Am J Transplant, Volume 18, Suppl 3 Archives - Page 106 of 211 - ATC Abstracts

2018 American Transplant Congress
Building a Third-Party VST Bank from Scratch- The Cincinnati Experience
A. S. Nelson,¹ D. Heyenbruch,² X. Zhu,³ S. M. Davies,¹ C. Lutzko,³ C. Bollard,⁴ P. Hanley,⁴ T. Leemhuis,² L. Danziger-Isakov,⁵ M. S. Grimley.¹
¹Bone Marrow Transplant & Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ²Hoxworth Blood Center, Univeristy of Cincinnati, Cincinnati, OH; ³Experimental Hematology & Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ⁴Proram for Cell Enhancement and Technologies for Immunotherapy, Children's National Health System, Washington, DC; ⁵Depatment of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
BackgroundViral infections remain a challenge to treat and significantly contribute to morbidity and mortality. Virus specific T cells (VSTs) have shown clinical efficacy, with minimal…
2018 American Transplant Congress
Precision (re)Phenotyping of Histologically Stable Kidney Transplants
D. Rychkov,¹ T. Sigdel,² M. Sirota,¹ M. Sarwal.²
¹Institute for Computational Health Sciences, UCSF, San Francisco, CA; ²Department of Surgery, UCSF, San Francisco, CA.
Background: Acute Rejection (AR) is the main cause of the renal failure within one year after transplantation (tx). Its earlier diagnosis is crucial for a…
2018 American Transplant Congress
Carfilzomib and Belatacept Reduces DSA and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation
B. Ezekian, J. Kwun, P. Schroder, M. Manook, J. Yoon, M. Mulvihill, K. Freischlag, J. Cochran, K. Kroning, J. Yi, S. Knechtle.
Duke Transplant Center, Duke University Medical Center, Durham, NC.
Purpose:Sensitized kidney transplant (KT) recipients have poor access to transplantation and inferior outcomes when transplanted. Conventional methods of desensitization remove donor specific antibody (DSA) temporarily,…
2018 American Transplant Congress
Identification of Exosomal Isletokines Released by Pancreatic Islets in Response to Inflammatory Stress
P. Saravanan,¹ G. Yoshimatsu,¹ R. Bhattacharjee,¹ C. Chang,¹ C. Darden,¹ B. Naziruddin,² M. Lawrence.¹
¹Islet Cell Lab, Baylor Scott & White Research Institute, Dallas, TX; ²Transplantation, Baylor Simmons Transplant Institute, Dallas, TX.
Purpose: To identify isletokines released by exosomes from human islets that have been exposed to hypoxic or inflammatory conditions and define stress signaling pathways that…
2018 American Transplant Congress
Everolimus with Reduced-Dose Calcineurin Inhibitor versus Mycophenolate with Standard-Dose Calcineurin Inhibitor in De Novo Kidney Transplant Recipients: Renal Function Results from the TRANSFORM Study
F. Oppenheimer,¹ C. Legendre,¹ J. Cruzado,¹ G. Russ,¹ O. Viklicky,¹ R. Oberbauer,¹ V. Garcia,¹ O. Witzke,¹ D. Kuypers,¹ R. Danguilan,¹ P. Bernhardt,² C. Sommerer.¹
¹TRANSFORM Study Group, Barcelona, Spain; ²Novartis Pharma AG, Basel, Switzerland.
Purpose: TRANSFORM (NCT01950819) is the largest study conducted in de novo kidney transplant recipients (KTxRs) to evaluate the benefit of everolimus with reduced-dose calcineurin inhibitor…
2018 American Transplant Congress
The Altruistic Living Kidney Donor Phenotype – From Inquiry to Donation
V. Kumar, P. MacLennan, M. Bonventre, M. Hanaway, R. Reed, J. Locke.
University of Alabama at Birmingham, Birmingham.
BackgroundWe distinguish an altruistic donor from the traditional living donor when a living person's offer to donate an organ is to “anyone” and not attached…
2018 American Transplant Congress
Safety of Antithymocyte Globulin Use in Donation after Circulatory Death (DCD) Liver Transplantation
D. Felix,¹ B. Geiger,¹ J. Descourouez,¹ M. Jorgenson,¹ B. Hanlon,² G. Leverson,² D. Foley.²
¹Department of Pharmacy, UW Health, Madison, WI; ²Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Purpose: Rabbit antithymocyte globulin (rATG) is commonly used for induction immunosuppression and treatment of rejection in solid organ transplantation. Previous work has shown that rATG…
2018 American Transplant Congress
Prospective Trial Using Pulmonary Rehabilitation to Treat Frailty
C. Kennedy,¹ P. Novotny,² E. Stevens,¹ J. Kirsch,³ J. Garrett,¹ N. LeBrasseur,⁴ R. Benzo.¹
¹Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN; ²Health Sciences Research, Mayo Clinic, Rochester, MN; ³Clinical and Health Psychology, University of FL, Gainesville, FL; ⁴Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN.
Background: Frailty is a novel risk factor to potential lung transplant candidates and recipients associated with excess morbidity and mortality. Limited data is available on…
2018 American Transplant Congress
Th17 and NK Responses Are Differentially Induced in Renal Allografts According to Recipient Murine Cytomegalovirus Dose and Strain
M. Shimamura,¹ M. Li,² S. Boddeda,¹ B. Chen,² Q. Zeng,¹ T. Schoeb,² V. Velazquez.¹
¹Center for Vaccines and Immunity and Dept. of Pediatric Infectious Diseases, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH; ²Depts. of Pediatric Infectious Diseases, Pathology, and Genetics, University of Alabama at Birmingham, Birmingham, AL.
Purpose: To study the impact of cytomegalovirus (CMV) recipient positive (R+) serostatus upon renal allograft injury, murine CMV (MCMV) D+/R+ kidney transplants using recipients infected…
2018 American Transplant Congress
The Benefit of Higher KDPI Renal Transplantation over Waiting for a Better Offer
E. Grodstein,¹ J. Yang,² V. Nair,¹ E. Molmenti,¹ L. Teperman.¹
¹Transplant Institute, Northwell Health, Manhasset, NY; ²Department of Epidemiology, Northwell Health, Manhasset, NY.
Background: The kidney donor profile index (KDPI) helps discern kidney function. While recipients must consent for KDPI >85% kidneys, clinicians often decide whether to accept…