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Two-Week Protocol Biopsy in Renal Allograft: Feasibility, Safety, and Outcomes

M. Lim1, K. Lee2

1Samsung Medical Center, Seoul, Korea, Republic of, 2Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of

Meeting: 2022 American Transplant Congress

Abstract number: 1055

Keywords: N/A, Protocol biopsy, Safety, Screening

Topic: Clinical Science » Kidney » 40 - Kidney Living Donor: Other

Session Information

Session Name: Kidney Living Donor: Other

Session Type: Poster Abstract

Date: Sunday, June 5, 2022

Session Time: 7:00pm-8:00pm

 Presentation Time: 7:00pm-8:00pm

Location: Hynes Halls C & D

*Purpose: Protocol biopsy in renal allograft helps to early detect subclinical rejection (SCR) in patients who have no abnormal clinical and laboratory findings. Still, there are rare reports about the techniques and outcomes of two-week protocol biopsy. The aim of this study was to assess two-week protocol biopsy regarding the technical feasibility, procedure safety, and clinical outcomes.

*Methods: A total of 894 protocol biopsies were performed in adult recipients between 2012 and 2019. Two-week and one-year protocol biopsies were guided with ultrasound in 842 and 399 patients by one of four radiologists with wide range of biopsy experience, respectively. These protocol biopsies were compared in terms of feasibility, safety and SCR. Standard references were clinico-laboratory findings and biopsy examinations.

*Results: The median period of two-week and one-year protocol biopsies were 12 days (10-20 days) and 383 days (302-420 days), respectively. All protocol biopsies were technically successful and there was no difference between radiologists regarding technical success and complications (p = 0.453). Major complication (Clavien-Dindo grading II-IV) rates of two-week and one-year protocol biopsies were 0.3% (3/842) and 0.2% (1/399), respectively (p = 1.000). However, univariate analysis demonstrated that platelet count <100K and blood urea nitrogen ≥40 mg/dL were associated with major complications in two-week protocol biopsy. The SCRs of these protocol biopsies were 15.4 % (130/842) and 33.6 % (134/399), respectively (p < 0.001).

*Conclusions: Two-week protocol biopsy is technically feasible and safe. It contributes to early detecting a substantial number of SCRs. Prior to the biopsy, platelet count and blood urea nitrogen should be carefully checked to predict major complications.

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To cite this abstract in AMA style:

Lim M, Lee K. Two-Week Protocol Biopsy in Renal Allograft: Feasibility, Safety, and Outcomes [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/two-week-protocol-biopsy-in-renal-allograft-feasibility-safety-and-outcomes/. Accessed May 28, 2025.

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