Am J Transplant, Volume 18, Suppl 3 Archives - Page 105 of 211 - ATC Abstracts

2018 American Transplant Congress
Donor Derived Renal Cell Carcinoma (RCC) Transmission Events 2008-2016: A Report of the OPTN Disease Transmission Advisory Committee (DTAC)
M. Pavlakis, M. Michaels, S. Tlusty, N. Turgeon, G. Vece, C. Wolfe, R. Wood, M. Nalesnik.
OPTN/UNOS, RCC Work Group.
Background: RCC is the most common renal tumor reported to the OPTN and reviewed by DTAC for assessment of potential donor transmission. Organs with concern…
2018 American Transplant Congress
Assessment and Validation of Potential Predictors of Non-Adherence in Contemporary Kidney Transplant Recipients
T. Harrison, C. Perez, N. Patel, H. Meadows, J. Fleming, N. Pilch, B. O'Brien, H. Corbo, J. Hardcopf, P. Baliga, D. DuBay, D. Taber.
Medical University of South Carolina, Charleston, SC.
The aim of this study is to assess the associations between traditional proxies of medication non-adherence and graft outcomes in contemporary kidney transplant recipients (KTRs).Methods:…
2018 American Transplant Congress
Impact of Elevated PSA, and Prostate Cancer in ESRD on Time to Transplant, and Survival
N. Sarabu,¹ N. Schiltz,² D. Hricik.¹
¹University Hospitals of Cleveland, Cleveland, OH; ²Case Western Reserve University, Cleveland, OH.
Introduction: Despite concerns for over-diagnosis and over-treatment from prostate cancer screeening, transplant centers perform it. We studied effect of Elevated PSA, and Prostate cancer on…
2018 American Transplant Congress
Combination Proteasome Inhibition and Anti-BAFF Therapy Permits Highly Sensitized Rhesus Kidney Transplantation
B. Ezekian, J. Kwun, M. Manook, P. Schroder, J. Yoon, M. Mulvihill, K. Freischlag, J. Park, J. Cochran, K. Kroning, J. Yi, S. Knechtle.
Duke Transplant Center, Duke University Medical Center, Durham, NC.
Purpose:HLA-sensitization is a significant immunologic barrier to successful kidney transplantation (KT). We have shown that proteasome inhibition (PI) in insolation reduces plasma cells (PCs), but…
2018 American Transplant Congress
CTLA4-Ig and Bortezomib Successfully Reverses Established DSA Responses in Allograft-Sensitized Recipients
D. Jain,¹ J. Young,¹ D. Yin,¹ R. Pelletier,² A. Chong.¹
¹Department or Surgery, University of Chicago, Chicago, IL; ²Department of Surgery, Ohio State University, Columbus, OH.
Background: Sensitized recipients have lower rates of transplantation and poorer outcomes. We and others have reported that the delayed administration of CTLA4-Ig can disrupt fully-established…
2018 American Transplant Congress
Prolonged Cold Ischemia Storage of Renal Allografts Shifts DSA Specificity and Enchances Glomerular Injury
V. Gorbacheva, R. Fan, W. Baldwin, A. Valujskikh.
Immunology, Cleveland Clinic, Cleveland, OH.
Prolonged cold ischemia storage (CIS) of donor organs is a major risk factor for acute and chronic graft injury. The goal of this study was…
2018 American Transplant Congress
Antibody-Verified Eplet Mismatches as Determinants of Premature Kidney Transplant Loss
R. Sapir-Pichhadze,¹ X. Zhang,¹ A. Ferradji,¹ A. Madbouly,² S. Fingerson,² K. Tinckam,⁵ H. Gebel,³ H. Cardinal,⁴ B. Foster.¹
¹McGill University, Montreal, Canada; ²National Marrow Donor Program, Minneapolis; ³Emory University Hospital, Atlanta; ⁴CHUM, Montreal, Canada; ⁵University Health Network, Toronto, Canada.
Introduction: HLA matching at the epitope level offers new opportunities to identify compatible donors for transplant candidates. HLAMatchmaker deduces B-cell epitope ('eplets' in HLAMatchmaker) mismatches…
2018 American Transplant Congress
Relationship between Living Kidney Donor Follow-Up GFR and Recipient Graft Loss
C. Holscher,¹ T. Ishaque,¹ C. Haugen,¹ S. DiBrito,¹ K. Jackson,¹ A. Muzaale,¹ A. Massie,^1,2 M. Henderson,¹ J. Garonzik Wang,¹ D. Segev.^1,2,3
¹Johns Hopkins School of Medicine, Baltimore; ²Johns Hopkins School of Public Health, Baltimore; ³Scientific Registry of Transplant Recipients, Minneapolis.
In living kidney transplantation, it is reasonable to believe a donated kidney's function would be associated with the function of the donor's remaining kidney. Indeed,…
2018 American Transplant Congress
The Impact of Donor Specific Alloantibodies on Long-Term Outcomes of Liver Re-Transplantation
Q. Xu,¹ A. Skaro,² V. McAlister.²
¹Department of Pathology and Lab Medicine, University of Western Ontario, London, ON, Canada; ²Department of Surgery, University of Western Ontario, London, ON, Canada.
Despite reports that associate donor specific antibody (DSA) with rejection after liver transplantation, grafts are still allocated according to blood group (ABO) but not human…
2018 American Transplant Congress
Waiting for the Optimal Donor for MCS Patients Awaiting Heart Transplant
J. Kobashigawa, J. Patel, E. Kransdorf, R. Levine, S. Dimbil, E. Passano, L. Czer, J. Moriguchi, F. Arabia.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Patients (pts) bridged with mechanical circulatory support (MCS) may require more optimal donors for best outcome compared to non-bridged transplant recipients. MCS pts have…