Usefulness of Multi-Detector Computed Tomography (MDCT) Scanning as a Replacement for Diethylenetriamine Pentaacetic Acid (DTPA).
1Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea
2Transplantation Surgery, Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Republic of Korea
Meeting: 2017 American Transplant Congress
Abstract number: D252
Keywords: Renal function
Session Information
Session Name: Poster Session D: Living Donor Kidney Transplant II
Session Type: Poster Session
Date: Tuesday, May 2, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Objective: Diethylenetriamine pentaacetic acid (DTPA) and multi-detector computed tomography (MDCT) can predict postoperative estimated glomerular filtration rate (eGFR) in a live kidney donor. Accordingly, we compared predicted eGFR measured by DTPA and MDCT.
Methods: From January 2013 to May 2015, 264 live kidney donors were enrolled. All donors underwent preoperative DTPA and MDCT, and bilateral renal cortex volume was measured by MDCT. We estimated DTPA-eGFR [remaining split renal function (%) [times] preoperative eGFR] and Vol-eGFR [remaining renal volume/total renal volume (%) [times] preoperative eGFR], and analyzed DTPA-eGFR, Vol-eGFR, and Modification of Diet in Renal Disease (MDRD)-eGFR during week 1 and in months 1, 3, and 6. Additionally, we compared DTPA-eGFR and Vol-eGFR using [Delta]eGFR (maximum eGFR – minimum eGFR during 6 months).
Results: The mean DTPA-eGFR and Vol-eGFR values (ml/minute/1.73 m2) were 52.97±10.32 and 51.26±10.26, respectively.Predictions of the dominant side did not agreed in 113/303 (37.3%) cases. Postoperative MDRD-eGFR exhibited a statistically significant correlation with total renal volume, DTPA-eGFR, and Vol-eGFR (p<0.0001). A significant correlation was found between [Delta]eGFR and total renal volume, DTPA-eGFR, and Vol-eGFR (p<0.0001). Receiver operating characteristic (ROC) curves were generated to predict the possibility of eGFR <60 ml/minute/1.73 m2 at 6 months using DTPA-eGFR and Vol-eGFR, which indicated that DTPA-eGFR (AUC=0.858; p<0.0001) and Vol-eGFR (AUC=0.878; p<0.0001) could predict CKDIII at 6 months.
Conclusion: MDRD-eGFR, Vol-eGFR, and DTPA-eGFR were significantly correlated. Moreover, Vol-eGFR and DTPA-eGFR exhibited high predictive value forCKD III at 6 months, whereas Vol-eGFR was a good predictor of renal function recovery.
CITATION INFORMATION: Lee H, Han W, Huh K, Kim M, Kim S, Kim Y, Yoon Y. Usefulness of Multi-Detector Computed Tomography (MDCT) Scanning as a Replacement for Diethylenetriamine Pentaacetic Acid (DTPA). Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Lee H, Han W, Huh K, Kim M, Kim S, Kim Y, Yoon Y. Usefulness of Multi-Detector Computed Tomography (MDCT) Scanning as a Replacement for Diethylenetriamine Pentaacetic Acid (DTPA). [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/usefulness-of-multi-detector-computed-tomography-mdct-scanning-as-a-replacement-for-diethylenetriamine-pentaacetic-acid-dtpa/. Accessed May 29, 2025.« Back to 2017 American Transplant Congress