-Aroz, N. Vachharajani, Y. Lin, W. Chapman.
Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St. Louis, MO.
PURPOSE: The phenomenon of graft versus host disease after orthotopic liver transplantation (OLT) is estimated at approximately 1-2%, suggesting that under some circumstances, the graft…
2018 American Transplant Congress
TORC1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
B. Al Dulaijan, S. Eskandari, J. Karnyski, J. Assaker, S. Cai, A. Mansouri, M. Mohamed, J. Azzi.
Transplantation Research Center, BWH, Harvard Medical School, Boston, MA.
The safety and efficacy of adoptive transfer of regulatory T cells (Tregs) are being extensively investigated in ongoing clinical trials. However, these trials have been…
2018 American Transplant Congress
Improving the Organ Donation Referral Process through Telemedicine
M. Groveman,¹ M. Perry,² I. Berman,² N. Benavides,¹ A. Friedman.¹
¹LiveOnNY, NY; ²Northwell Health, New Hyde Park.
Development of a Tele-ICU serving multiple institutions within our donor service area stimulated a collaborative performance improvement project. To improve the referral and timeliness rates…
2018 American Transplant Congress
Role of B Cell Intrinsic NLRP3 in the Development of Chronic Rejection
J. Nie,¹ B. Ramaswami,² X. Guo,³ R. Hoffman,² G. Chalasani.³
¹Thoracic Surgery, Huazhong University of Science and Technology, Wuhan, Hubei, China; ²Surgery, Starzl Transplantation Institute, Pittsburgh, PA; ³Medicine, University of Pittsburgh, Pittsburgh, PA.
Endogenous DAMPs elicited during transplantation are recognized via TLR-MyD88 and NLRP3-inflammosome pathways that are expressed in APCs including B cells. Here, we asked whether B…
2018 American Transplant Congress
Intragraft MicroRNAs Foretell Fibrosis in Kidney Transplant Recipients
H. Yang,¹ L. Amrouche,² K. Akat,³ C. Li,¹ Z. Khan,¹ C. Tinel,² T. Tuschl,³ D. Anglicheau,² T. Muthukumar.¹
¹Weill Cornell Medicine, New York; ²Hôpital Necker, Paris, France; ³Rockefeller University, New York.
BackgroundIdentifying biomarkers that anticipate tubulointerstitial fibrosis (IFTA) of the kidney allograft will be a transformative advance.Aim/HypothesisIntragraft microRNA profile of 3-month surveillance biopsies reported as normal…
2018 American Transplant Congress
Clinical Significance and Therapeutic Potential of Orosomucoid 1 for Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients
H. Higuchi,^1,2 K. Hotta,¹ D. Iwami,¹ J-.J. Jiang,² D. Kamimura,² Y. Arima,² T. Atsumi,² Y. Takada,^1,2 H. Harada,³ M. Murakami,² N. Shinohara.¹
¹Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; ²Division of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; ³Department of Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Hokkaido, Japan.
［Background］We reported a molecular mechanism to develop chronic inflammation (CI), called the inflammation amplifier (IA). IA is activated by concomitant activation of NFkB and STAT3…
2018 American Transplant Congress
Long-Term HIF-1α Stabilization is Associated with Fibrosis in Rat Lung Allografts
K. Freischlag,¹ B. Ezekian,¹ P. Schroder,¹ J. Everitt,¹ J. Yoon,¹ M. Swiderska-Syn,³ W. Parker,¹ A. Diehl,¹ J. Kwun,¹ S. Knechtle.¹
¹Duke Transplant Center, Duke University, Durham, NC; ²Medical University of South Carolina, Charleston, SC.
Introduction: HIF-1α is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) and functions as a master transcriptional regulator of cellular and developmental…
2018 American Transplant Congress
Association of CYP3A5*3*6*7 Metabolic Composites to Tacrolimus Pharmacokinetics in African American and Caucasian Renal Transplant Recipients
K. Tornatore,^1,5 D. Brazeau,² C. Meaney,¹ K. Attwood,^3,4 G. Wilding,⁴ S. Chang,⁵ R. Venuto.⁵
¹Pharmacy, School of Pharmacy, University at Buffalo(UB), Buffalo; ²Pharmaceutical Sciences, College of Pharmacy; University of New England, Portland; ³Biostatistics, Roswell Park Cancer Institute, Buffalo; ⁴Biostatistics, UB School of Public Health, Buffalo; ⁵Nephrology, UB School of Medicine, Buffalo.
Background: Interpatient variability in tacrolimus pharmacokinetics(PK) is due primarily to metabolism by cytochrome P-450 3A5(CYP3A5) isoenzymes. African Americans(AA) require higher tacrolimus doses to achieve comparable…
2018 American Transplant Congress
In Vivo Allograft Exposure to Mitochondrial DAMPs Prior to Organ Procurement Increases Graft Rejection in Mice
L. Lin, J. Wang, L. Cendales, A. Kirk, T. Brennan.
Surgery, Duke University, Durham, NC.
Mitochondria released in the setting of tissue injury are a source of damage associated molecular patterns (DAMPs) that initiate innate immune responses. We hypothesized that…
2018 American Transplant Congress
CXCR4 Inhibition Improves Donor Leukocyte Depletion during Ex Vivo Lung Perfusion
R. Davis, Q. Gao, J. Yerxa, M. Daneshmand, J. Haney, J. Klapper, M. Hartwig, A. Barbas.
Surgery, Duke University, Durham, NC.
Background: Ex vivo lung perfusion (EVLP) has emerged as a modern preservation technique, developed to evaluate candidate donor lungs in a normothermic and metabolically active…