Am J Transplant, Volume 18, Suppl 3 Archives - Page 106 of 211 - ATC Abstracts

2018 American Transplant Congress
Expression of the Senescence Marker P16/INK4A in Kidney Implantation Biopsies is Uniquely Associated with Poor Late Graft Function
K. Famulski, P. Halloran.
University of Alberta, Edmonton, Canada.
With the aging donor population, accurate assessment of tissue quality of deceased donor kidneys is required to determine the intermediate and long term graft performance,…
2018 American Transplant Congress
The Impact of Aorto-Iliac Calcifications on Patient and Graft Survival in Renal Transplant Recipients Using the TASC II Classification
A. Rijkse,¹ M. van der Zijden,² J. Roodnat,² S. Ten Raa,³ D. Bijdevaate,⁴ K. Muller,¹ J. IJzermans,¹ H. Kimenai,¹ R. Minnee.¹
¹Department of Transplantation Surgery, Erasmus University Medical Center, Rotterdam, Netherlands; ²Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands; ³Department of Vascular Surgery, Erasmus University Medical Center, Rotterdam, Netherlands; ⁴Department of Radiology, Erasmus University Medical Center, Rotterdam, Netherlands.
Introduction: Kidney transplantation (KTx) is the therapy of choice in patients with end-stage renal disease. Aorto-iliac calcifications (AIC) are a relative contra-indication for KTx, even…
2018 American Transplant Congress
Living Donor Liver Transplantation for Alcoholic Liver Disease: Data from the A2ALL Study
H. Braun, J. Dodge, J. Grab, S. Syed, G. Roll, C. Freise, J. Roberts, N. Ascher.
Surgery, University of California, San Francisco, San Francisco, CA.
The literature on living donor liver transplantation (LDLT) for alcoholic liver disease (ALD) is primarily from single Asian centers. We investigated LDLT outcomes for ALD…
2018 American Transplant Congress
Antiviral Therapy for Donor-Derived Hepatitis C Virus Infection after Solid Organ Transplantation
A. Kwong,¹ A. Wall,² M. Melcher,² U. Wang,³ A. Ahmed,¹ K. Khush,³ A. Subramanian,³ J. Tan,³ P. Kwo.¹
¹Gastroenterology and Hepatology, Stanford University, Palo Alto, CA; ²Surgery, Stanford University, Palo Alto, CA; ³Stanford University, Palo Alto, CA.
Background: In the context of organ shortage, the opioid epidemic, and the advent of effective direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV), more…
2018 American Transplant Congress
Long-Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients
J. Leventhal,¹ J. Galvin,¹ J. Mathew,¹ L. Gallon,¹ D. Stare,¹ K. Kurtenbach,¹ K. Ravindra,³ M. Horwitz,³ J. Miller,¹ M. Abecassis,¹ S. Ildstad.²
¹Surgery, Northwestern U, Chicago; ²U of Louisville, Louisville; ³Duke U, Durham.
37 pts have been transplanted in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts (KTx). The protocol is based…
2018 American Transplant Congress
Superior Renal Function with CNI-Free Everolimus over Standard CNI-Based Regimen: 18 Months Data from the Randomized, Multi-Center MANDELA Trial in De Novo Heart Transplant Recipients
M. J. Barten,¹ S. W. Hirt,¹ J. Garbade,¹ C. Bara,¹ A. Doesch,¹ C. Knosalla,¹ C. Grinninger,¹ J. Stypmann,¹ C. Sieder,² M. Junge,² U. Schulz.¹
¹Mandela Study Group, Germany; ²Novartis, Pharma, Germany.
Purpose: The MANDELA study (NCT00862979) was designed to assess the benefit on renal function of either CNI-free or CNI-minimized EVR-based regimen after early conversion of…
2018 American Transplant Congress
Elucidating Novel Signatures of Allograft Rejection through Cytometry by Time of Flight (CyTOF) in Kidney Transplant Recipients
S. Eskandari,¹ B. Al Dulaijan,¹ J. Assaker,¹ L. Riella,¹ A. Kurdi,² J. Azzi.¹
¹Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
Mass cytometry by time-of-flight (CyTOF) permits the simultaneous assessment of over 40 functional and phenotypic parameters at the single-cell level. This novel tool holds tremendous…
2018 American Transplant Congress
The Use of LiMAx for Evaluating Donor Livers on Normothermic Machine Perfusion
J. Schurink,¹ J. de Haan,² M. Verstegen,¹ H. Metselaar,³ J. Ijzermans,¹ J. de Jonge.¹
¹Surgery, Erasmus MC, Rotterdam, Zuid Holland, Netherlands; ²Intensive Care Medicine, Erasmus MC, Rotterdam, Zuid Holland, Netherlands; ³Gastroenterology, Erasmus MC, Rotterdam, Zuid Holland, Netherlands.
Due to the organ shortage, inferior quality livers from donors after circulatory arrest (DCD) are offered to relieve mortality on the waiting list. The threshold…
2018 American Transplant Congress
Brain Death Conditions Intensify Inflammation and Impair Metabolic Gene Expression
L. Zitur, P. Chlebeck, S. Odorico, T. Zens, J. Danobeitia, M. Eerhart, J. Reyes, A. D'Alessandro, K. Brunner, S. Capuano, L. Fernandez.
University of Wisconsin, Madison.
Rationale: Inflammation observed in Brain Death (BD) donors is linked to reduced graft function and survival compared to living donors (LD). Detailed analyses of non-human…
2018 American Transplant Congress
Recipient Conditioning Results in IL-33 Support of Potent Th1 Alloimmune Responses after CD4⁺ T Cells Upregulate ST2 during Lymphopenia Induced Proliferation
G. Dwyer,¹ L. Mathews,¹ A. Lucas,¹ B. Blazar,² H. Turnquist.¹
¹Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; ²Department of Pediatrics, University of Minnesota, Minneapolis, MN.
Purpose: IL-33 is typically associated with support of Th2 and Treg responses. Yet, recipient conditioning before allogeneic hematopoietic cell transplantation (alloHCT) releases IL-33 to promote…