Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall C & D
*Purpose: To establish the rate of positive transport medium fluid cultures and sensitivity to antibiotics in paediatric renal transplant recipients.
*Methods: We analysed the electronic records of 125 renal transplant recipients transplanted at a large paediatric renal transplant centre from January 2012 to December 2017. 36 had deceased donor kidney transplants (DDTx) and 89 has living donor transplants (LDTx). 50 patients were excluded as no culture was sent, leaving 27 DDTx and 48 LDTx patients. We looked into TMF growth and sensitivity to the prophylactic antibiotics used.
*Results: 30% of the DDTx recipients had a positive TMF culture.75% grew a single bacteria and 25% grew multiple organisms (Table 1). Coliforms were the most common bacteria grown(30%). Only 50% of the bacteria were sensitive to the prophylactic antibiotics used at the time (protocol revised from ciprofloxacin to co-amoxiclav in 2017). 60% of growths were sensitive to amikacin, whereas only 30% were sensitive to co-amoxiclav and 27% to ciprofloxacin.
19% of LDTx recipients had a positive TMF culture. 78% grew a single organism and 22% had multiple growth. (Table 2) Coagulase negative staphylococcus was most commonly grown(55%). 36% of the bacteria were sensitive to the prophylactic antibiotics. 64% of cultures were sensitive to amikacin. Only 9% were sensitive to co-amoxiclav and 27% to ciprofloxacin.
*Conclusions: Bacterial growth of TMF cultures differs between DDTx and LDTx. Only 30% of bacteria were sensitive to the prophylactic antibiotics. Amikacin was the antibiotic that most organisms were sensitive to in both groups although there are concerns using aminoglycosides in this patient cohort.
|Bacterial Growth||No. of positive TMF cultures||Sensitive to Prophylactic Antibiotics Used|
|Staphylococcus warneri||2||No, unknown|
|Bacterial Growth||No. of positive TMF Cultures||Sensitive to ProphylacticAntibiotics used|
|Coagulase negative staphylococcus||6||No,no,no,yes, yes, unknown|
To cite this abstract in AMA style:Furnell D, Boyle S, Kessaris N, Marks SD, Stojanovic J. Transport Medium Fluid Cultures in Paediatric Renal Transplantation: Are We Ready to Make a Consensus on Prophylaxis? [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/transport-medium-fluid-cultures-in-paediatric-renal-transplantation-are-we-ready-to-make-a-consensus-on-prophylaxis/. Accessed December 5, 2020.
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