Am J Transplant, Volume 18, Suppl 3 Archives - Page 105 of 211 - ATC Abstracts

2018 American Transplant Congress
Donor Reactive Eomesdermin^hiCD8⁺ T Cells Are Significantly Upregulated Early after Transplant in Kidney Transplant Patients without Rejection
A. Perez-Gutierrez,^1,2 D. Metes,¹ S. Hariharan,¹ A. Thomson,¹ M. Ezzelarab.¹
¹Surgery, Thomas Starzl Transplantation Institute, Pittsburgh, PA; ²Surgery, Transplantation Institute, University of Chicago, Chicago, IL.
IntroductionMemory T cell responses play a critical role in the outcome of allo-transplantation. While the role of the T-box transcription factor Eomesodermin (Eomes) in the…
2018 American Transplant Congress
Examples of the Observer Effect in Transplantation- Unintended Consequences of Regulation and Selected Outcome Metrics
A. Rana, M. Kueht, N. Galvan, R. Cotton, C. O'Mahony, J. Goss.
Abdominal Transplantation, Baylor College of Medicine, Houston, TX.
Introduction: The influence of an observer on the phenomena being observed is designated as the observer effect. It is our aim to demonstrate that an…
2018 American Transplant Congress
Development of Denovo DSA after One Year Post Kidney Transplant and Clinical Outcomes in Patient on Steroid Free Immunosupression
A. Sharfuddin, M. Yaqub, D. Mishler, W. Goggins, T. Taber, O. Adebiyi.
Division of Renal Disease and Hypertension, Indiana University Health Transplant Program, Indianapolis, IN.
Background: Development of Denovo donor specific antibodies (DnDSA) has been associated with poor allograft outcomes in few studies. However, there is scarcity of data evaluating…
2018 American Transplant Congress
Unique Gene Expression Signatures in Urine Distinguish BK Virus Nephropathy from Acute Rejection in Kidney Transplant Patients with Graft Dysfunction
K. Keslar,¹ P. Gotwald,¹ W. Xu,² A. Zmijewska,³ J. Chen,³ K. Newell,⁴ P. Heeger,⁵ J. Bromberg,⁶ R. Mannon,³ R. Fairchild,¹ The CTOT Consortium.
¹Cleveland Clinic, Cleveland, OH; ²Nanostring Technologies, Seattle, WA; ³University of Alabama at Birmingham, Birmingham, AL; ⁴Emory University, Atlanta, GA; ⁵Icahn School of Medicine at Mt. Sinai, New York, NY; ⁶University of Maryland, Baltimore, MD.
Acute cellular rejection and BK virus nephropathy both cause deteriorating graft function that can lead to graft loss. Distinguishing the two conditions rapidly and accurately…
2018 American Transplant Congress
Are Deceased Donor Characteristics Associated with Liver Graft Failure among Low MELD Patients Receiving a Liver Transplant Changing
K. Atiemo,¹ A. Skaro,² R. Craig-Schapiro,¹ S. Montag,¹ L. VanWagner,¹ M. Abecassis,¹ J. Levitsky,¹ L. Zhao,¹ D. Ladner.¹
¹Nothwestern, Chicago; ²Western University, London, Canada.
Intr Low MELD patients have less access to liver transplantation (LT) and increasingly receive 'marginal' organs with risk of graft failure (GF). Despite increased utilization…
2018 American Transplant Congress
Ten Year Follow-Up of Islet Recipients on Anti-LFA1 Therapy: Over-Immunosuppression Leads to Operational Tolerance?
J. Gardner,¹ A. Posselt,¹ S. Wisel,¹ U. Mashirani,² G. Szot,¹ V. Nguyen,¹ K. Johnson,¹ J. McElroy,¹ Q. Tang,¹ P. Stock.¹
¹Surgery, University of California, San Francisco, San Francisco, CA; ²Endocrinology, University of California, San Francisco, San Francisco, CA.
Introduction: Ten-year outcomes from a cohort of five pre-uremic islet transplant (txp) recipients treated with anti-leukocyte functional antigen-1 (LFA-1) antibody Efalizumab (EFA) revealed two patients…
2018 American Transplant Congress
HO-1 Regulates SIRT1– Autophagy Pathway in Liver Transplantation: From Mouse-to-Human
K. Nakamura,¹ S. Kageyama,¹ S. Yue,¹ A. Aziz,¹ T. Ito,¹ D. Oncel,¹ B. Ke,¹ R. Sosa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Division of Liver Transplantation, UCLA, Los Angeles, CA; ²Pathology and Laboratory Medicine, UCLA, Los Angeles, CA.
Liver ischemia-reperfusion injury (IRI) represents a major risk factor for early graft dysfunction and a key obstacle to expanding the donor pool in orthotopic liver…
2018 American Transplant Congress
Temporal Trends, Predictive Factors, and Regional Differences in Discard of Increased-Risk Kidneys
J. Lipinska, D. Clark, J. Whiting.
Surgery, Maine Medical Center, Portland, ME.
Purpose: Public Health Service (PHS) criteria designate certain deceased donors (DD) as entailing increased risk (IR) for disease transmission, and these constitute an expanding proportion…
2018 American Transplant Congress
Few Gender Differences in Attitudes and Experiences after Live Kidney Donation, with Minor Changes over Time
J. Wadström,^1,2 B. von Zur-Mühlen,³ S. Yamamoto.³
¹Department of Transplantation Surgery, Karolinska University Hospital, Huddinge, Sweden; ²Department of Surgery/Transplantation, Hamad Medical Corporation, Doha, Qatar; ³Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden.
Background: We sought to study gender differences and differences over time with respect to demographics, relation to recipient, donor motives, and experiences of live kidney…
2018 American Transplant Congress
Split/Reduced Liver Grafts in Adult Liver Transplantation, No Longer a Risk for Graft Loss
K. Sasaki, D. Firl, J. McVey, G. Iuppa, M. Fujiki, T. Diago Uso, F. Aucejo, B. Eghtesad, C. Quintini, C. Miller, K. Hashimoto.
General Surgery, Cleveland Clinic, Cleveland, OH.
Objective:Split/reduced graft liver transplantation(SRLT), while widely accepted in pediatrics, remains underutilized in adults. SRLT is considered a negative factor for graft quality(HR;1.52) in liver donor…