Which Is the Predictable Value of Post-Transplant HCC Recurrence Between Tumor-Related Factors at the Initial Diagnosis and the Transplantation?
1Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
2Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea
3Department of Surgery, CHA Bundang Medical Center, CHA University, Bundang, Korea.
Meeting: 2016 American Transplant Congress
Abstract number: A193
Keywords: Hepatocellular carcinoma, Outcome, Survival
Session Information
Session Name: Poster Session A: Liver - Hepatocellular Carcinoma and Cholangiocarcinoma Malignancies
Session Type: Poster Session
Date: Saturday, June 11, 2016
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Background: Milan criteria is best options to decide whether patients with HCC underwent liver transplantation. However, Milan Criteria is not including values at time of fist diagnosis HCC. So it is not useful to apply of down staging, LT after resection, RFA or TACE. This study aimed to know Risk factor of recurrence of HCC at the time of not only liver transplantation but also first diagnosis.
Methods: Medical records of 228 liver recipients with HCC who underwent liver transplantation between Jan 2007 and Dec 2013 were retrospectively reviewed. The difference of disease free survival rate of aboveand Milan Criteria at the time of first diagnosis and liver transplantation were analyzed. AFP and PIVKA at that time were also analyzed.
Results: Among them, 191 Patients who underwent LT with HCC had no recurrence, however 37 patients had recurrence of HCC after LT. There were no significantly difference of gender, HBV, HCV, Donor type and Child- pugh score. In univariate analysis, Milan criteria at first diagnosis, Milan criteria at liver transplantation, AFP≥200 ng/mL at first diagnosis, AFP≥200 ng/mL at liver transplantation, PIVKA≥100 mAU/mL at first diagnosis and PIVKA≥100 mAU/mL at liver transplantation affected HCC recurrence. In multivariate analysis, AFP≥200 ng/mL at liver transplantation, PIVKA≥100 at liver transplantation and AFP≥200 ng/mL at first diagnosis affected disease free survival. (Hazards ratio 3.969, 3.002 and 2.459, respectively)
Conclusion: AFP, PIVKA at liver transplantation is strong risk factor of HCC recurrence. There are also poor prognosis factor that Patients have serum AFP level more than 200 ng/mL at first diagnosis HCC although within Milan criteria at liver transplantation.
CITATION INFORMATION: Lee J, Lee J, Lee J, Song S, Lee J, Kwon S.-K, Ju M, Kim M, Choi G, Choi J, Kim S, Joo D. Which Is the Predictable Value of Post-Transplant HCC Recurrence Between Tumor-Related Factors at the Initial Diagnosis and the Transplantation? Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Lee J, Lee J, Lee J, Song S, Lee J, Kwon S-K, Ju M, Kim M, Choi G, Choi J, Kim S, Joo D. Which Is the Predictable Value of Post-Transplant HCC Recurrence Between Tumor-Related Factors at the Initial Diagnosis and the Transplantation? [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/which-is-the-predictable-value-of-post-transplant-hcc-recurrence-between-tumor-related-factors-at-the-initial-diagnosis-and-the-transplantation/. Accessed May 20, 2025.« Back to 2016 American Transplant Congress