Am J Transplant, Volume 18, Suppl 3 Archives - ATC Abstracts

2018 American Transplant Congress
No Deleterious Effect from the Presence of Donor Specific Antibodies (DSA) or Positive Flow Cytometry Crossmatch (FCXM) on the Outcomes of Simultaneous Liver-Kidney (SLK) Transplant Recipients
H. Khamash, A. Kumar, B. Aqel, R. Heilman, A. Jaramillo, K. Reddy, A. Moss.
Mayo Clinic Arizona, Phoenix.
SLK transplant recipients have excellent outcomes that rival kidney alone recipients in terms of graft and patient survival and have better outcomes in terms of…
2018 American Transplant Congress
Medical and Psychosocial Outcomes of Directed and Non Directed Living Liver Donors
J. Steel, S. Ganesh, A. Lai, S. Shen, N. Zharichenko, S. Nawaz, K. Kingsley, M. Dulovich, A. Tevar, C. Hughes, A. Humar.
Surgery, University of Pittsburgh, Pittsburgh, PA.
Background: Few transplant centers accept Good Samaritan living liver donors. The aims of this study were to compare the medical and psychosocial outcomes of directed…
2018 American Transplant Congress
Water-Jet Dissection for Donor Hepatectomy during Living Donor Liver Transplantation
K. Gotoh,¹ H. Eguchi,¹ Y. Iwagami,¹ D. Yamada,¹ T. Asaoka,¹ T. Noda,¹ K. Kawamoto,¹ S. Kobayashi,¹ K. Umeshita,² Y. Doki,¹ M. Mori.¹
¹Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan; ²Health Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Background The most important issue in living donor liver transplantation (LDLT) is donor safety. Although donor hepatectomy has evolved technically over the years, it is…
2018 American Transplant Congress
Extracellular Vesicles Derived from Huc-MSCs Alleviate Rat Hepatic Ischemia-Reperfusion Injury by Suppressing Oxidative Stress and Neutrophil Inflammatory Response
J. Yao,^1,2 J. Cai,^1,2 J. Zheng,^1,2 L. Chen,^1,2 Y. Zhang,^1,2 Y. Yang.^1,2
¹Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Guangzhou, Guangdong, China; ²Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education Institutes, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, .
Mesenchymal stem cells (MSCs) have been reported possessing therapeutic effects on immunoregulation, tissue repair and regeneration from bench to bedside. Extracellular vesicles (EVs) derived from…
2018 American Transplant Congress
An Open-Label Proof-of-Principle Phase 2a Study to Evaluate Autologous Hematopoietic Stem Cell Transplantation for Allogeneic Organ Transplant Tolerance (ASCOTT)
A. Chruscinski,¹ H. Atkins,² M. Macarthur,¹ C. Anne Marie,² D. Grant,¹ C. Bredsen,² E. Renner,¹ L. Lilly,¹ N. Selzner,¹ O. Adeyi,¹ R. Smith,¹ S. Moshkelgosha,¹ A. Humar,¹ S. Juvet,¹ G. Levy.¹
¹Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada; ²Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada.
Background: Long-term survival of recipients of solid organ transplants is hampered by chronic rejection, disease recurrence and immunosuppression-induced toxicity. Self-tolerance is re-established after autologous hematopoietic…
2018 American Transplant Congress
The AKI-Predict-Score: A New Prediction Model for Acute Kidney Injury after Liver Transplantation
M. Kalisvaart,¹ A. Schlegel,¹ I. Umbro,² K. Roberts,¹ D. Mirza,¹ T. Perera,¹ J. Isaac,¹ A. P. Mitterhofer,² J. de Jonge,³ P. Muiesan.¹
¹Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom; ²Internal Medicine, Sapienza University, Rome, Italy; ³Surgery, Erasmus MC University Medical Center, Rotterdam, Netherlands.
BackgroundPostoperative acute kidney injury (AKI) is a frequent complication after liver transplantation and associated with impaired survival rates, chronic kidney disease and higher costs. Although…
2018 American Transplant Congress
Hypothermic Machine Perfusion Protects Rabbit Kidney Graft through Down Regulation SPP1-MMP7 Signaling Axis
Q. Hu,¹ Z. Zhong,¹ S. Xue,¹ W. Liang,¹ J. Lan,¹ J. Liang,¹ Y. Xiong,¹ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, China; ²The 3rd Xiangya Hospital of Central Sourth University, Changsha, China.
Background: Multicenter studies have indicated that hypothermic machine perfusion(HMP) can be used to prolong cold ischemia time with high-quality preservation and allow utilization of kidney…
2018 American Transplant Congress
Carfilzomib and Belatacept Reduces DSA and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation
B. Ezekian, J. Kwun, P. Schroder, M. Manook, J. Yoon, M. Mulvihill, K. Freischlag, J. Cochran, K. Kroning, J. Yi, S. Knechtle.
Duke Transplant Center, Duke University Medical Center, Durham, NC.
Purpose:Sensitized kidney transplant (KT) recipients have poor access to transplantation and inferior outcomes when transplanted. Conventional methods of desensitization remove donor specific antibody (DSA) temporarily,…
2018 American Transplant Congress
Identification of Exosomal Isletokines Released by Pancreatic Islets in Response to Inflammatory Stress
P. Saravanan,¹ G. Yoshimatsu,¹ R. Bhattacharjee,¹ C. Chang,¹ C. Darden,¹ B. Naziruddin,² M. Lawrence.¹
¹Islet Cell Lab, Baylor Scott & White Research Institute, Dallas, TX; ²Transplantation, Baylor Simmons Transplant Institute, Dallas, TX.
Purpose: To identify isletokines released by exosomes from human islets that have been exposed to hypoxic or inflammatory conditions and define stress signaling pathways that…
2018 American Transplant Congress
Everolimus with Reduced-Dose Calcineurin Inhibitor versus Mycophenolate with Standard-Dose Calcineurin Inhibitor in De Novo Kidney Transplant Recipients: Renal Function Results from the TRANSFORM Study
F. Oppenheimer,¹ C. Legendre,¹ J. Cruzado,¹ G. Russ,¹ O. Viklicky,¹ R. Oberbauer,¹ V. Garcia,¹ O. Witzke,¹ D. Kuypers,¹ R. Danguilan,¹ P. Bernhardt,² C. Sommerer.¹
¹TRANSFORM Study Group, Barcelona, Spain; ²Novartis Pharma AG, Basel, Switzerland.
Purpose: TRANSFORM (NCT01950819) is the largest study conducted in de novo kidney transplant recipients (KTxRs) to evaluate the benefit of everolimus with reduced-dose calcineurin inhibitor…

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