The Evaluation of Living-Related Kidney Transplantation Donors in Autosomal-Dominant Polycystic Kidney Disease
1Urology, Kindai University Hospital, Osaka, Japan, 2Organ transplant medicine, Tokyo Women's Medical University Hospital, Tokyo, Japan, 3Urology, Tokyo Women's Medical University Hospital, Tokyo, Japan
Meeting: 2021 American Transplant Congress
Abstract number: 966
Keywords: Kidney transplantation
Topic: Clinical Science » Kidney » Kidney Living Donor: Other
Session Information
Session Name: Kidney Living Donor: Other
Session Type: Poster Abstract
Session Date & Time: None. Available on demand.
Location: Virtual
*Purpose: Autosomal-dominant polycystic kidney disease (ADPKD) is a progressive hereditary disease caused primarily by gene mutations, leading to multiple kidney cyst occurrence, kidney function deterioration, and end-stage renal disease (ESRD). The gene mutations have been identified as PKD1 and PKD2, however, genetic testing is not commonly available; therefore, diagnosis of ADPKD, including work-up for kidney transplantation (KTx) recipients, is usually done through history taking and imaging tests such as computed tomography and/or ultrasound examination. In KTx, blood-relative donors who have the PKD1 and PKD2 gene mutation have an increased risk of developing ADPKD with worsening renal function after nephrectomy. However, these donors’ pre-KTx work-up also involves imaging, renal function tests, etc., and does not include genetic testing. We retrospectively investigated the post-operative outcomes of living KTx donors whose recipients’ etiology of ESRD were ADPKD.
*Methods: We evaluated a total of 90 patients who received KTx from living donors at the Department of Urology of Tokyo Women’s Medical University between 2000 and 2020. For the donor type, blood relative groups in 37 cases and non-blood relative (which represents, spouses, fathers, mothers, brothers, sisters, and sons-in-law) in 53 cases were enrolled in this study.
*Results: There were no significant differences in renal function between the two groups (graft failure: two cases (5.4%) in the blood relative group, and three cases (5.6%) in non-blood relative group). New occurrence and/or enlargement of renal cysts in allograft for recipients from blood relative donors have been observed in four cases without renal function deterioration. For blood donors, there was no occurrence of renal cysts or deterioration of renal function (eGFR: 45.1±7.6ml/min/1.73 m2).
*Conclusions: For blood-relative KTx donors whose recipients have ADPKD, there is stable renal function with no occurrence of renal cysts. Therefore, the outcome of this study indicates that KTx can be performed with minimal risk of developing ADPKD after KTx in living-relative donors.
To cite this abstract in AMA style:
Kikuchi T, Unagami K, Kobari Y, Yagisawa T, Kanzawa T, Omoto K, Uemura A, Ishida H, Tanabe K. The Evaluation of Living-Related Kidney Transplantation Donors in Autosomal-Dominant Polycystic Kidney Disease [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/the-evaluation-of-living-related-kidney-transplantation-donors-in-autosomal-dominant-polycystic-kidney-disease/. Accessed May 11, 2025.« Back to 2021 American Transplant Congress