ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    RNA Expression Profiling of Renal Allografts in a Non-Human Primate Identifies Inflammation as a Risk Factor in Chronic Antibody Mediated Rejection

    R. Smith,1 B. Adam,2 A. Rosales,1 M. Matsunami,3 T. Oura,3 B. Cosimi,3 T. Kawai,3 M. Mengel,2 R. Colviin.1

    1Pathology, Massachusetts General Hospital, Boston, MA; 2Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; 3Surgery, Massachusetts General Hospital, Boston, MA.

    IntroductionChronic alloantibody mediated rejection (CAMR) is a major risk factor in renal allografts. Some inflammation is commonly identified within CAMR, though mostly low grade, and…
  • 2018 American Transplant Congress

    The Mark of Zorro: IL35-Coated Exosomes Cross-Dress and Exhaust Recipient T & B Cells during Transplant Tolerance

    W. Burlingham,1 J. Sullivan,1 D. Lema,1 Y. Tomita,2 Y. Zhou,1 D. Vignali.3

    1Surgery, University of Wisconsin, Madison, WI; 2Surgery, Tokyo Women's Hospital, Tokyo, Japan; 3Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA.

    The folk-hero "Zorro" left his mark on by a sword-slashed "Z". In transplant recipients, rare Tregs also leave a mark on their conventional T &…
  • 2018 American Transplant Congress

    Comparison of Three Approaches for Laparoscopic Donor Nephrectomy: Transvaginal, Transumbilical Single Site and Retroperitoneal

    M. Miura, H. Higashiyama.

    Department of Urology and Renal Transplantation Surgery, Sapporo Hokuyu Hospital, Sapporo, Japan.

    Objectives: Reduction of burdens to live kidney donors are important. The aim of this study was to compare the surgical outcomes of 3 approaches we…
  • 2018 American Transplant Congress

    Endothelial Cell Heterogeneity Governs Basal and Inducible Inflammatory Responses Relevant to Allograft Injury

    N. Valenzuela.

    Pathology and Laboratory Medicine, UCLA, Los Angeles, CA.

    PurposeTransplanted tissues are differentially susceptible to ischemia/reperfusion and rejection. Endothelial cells (EC) are active regulators of inflammation. But model EC may not adequately reflect the…
  • 2018 American Transplant Congress

    Validation of an Integrative and Dynamic Prognostic Score for Response to Therapy in Solid Organ Transplants

    A. Loupy, O. Aubert, D. Viglietti, C. Legendre, D. Glotz, C. Lefaucheur.

    Paris Translational Center for Organ Transplantation, Paris, France.

    Drug development in transplantation has diminished due to the lack of suitable endpoints for predicting graft failure. We sought to validate the performance of an…
  • 2018 American Transplant Congress

    Pre-Donation Body Mass Index Associations with Outcomes in Living Kidney Donors: A Single Centre Experience

    A. Kousios, K. Koutroutsos, R. Charif, J. Galliford, N. Stubbs, H. Dulku, H. Orr, M. Loucaidou.

    West London Renal and Transplant Centre, Imperial College NHS Trust, London, United Kingdom.

    Background. Living kidney donor (LD) eligibility criteria have expanded as a result of excellent donor outcomes and increasing organ demand. However, considerable variability exists between…
  • 2018 American Transplant Congress

    Do Reconstruction Techniques for Two Renal Arteries Affect Long-Term Graft Survival after Living Donor Renal Transplantation?

    S. Yamanaga, P. Stock, M. Tavkol, S-.M. Kang.

    Transplant Surgery, UCSF, San Francisco, CA.

    Background: Living donor kidneys with two arteries can be revascularized using various techniques depending on anatomy. We hypothesized that the revascularization technique could impact long-term…
  • 2018 American Transplant Congress

    The Financial Impact of the Opioid Epidemic on Kidney Transplantation Readmissions

    L. Wilson, D. Taber, N. Pilch, R. Gilbert, Z. Elmaasarani, B. O'Brien, N. Patel, P. Mauldin, S. Ball, P. Baliga, J. Fleming.

    MUSC, Charleston, SC.

    Research has demonstrated increased annual medical costs in patients who abuse opioids, estimated at up to $18,000 per patient and $29 billion overall in the…
  • 2018 American Transplant Congress

    Development of an Individualized Online Shared Decision Making Tool for Kidney Transplant Candidates

    A. Hart,1,2,3 M. Bruin,1 S. Chu,1 M. Partin,1 A. Matas,1 C. John,1 A. Israni.1,2,3

    1University of Minnesota, Minneapolis; 2Scientific Registry of Transplant Recipients, Minneapolis; 3Hennepin County Medical Center, Minneapolis.

    Background: Inadequate knowledge hinders informed decision making in kidney transplant candidates. We conducted qualitative interviews and focus groups with patients and providers to inform development…
  • 2018 American Transplant Congress

    Robust Hematopoietic Mixed Chimerism and Donor-Specific Skin Allograft Tolerance after Non-Genotoxic Anti-CD117 Immunotoxin Conditioning and Donor Bone Marrow Allotransplantation

    Z. Li,1 A. Czechowicz,2,3,4,5,6,7 A. Scheck,2,3,4,5,6 D. Rossi,3,4,5,6 P. Murphy.1

    1Lab of Molecular Immunology (LMI), NIAID, Bethesda; 2Dept Pediatrics, Div Stem Cell Transplantation and Regenerative Med, Stanford Univ, Stanford; 3Pgram Cellular & Molecular Med, Div Hematology/Oncology, Boston Children's Hosp, Boston; 4Dept Stem Cell & Regenerative Biol, Harvard Univ, Boston; 5Dept Pediatrics, Harvard Med Sch, Boston; 6Harvard Stem Cell Inst, Harvard Univ, Cambridge; 7Dept Pediatric Oncology, Dana Farber Cancer Inst, Boston.

    Establishing hematopoietic chimerism enables donor-specific allograft tolerance; however, chimerism protocols typically require either genotoxic conditioning or mega-doses of donor bone marrow cells (BMC), impeding clinical…
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