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American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Alloreactive B Cells Acquire Cell-Intrinsic Hyporesponsiveness in Tolerant Recipients

    S. Khiew,1 D. Jain,1 J. Young,1 J. Chen,1 J. Yang,1 Q. Wang,1 D. Yin,1 R. Sciammas,2 A. Chong.1

    1Department of Surgery, The University of Chicago, Chicago, IL; 2Comparative Medicine, University of California, Davis, CA.

    Donor-specific transplantation tolerance has long been an aspiration of clinical transplantation. Recently, we have reported that multiple mechanisms are required to reinforce profound hyporesponsiveness of…
  • 2018 American Transplant Congress

    Molecular Assessment of Pre-Implantation Donor Biopsies: Effects of Prolonged Cold Ischemia Time and Development of Delayed Graft Function

    E. Akalin,1 Y. Bao,1 V. Bontha,2 M. e Silva,3 M. Ajaimy,1 P. [Oacute] Broin,3 V. Mas.2

    1Montefiore Medical Center, Bronx; 2University of Virginia, Charlottesville; 3National University of Ireland Galway, Galway, Ireland.

    Background: Deceased-donor (DD) kidneys are at higher risk for ischemia/reperfusion injury leading to increased inflammatory mediators and innate immune response. We aimed to investigate the…
  • 2018 American Transplant Congress

    Impact of the Kidney Allocation System on Young Pediatric Recipients

    W. Parker,1 L. Ross,1 J. Thistlethwaite,1 A. Gallo.2

    1University of Chicago, Chicago, IL; 2Stanford University, Palo Alto, CA.

    Purpose: The Kidney Allocation System (KAS) altered the priority of pediatric candidates for deceased donor kidney transplantation. Before long-term graft outcomes can be assessed, Delayed…
  • 2018 American Transplant Congress

    Proton-Pump Inhibitor Utilization is Associated with Higher Rates of Clostridium difficile Infection and Hypomagnesemia after Kidney Transplant

    G. Kipp,2 K. Dancsecs,1 A. Lapping.1

    1School of Pharmacy, Duquesne University, Pittsburgh, PA; 2Abdominal Transplant, Allegheny General Hospital, Pittsburgh, PA.

    The purpose of this project was to identify how many kidney transplant patients were taking a proton pump inhibitor (PPI) after kidney transplant at our…
  • 2018 American Transplant Congress

    Inflammation in Scarred Areas (i-IF/TA): Defining the Response to Standard Treatment of T Cell-Mediated Rejection in Kidney Recipients

    D. Viglietti, O. Aubert, J-.P. Duong Van Huyen, A. Loupy, C. Lefaucheur.

    Paris Translational Research Center for Organ Transplantation, Paris, France.

    The 2017 Banff meeting has focused on the importance of defining the potential role of i-IF/TA as a component of the T cell-mediated rejection (TCMR)…
  • 2018 American Transplant Congress

    A Calculator for Kidney Transplant Waitlist Outcomes under the New Kidney Allocation System

    A. Hart,1,2 N. Salkowski,2 A. Matas,3 B. Kasiske,2 J. Snyder,2 A. Israni.2

    1HCMC, Minneapolis; 2SRTR, Minneapolis; 3Univ of Minnesota, Minneapolis.

    BACKGROUND: Outcomes on the kidney transplant waiting list vary markedly by region and patient characteristics, and the new kidney allocation system (KAS) changed the probability…
  • 2018 American Transplant Congress

    Glycogen Synthase Kinase 3 beta Regulates Liver Inflammation Activation and Resolution by Controlling AMPK Activities

    H. Wang,1,2 M. Ni,1,2 H. Zhou,2 L. Lu,2 R. Busuttil,1 J. Kupiec-Weglinski,1 Y. Zhai.1

    1Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; 2Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

    Background & Aims: Glycogen synthase kinase 3β (Gsk3β) is ubiquitously expressed with distinctive functions in different types of cells. Although its roles in regulating innate…
  • 2018 American Transplant Congress

    Confirmation of the Feasibility of Ex Vivo Creation of a Novel Human Multi-Chimeric Cells Therapy for Tolerance Induction in Vascularized Composite Allotransplantation

    J. Cwykiel, G. Rafidi, M. Siemionow.

    Orthopaedics, University of Illinois at Chicago, Chicago, IL.

    Purpose:Various stem cell-based therapies have been proposed as supportive treatments for patients following solid organ and vascularized composite allotransplantation (VCA) to achieve donor-specific tolerance and…
  • 2018 American Transplant Congress

    Expression of the Senescence Marker P16/INK4A in Kidney Implantation Biopsies is Uniquely Associated with Poor Late Graft Function

    K. Famulski, P. Halloran.

    University of Alberta, Edmonton, Canada.

    With the aging donor population, accurate assessment of tissue quality of deceased donor kidneys is required to determine the intermediate and long term graft performance,…
  • 2018 American Transplant Congress

    The Impact of Aorto-Iliac Calcifications on Patient and Graft Survival in Renal Transplant Recipients Using the TASC II Classification

    A. Rijkse,1 M. van der Zijden,2 J. Roodnat,2 S. Ten Raa,3 D. Bijdevaate,4 K. Muller,1 J. IJzermans,1 H. Kimenai,1 R. Minnee.1

    1Department of Transplantation Surgery, Erasmus University Medical Center, Rotterdam, Netherlands; 2Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands; 3Department of Vascular Surgery, Erasmus University Medical Center, Rotterdam, Netherlands; 4Department of Radiology, Erasmus University Medical Center, Rotterdam, Netherlands.

    Introduction: Kidney transplantation (KTx) is the therapy of choice in patients with end-stage renal disease. Aorto-iliac calcifications (AIC) are a relative contra-indication for KTx, even…
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