ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Increased Expression of CEACAM1 is Cytoprotective during Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation

    R. Sosa,1 J. Nevarez-Mejia,1 M. Rossetti,1 A. Zarrinpar,2 F. Kaldas,2 C. Lassman,1 B. Naini,1 N. Datta,2 R. Busuttil,2 D. Gjertson,1 J. Kupiec-Weglinski,2 E. Reed.1

    1Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA; 2Surgery, University of California, Los Angeles, Los Angeles, CA.

    Background T cell exhaustion has recently been proposed as an alternative mechanism to prevent memory development and tissue damage arising during ischemia-reperfusion injury (IRI) in…
  • 2018 American Transplant Congress

    A Phase I/II, Double-Blind, Placebo-Controlled Study Assessing Safety and Efficacy of C1 Esterase Inhibitor for Prevention of Delayed Graft Function in Deceased Donor Kidney Transplant Recipients

    S. Jordan,1 J. Choi,1 O. Aubert,2 M. Haas,3 A. Loupy,2 E. Huang,1 A. Peng,1 I. Kim,1 S. Sethi,1 S. Louie,1 D. Puliyanda,1 A. Vo.1

    1Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; 2Paris Translational Research Center for Organ Transplantation, Necker Hospital, Paris, France; 3Pathology, Cedars-Sinai Medical Center, Los Angeles, CA.

    Background: Delayed graft function (DGF)in kidney allograft recipients is traditionally defined as need for dialysis during the first week after transplantation. DGF is related to…
  • 2018 American Transplant Congress

    Comprehensive Assessment of NSAID Use and Potential Nephrotoxicity Risk in Adult Veteran Kidney Transplant Recipients

    J. Chiasson, C. Fominaya, M. Gebregziabher, D. Taber.

    Ralph H Johnson VAMC, Charleston, SC.

    Background: NSAID use is generally recommended to be avoided in kidney transplantation (KTX), but there is paucity in the studies assessing their safety within this…
  • 2018 American Transplant Congress

    A Novel, Dose-Adjusted Tacrolimus Intrapatient Variability Model Identifies High-Risk Kidney Transplant Recipients Better Than Existing Methodologies

    J. Kim, S. Wilson, Y. Song, J. Schwartz.

    Astellas Pharma Global Development, Inc., Northbrook.

    Intrapatient variability (IPV) of tacrolimus trough concentration (TTC) is a risk factor for inferior transplant outcomes. However, assessing IPV is problematic, relying on fixed dose…
  • 2018 American Transplant Congress

    Complement Activating HLA Class 2 Antibodies Are Associated with Poor Renal Allograft Survival; Multicentre Study

    A. Babu,1,2 O. Shaw,5 N. Khovanova,2 S. Griffin,4 D. Briggs,6 N. Krishnan,1 S. Fletcher,1 C. Imray,1 A. Seitz,3 R. Baker,3 M. Wellberry-Smith,3 B. Clarke,3 K. Cullen,3 F. Edwards,4 T. Rees,4 E. Burrows,4 L. Howe,5 R. Vaughan,5 N. Kessaris,7 N. Mamode,7 A. Dorling,7 D. Zehnder,1 R. Higgins,1,2 D. Mitchell,2 S. Daga.2,3

    1Renal Transplantation, University Hospitals Coventry, Coventry, United Kingdom; 2University of Warwick, Coventry, United Kingdom; 3Renal Transplantation, St James University Hospital, Leeds, United Kingdom; 4Renal Transplantation, University Hospital of Wales, Cardiff, United Kingdom; 5H&I, Viapath,, London, United Kingdom; 6H&I, NHSBT, Birmingham, United Kingdom; 7Renal Transplantation, Guys and St Thomas Hospital, London, United Kingdom.

    IntroductionRole of Class I and II pre-formed complement activating antibodies on renal outcomes is not well defined. In this multicentre study, we looked at the…
  • 2018 American Transplant Congress

    New Factors Predicting Delayed Graft Function: A Multi-Center Cohort Study Based on Kidney Donation after Brain Death Followed by Circulatory Death

    Q. Sun,1 H. Zhou,2 M. Lin,3 X. Hua,1 L. Hong,1 Z. Huang,1 N. Na,1 R. Cai,3 G. Wang,2 Q. Sun.1

    1The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; 2The First Affiliated Hospital, Jilin University, Changchun, China; 3The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

    Background. Delayed graft function (DGF) is a common complication following kidney transplantation that exerts an adverse impact on graft outcomes. Donation after brain death followed…
  • 2018 American Transplant Congress

    Having Your Cake and Eating It Too: An Aggressive Protocol for DSA Treatment Does Not Doom Patients to High Infectious Risk

    A. Murthy, A. Karaballa, G. Vranic, B. Javaid, J. Moore, S. Yi, J. Verbesey, P. Abrams, S. Ghasemian, M. Cooper, A. Gilbert.

    Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.

    Introduction: Antibody mediated rejection (AMR) is one of the most difficult complications to treat in kidney transplantation. We previously reported on our experience with an…
  • 2018 American Transplant Congress

    CMV Viremia and Development of CMV-Specific Cytotoxic T-Cells (CMV-Tc) in Pediatric Renal Transplant Recipients

    H. Pizzo, B. Shin, M. Toyoda, S. Jordan, D. Puliyanda.

    Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.

    Background: The use of lymphocyte depleting agents (LDA) for induction immunosuppression among renal transplant (tx) recipients raises concern for the increased susceptibility to viral infections,…
  • 2018 American Transplant Congress

    Impact of Cigarette Smoking on Living Kidney Donor

    Y. Yoon,1 H. Lee,2 J. Na,3 K. Huh,4 M. Kim,4 S. Kim,4 Y. Kim,4 W. Han.3

    1Urology, Hanyang University College of Medicine, Seoul, Korea; 2Urology, National Health Insurance Service Ilsan Hospital, Goyang, Korea; 3Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea; 4Transplantation Surgery, Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.

    Introduction: Smoking is known to result in the decline of renal allograft function and survival of recipients. However, effect of smoking on living kidney donor…
  • 2018 American Transplant Congress

    Results of UNOS Survey on Diagnosis, Treatment and Follow-Up Evaluation of Clinical and Sub-Clinical TCMR and ABMR in Kidney Transplant Recipients

    P. Sood,1 W. Cherikh,2 A. Toll,2 R. Mehta,1 C. Puttarajappa,1 S. Hariharan.1

    1University of Pittsburgh Medical Center, Pittsburgh; 2UNOS, Richmond.

    Management strategies for treatment of rejection post ktx vary among centers. Controlling minor degrees of inflammation can prevent chronic allograft scarring. To study the diverse…
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