Virological Profile of Deceased Organ Donors in the UK.
1NHSBT/PHE Epidemiology Unit, Public Health England, London, United Kingdom
2NHS Blood & Transplant, London, United Kingdom.
Meeting: 2016 American Transplant Congress
Abstract number: B102
Keywords: Donation, Risk factors, Safety, Screening
Session Information
Session Name: Poster Session B: Donor Management: All Organs
Session Type: Poster Session
Date: Sunday, June 12, 2016
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Background: To date there has been no routine surveillance of infections in deceased solid organ donors in the UK. A national scheme to monitor infectious markers that are routinely screened for in donors has now been established by linking regional donor records, including risk information and an array of serological test results, with a national database. This is the first nationwide analysis of the epidemiology of viral markers in deceased solid organ donors.
Methods: Assessment forms and virology results were requested from regional organ donation teams for all potential organ donors consented between 2010 and 2014. These forms included information about behaviors associated with risk of infection, as reported by a consenting relative, and were linked to a national database containing characteristics for potential donors. Prevalence of confirmed infections was calculated by gender, donor type, age, and ethnicity.
Results: Among 8,272 potential donors with available test results, 124 markers of infection were found – 89 were HBcore positive, 27 HCV, 6 HBsAg, one HIV, and one HTLV. HCV prevalence (0.33%) was similar to the general UK population estimate of 0.4%, while chronic HBV prevalence (0.07%) was lower than the population estimate of 0.3%. The most common risk factor for HBV was being born in an endemic country (32.6%), while for HCV it was injecting drug use (70.4%).
| HBsAg | HBcore | HCV | ||||
| Positive | Prevalence | Positive | Prevalence | Positive | Prevalence | |
| Gender | ||||||
| Male | 4 | 0.09% (0.02-0.22) | 53 | 1.17% (0.88-1.52) | 19 | 0.42% (0.25-0.65) |
| Female | 2 | 0.06% (0.01-0.20) | 36 | 1.01% (0.71-1.39) | 8 | 0.22% (0.10-0.44) |
| Age | ||||||
| <55 | 3 | 0.07% (0.02-0.22) | 39 | 0.99% (0.71-1.35) | 20 | 0.51% (0.31-0.78) |
| 55+ | 3 | 0.07% (0.01-0.21) | 50 | 1.20% (0.89-1.57) | 7 | 0.17% (0.07-0.34) |
| Donor Type | ||||||
| DBD | 6 | 0.16% (0.06-0.35) | 55 | 1.49% (1.12-1.93) | 24 | 0.65% (0.41-0.96) |
| DCD | 0 | 0.00% (0.00-0.08) | 34 | 0.77% (0.53-1.07) | 3 | 0.07% (0.01-0.20) |
| Ethnicity | ||||||
| White | 5 | 0.06% (0.02-0.15) | 66 | 0.87% (0.67-1.11) | 23 | 0.30% (0.19-0.45) |
| Non-white | 1 | 0.27% (0.01-1.47) | 27 | 7.69% (5.13-10.99) | 0 | 0.00% (0.00-0.98) |
| Unknown | 0 | 0.00% (0.00-2.11) | 6 | 3.47% (1.28-7.40) | 4 | 2.30% (0.63-5.78) |
Conclusion: These data will be used to inform risk estimation for disease transmission by transplantation. The national scheme will now be used to monitor annual changes in the demographics of organ donors, and the characteristics of infected donors.
CITATION INFORMATION: Lawrance M, Davison K, Ushiro-Lumb I, Lattimore (deceased) S, Brailsford S. Virological Profile of Deceased Organ Donors in the UK. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Lawrance M, Davison K, Ushiro-Lumb I, (deceased) SLattimore, Brailsford S. Virological Profile of Deceased Organ Donors in the UK. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/virological-profile-of-deceased-organ-donors-in-the-uk/. Accessed November 22, 2024.« Back to 2016 American Transplant Congress