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  • 2018 American Transplant Congress

    Facial Allotransplantation: An Early Look at OPTN Data

    J. Wainright,1 L. Levin,2 L. Cendales,3 C. Wholley,1 W. Cherikh,1 D. Klassen,1 B. Pomahac.4

    1United Network for Organ Sharing, Richmond, VA; 2University of Pennsylvania, Philadelphia, PA; 3Duke University School of Medicine, Durham, NC; 4Brigham and Women's Hospital, Boston, MA.

    Craniofacial Vascularized Composite Allograft (VCA) transplantation is a developing area in the field of transplantation. Thirteen craniofacial transplants have been performed in the US since…
  • 2018 American Transplant Congress

    Experience in the Development of a Life-Supporting Large Animal Orthotopic Cardiac Xenotransplant Model

    L. DiChiacchio,1 A. Singh,1 B. Lewis,1 E. Strauss,1 P. Odonkor,1 B. Williams,1 D. Ayares,2 K. Deatrick,1 Z. Kon,1 M. Mohiuddin.1

    1Cardiac Surgery, University of Maryland Medical Center, Baltimore, MD; 2Chief Scientific Office, Revivicor, Inc., Blacksburg, VA.

    Advances in clinical immunosuppression and characterization of optimal donor genetics continue to move the field of xenotransplantation toward a clinical reality with extremely long-term survival…
  • 2018 American Transplant Congress

    MICA/B Polymorphisms and the Relationship of the Matching Degree between MICA/B and HLA of Related Donor-Recipient Pairs in Allo-HSCT

    Y. Sun, Y. Hao, J. Jin, L. Ding, F. Liang, N. Liu, J. Long, X. Zhao, Y. Xi.

    Beijing 307 Hospital, Beijing, China.

    Objective: To explore the distribution characteristics of MICA/B gene polymorphism in the Han Chinese and the relationship of the matching degree between MICA/MICB and HLA…
  • 2018 American Transplant Congress

    Patients with C-aABMR and V-Lesions in Their Renal Transplant Biopsy Have a Superior Response to Treatment

    K. Sablik, M. Clahsen-van Groningen, C. Looman, M. Betjes.

    Erasmus Medical Center, Rotterdam, Netherlands.

    Introduction Chronic active antibody mediated rejection (c-aABMR) in the renal allograft may occur with isolated arteritis. Isolated v-lesions have been associated with an inferior graft…
  • 2018 American Transplant Congress

    A Machine Learning Approach for Prediction of Delayed Graft Function in Deceased Donor Kidney Transplant Recipients

    S. Kawakita,1 A. Waterman,1,2 M. Everly.1

    1Terasaki Research Institute, Los Angeles, CA; 2Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA.

    Introduction:Delayed graft function (DGF) is an early signal of graft injury that is common in deceased donor kidney transplant (DDKT) recipients. Although we have predictive…
  • 2018 American Transplant Congress

    Sirolimus-Based, Prednisone-Free Regimen in Kidney Transplantation: Long Term Results of an Open-Label, Randomized Controlled Trial

    A. Shetty,1 B. Ho,1 V. Mas,2 Y. Kassis,1 S. Park,1 J. Leventhal,1 D. Chhabra,3 L. Gallon.1

    1Northwestern University, Chicago; 2University of Virginia, Charlottesville; 3Advocate Christ Medical Center, Chicago.

    Background: Calcineurin (CNI) nephrotoxicity is implicated in chronic allograft dysfunction and presents an argument for CNI minimizing immunosuppression. We assessed the long-term effects of CNI…
  • 2018 American Transplant Congress

    Influence of Trough Level in Tacrolimus on the Appearance Rate of De Novo Donor Specific Antibody (dnDSA) under Low Dose-Based Tacrolimus Protocol during 7 Years Follow-Up after Renal Transplantation

    H. Ishida,1 K. Tanabe,2 T. Shimizu,1 M. Furusawa.2

    1Organ Transplantation Medicine, Tokyo Women's Medical University, Tokyo, Japan; 2Urology, Tokyo Women's Medical University, Tokyo, Japan.

    Background. Tacrolimus low trough protocol has been adopted at our institution since 2000.The purpose in this study is to investigate the relationship between maintenance trough…
  • 2018 American Transplant Congress

    Comparison of Low Dose and Very Low Dose Extended-Release Tacrolimus / MMF in De Novo Kidney Transplant Recipients- 3 Years Follow-Up

    S. Narumi,1 Y. Watarai,1 N. Goto,2 T. Hiramitsu,1 M. Tsujita,2 M. Okada,1 K. Futamura,2 T. Kobayashi.3

    1Transplant Surgery, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Aichi, Japan; 2Transplant Nephrology, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Aichi, Japan; 3Kidney Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan.

    Recently, once-daily tacrolimus extended-release formulation (TACER) has been accepted in kidney transplantation, however its optimal dosing are not well evaluated. We have validated low dose…
  • 2018 American Transplant Congress

    β-Glucuronidase Gene Expression in Stool Samples Associated with Chronic Allograft Dysfunction in Kidney Transplants

    A. Israni,1,2 D. Knights,3 G. Al-Ghalith,3 A. Muthusamy,2 B. Wu,4 W. Oetting,5 D. Schaldt,2 R. Remmel,5 P. Jacobson,5 For DeKAF Genomics & GEN03 Investigators.1

    1Medicine, HCMC, University of MN (UMN), Minneapolis; 2Minneapolis Medical Research Foundation (MMRF), Mpls; 3Computer Science, UMN, Mpls; 4Biostatistics, UMN, Mpls; 5College of Pharmacy, UMN, Mpls.

    Background: Myocophenolate mofetil (MMF) is a prodrug that is extensively and rapidly converted to the active component, mycophenolic acid (MPA). MPA undergoes extensive enterohepatic recycling…
  • 2018 American Transplant Congress

    Outcomes of Retroperitoneoscopic Live Donor Nephrectomy (RPLDN): Experience of 1100 Cases at a Single Center

    K. Omoto,1,2 M. Okumi,1 Y. Kakuta,1 H. Noguchi,1 K. Unagami,1 M. Inui,1 H. Ishida,1 K. Tanabe.1

    1Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; 2Department of Transplant Surgery, Toda Chuo General Hospital, Toda, Japan.

    INTRODUCTION: Laparoscopic donor nephrectomy is a standard method of donor nephrectomy. We have tried to establish the technique of pure retroperitoneoscopic live donor nephrectomy (RPLDN)…
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