ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Use of Hepatitis C Infected Organs for Kidney Transplantation: A Cost-Effective Analysis.

B. Kiberd,1 K. Doucette,2 K. Tennankore.1

1Dalhousie University, Halifax, NS, Canada
2University of Alberta, Edmonton, AB, Canada

Meeting: 2017 American Transplant Congress

Abstract number: D286

Keywords: Allocation, Kidney transplantation, Outcome

Session Information

Date: Tuesday, May 2, 2017

Session Name: Poster Session D: Non-Organ Specific: Economics, Public Policy, Allocation, Ethics

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall D1

Related Abstracts
  • Use of Hepatitis C Infected Organs for Kidney Transplantation: A Medical Decision Analysis.
  • Treating Hepatitis C+ Patients Before or After Kidney Transplantation: A Medical Decision Analysis.

Given that Hepatitis C (HCV) can be cured, organs from HCV+ deceased donors might be used even in HCV- recipients. However HCV treatment is expensive. The purpose of this analysis is to determine whether this strategy is cost effective from the third party payer perspective.

US mortality rates for adult wait-listed, functioning transplant and dialysis cohorts and graft survival rates were used for waitlisted subjects (baseline age 40). Baseline annual dialysis ($82,338), annual transplant ($25,584), first year transplant ($118,669) and one time HCV treatment ($75,000) costs were incorporated into the model. Time 0 was the date of listing, time horizon was 50 years and costs (US$) and life years were discounted at 3%.

Option 1 patients on the waitlist would only opt to be transplanted with a HCV- organ (5 years average wait) only. Option 2 patients would opt to receive either a HCV- or HCV+ organ with the hope of an earlier transplant (average wait 4 years).

The Table shows a 1-way sensitivity analysis that incorporated the possibility that some of those receiving a HCV+ organ might fail therapy. If there was 0% chance of treatment failure then Option2 resulted in more life years at less cost. If 5% of those receiving a HCV+ organ failed treatment, then the benefits were lower and the costs higher with an incremental costs/life year of about $58,000. If the risk of treatment failure remained less than 3%, then Option 2 resulted in more life years at less cost.

Option HCV Treatment

Failure %

Total Cost $ Added Cost ($) Life Years Added Life Years Incremental Cost/LY
Option1

Option2

0% 504,239

497,570

-6,660 9.39

9.437

0.047 Less $ More LY
Option1

Option2

2.5% 504,239

502,084

-2,155 9.39

9.434

0.044 Less$ More LY
Option1

Option2

5% 504,239

506,598

2,358 9.39

9.431

0.041 $57,747/Ly

If HCV treatment cost was higher ($150,000 vs. $75,000), Option2 would still be cost effective (incr. cost/life year of <$100,000) except in older patients (>age 60) who had an incr. cost/life year exceeding $200,000. Incr. cost/life year increased if overall wait times for HCV- organs were shorter or risk of treatment failure increased.

The cost effectiveness of this strategy depends more on a high likelihood of cure rather than HCV treatment costs.

CITATION INFORMATION: Kiberd B, Doucette K, Tennankore K. Use of Hepatitis C Infected Organs for Kidney Transplantation: A Cost-Effective Analysis. Am J Transplant. 2017;17 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Kiberd B, Doucette K, Tennankore K. Use of Hepatitis C Infected Organs for Kidney Transplantation: A Cost-Effective Analysis. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/use-of-hepatitis-c-infected-organs-for-kidney-transplantation-a-cost-effective-analysis/. Accessed January 18, 2021.

« Back to 2017 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • How To Handle a Missed or Delayed Dose Intake? A Pharmacokinetic Study of Cyclosporine and Tacrolimus in Renal Transplant Patients
  • Hyperkalemia in the Early Post Renal Transplant Period

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.