USRDS showed that 1.2% & 1.6% incidences of tuberculosis-TB in patients on peritoneal dialysis and hemodialysis-HD, respectively. Kidney transplant-KTX patients have higher rates.

We studied the epidemiology and outcome of TB in patients with kidney dysfunction-KD in the past decade-2006 to 2015 through an electronic system.

As shown in Figure 1, 581 patients with active TB, of whom 37 had KD including chronic kidney disease, HD, and KTX. No difference was found in the prevalence, age, or gender predilection. The age ranged from 1 to 95 with a mean (standard deviation) of 38.6 (21.1) years. The incidence of TB is 3 per 100,000.The number of patients per year with active TB ranges from 52 to 128 and 3 to 4 in the general population and KD, respectively.

A shown in Figure 2, 65% of patients with KD had pulmonary TB, 5% had pleurisy, and 30% had extrapulmonary TB.Eighty-four percent of patients with KD completed the course of treatment with 16% treatment failure and 0.4% developed multidrug-resistant TB; 8% were lost to follow-up and 8% died during the treatment period. Duration of symptoms before diagnosis of TB was shorter in KD in comparison to the general population. TB cultures were the most positive tests whereas bronchoalveolar lavage and skin test were the least positive for detecting TB in KD.

Improvement in registries and screening is required to enhance the capturing rate and detection among this group, as well as providing accurate data to health authorities and the public about the magnitude, future trends, treatments, and outcomes regarding TB in KD.

CITATION INFORMATION: Metry A., Al Salmi I., Al Ismaili F., Hola A., Shaheen F., Al Salmi I. Tuberculosis among Kidney Transplant Patients Compared to Dialysis and Non-Dialysis CKD Patients over a Decade Period Am J Transplant. 2017;17 (suppl 3).

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