The Impact of Marginal Factors on the Postoperative Kidney Function of Complex Living Donors for Kidney Transplantation.
Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, Japan
Meeting: 2017 American Transplant Congress
Abstract number: A248
Keywords: Donors, Kidney transplantation, marginal, Protocol biopsy, Renal function
Session Information
Session Name: Poster Session A: Living Donor Kidney Transplant I
Session Type: Poster Session
Date: Saturday, April 29, 2017
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Hall D1
Background
Medically complex living donors with marginal factors are increasing.
Methods
Between January 2008 and May 2015, 639 living donors for kidney transplantation were included. Marginal factors for medically complex living donor include hypertension, dislipidemia, glucose intolerance, and obesity. Living donors were stratified with age (20-39 years, 40-59 years, and 60-79 years). The living donors with at least one marginal factor were classified into complex donors. Eleven of 41 donors between 20-39 years, 171 of 296 donors between 40-59 years, and 232 of 302 donors between 60-79 years were complex donors. Pathological findings of control biopsy and postoperative estimated glomerular filtration rates (eGFRs) were compared between complex and healthy donors in each age, retrospectively.
Results
In pathological findings, obsolescent glomerulus or arteriolosclerosis were similarly identified in both donors.
| Pathological findings of control biopsy (obsolenscent glomerulus or arteriolosclerosis) | |||
| Complex donor | Healthy donor | P | |
| 20-39 years | 0 (0%) | 1 (3.3%) | 0.999 |
| 40-59 years | 63 (36.8%) | 36 (28.8%) | 0.148 |
| 60-79 years | 150 (64.7%) | 51 (72.9%) | 0.202 |
In postoperative eGFRs, no significant differences were identified during observation periods.
| Post operative eGFR of donors 20-39 years | ||||||
| Pre ope | 12M | 24M | 36M | 48M | 60M | |
| Complex donor | 87.9 | 58.4 | 56.4 | 57.6 | 60.0 | 54.9 |
| Healthy donor | 92.6 | 57.2 | 59.2 | 60.6 | 59.5 | 58.9 |
| P | 0.377 | 0.743 | 0.481 | 0.596 | 0.934 | 0.571 |
| 40-59 years | ||||||
| Complex donor | 78.8 | 50.1 | 50.5 | 50.0 | 50.1 | 50.7 |
| Healthy donor | 75.5 | 48.2 | 48.6 | 49.6 | 50.2 | 50.1 |
| P | 0.017 | 0.075 | 0.113 | 0.714 | 0.973 | 0.747 |
| 60-79 years | ||||||
| Complex donor | 71.2 | 43.6 | 45.2 | 45.6 | 44.3 | 43.0 |
| Healthy donor | 70.8 | 44.4 | 44.9 | 45.6 | 45.3 | 45.0 |
| P | 0.794 | 0.516 | 0.812 | 0.976 | 0.618 | 0.485 |
Conclusion
Postoperative kidney function of complex donors can be maintained similarly to those of healthy donors.
CITATION INFORMATION: Hiramitsu T, Futamura K, Okada M, Tsujita M, Goto N, Narumi S, Watarai Y. The Impact of Marginal Factors on the Postoperative Kidney Function of Complex Living Donors for Kidney Transplantation. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Hiramitsu T, Futamura K, Okada M, Tsujita M, Goto N, Narumi S, Watarai Y. The Impact of Marginal Factors on the Postoperative Kidney Function of Complex Living Donors for Kidney Transplantation. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/the-impact-of-marginal-factors-on-the-postoperative-kidney-function-of-complex-living-donors-for-kidney-transplantation/. Accessed November 21, 2024.« Back to 2017 American Transplant Congress