Am J Transplant, Volume 18, Suppl 3 Archives - Page 107 of 211 - ATC Abstracts

2018 American Transplant Congress
Th17 and NK Responses Are Differentially Induced in Renal Allografts According to Recipient Murine Cytomegalovirus Dose and Strain
M. Shimamura,¹ M. Li,² S. Boddeda,¹ B. Chen,² Q. Zeng,¹ T. Schoeb,² V. Velazquez.¹
¹Center for Vaccines and Immunity and Dept. of Pediatric Infectious Diseases, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH; ²Depts. of Pediatric Infectious Diseases, Pathology, and Genetics, University of Alabama at Birmingham, Birmingham, AL.
Purpose: To study the impact of cytomegalovirus (CMV) recipient positive (R+) serostatus upon renal allograft injury, murine CMV (MCMV) D+/R+ kidney transplants using recipients infected…
2018 American Transplant Congress
The Benefit of Higher KDPI Renal Transplantation over Waiting for a Better Offer
E. Grodstein,¹ J. Yang,² V. Nair,¹ E. Molmenti,¹ L. Teperman.¹
¹Transplant Institute, Northwell Health, Manhasset, NY; ²Department of Epidemiology, Northwell Health, Manhasset, NY.
Background: The kidney donor profile index (KDPI) helps discern kidney function. While recipients must consent for KDPI >85% kidneys, clinicians often decide whether to accept…
2018 American Transplant Congress
Prevalence of Frailty among Kidney Transplant Recipients in the United States
A. Thomas,¹ A. Shaffer,¹ H. Ying,¹ S. Norman,² D. Segev,¹ M. McAdams-DeMarco.¹
¹JHU, Baltimore; ²University of Michigan, Ann Arbor.
Frailty, a measure of physiologic reserve, increases the risk of delayed graft function, longer length of stay, early hospital readmission, immunosuppression intolerance, and mortality among…
2018 American Transplant Congress
Delayed Graft Function in Simultaneous Liver Kidney Transplantation
S. Weeks,¹ X. Luo,¹ S. Ottmann,¹ A. Gurakar,² F. Naqvi,² B. Philosophe,¹ A. Cameron,¹ N. Desai,¹ D. Segev,¹ J. Garonzik Wang.¹
¹Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD; ²Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD.
Purpose: Increased rates of delayed graft function (DGF) after simultaneous liver kidney (SLK) transplantation have been described, as well as inferior graft survival in patients…
2018 American Transplant Congress
Approaches to Prevention of Antibody Rebound after HLA Sensitization in a Mouse Model
I. Kim, G. Wu, N-.N. Chai, A. Klein, S. Jordan.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Purpose: Control of donor specific antibodies (DSA) is critical for prevention of antibody mediated rejection (ABMR). Removal of DSAs with PLEX often results in significant…
2018 American Transplant Congress
Prevention and Reversal of Diabetes through Restoration of B and T Cell Regulation and Immune Homeostasis
K. Brayman,¹ P. Chhabra,¹ C. Wilson,² A. Marshall,² D. Moore.²
¹Surgery, University of Virginia, Charlottesville, VA; ²Pediatric Endocrinology, Vanderbilt University, Nashville, TN.
Goal: To determine the mechanisms by which IgM restores immune homeostasis in new-onset diabetic NOD mice.Methods: 1) 5wks old non-obese diabetic (NOD) mice received mouse…
2018 American Transplant Congress
Circulating Exosomes with Lung Self-Antigens, Kα1Tubulin and Collagen V, and Immune Regulatory Proteins in Lung Transplant Recipient with Primary Graft Dysfunction
M. Sharma, S. Biswas Roy, R. Walia, A. Omar, R. Bremner, M. Smith, T. Mohanakumar.
Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix.
Background: Circulating exosomes isolated from lung transplant recipients (LTxRs) with acute or chronic rejection contains lung self-antigens (SAgs), K alpha 1 tubulin (Kα1T) and collagen…
2018 American Transplant Congress
Treatment of Active Chronic Antibody-Mediated Rejection with Rituximab, IVIG and Plasma Exchange
G. Piñeiro,¹ J. Rovira,² E. De Sousa-Amorim,¹ J. Villarreal,¹ M. Sole,³ I. Revuelta,¹ M. Lozano,⁴ E. Palou,⁴ F. Oppenheimer,¹ J. Campistol,¹ F. Diekmann.^1,2
¹Nephrology and Renal Transplantation, Hospital Clinic de Barcelona, Barcelona, Spain; ²Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain; ³Pathology, Hospital Clinic de Barcelona, Barcelona, Spain; ⁴Apheresis Unit, Hemotherapy and Hemostasis, Hospital Clinic de Barcelona, Barcelona, Spain; ⁵Immunology, Hospital Clinic de Barcelona, Barcelona, Spain.
Chronic antibody-mediated rejection (cABMR) and transplant glomerulopathy (TG) are main features associated with long-term graft loss. Despite its clinical significance, the available evidence on treatment…
2018 American Transplant Congress
Association of Health Literacy with Adverse Outcomes among Kidney Transplant Candidates and Recipients
F. Warsame, C. Haugen, J. Garonzik-Wang, N. Desai, D. Crews, T. Purnell, M. McAdams-DeMarco, D. Segev.
Johns Hopkins University, Baltimore, MD.
Limited health literacy (LHL) is known to adversely affect health outcomes in patients managing chronic illness. We aimed to examine the association between LHL, listing,…
2018 American Transplant Congress
Outcomes in Liver and Combined Liver-Kidney Retransplantation
D. Sonnier, D. Bruce, H. Bohorquez, E. Bugeaud, I. Carmody, A. Cohen, A. Mathur, J. Seal, G. Loss.
Department of Surgery/Transplantat, Ochsner Clinic, New Orleans, LA.
Many centers consider liver retransplantation controversial due to poor outcomes and high resource requirement. In the setting of renal failure and high MELD, many are…