*Purpose: This study aimed to determine the association of health literacy with pre-transplant health-related quality of life (HRQOL) in adults evaluated for potential listing for solid organ transplantation.

*Methods: Data were collected at pre-transplant evaluation using the Physical Component and Mental Component Summary (PCS, MCS) scores of the SF-36 Health Survey, and the Short Literacy Survey (SLS). Higher SF-36 scores represent better HRQOL (general population mean 50±10). SLS scores range from 0 to 12 with higher scores representing more limited health literacy. Multivariable logistic regression models that adjusted for age, gender, educational attainment and organ type evaluated the association of limited health literacy with PCS and MCS being below general population norms (<40).

*Results: The sample included 1,189 adults (40% female, 68% white, age=54±12 years, 9% *Conclusions: Limited health literacy is associated with an increased likelihood of impaired physical and mental HRQOL. Identifying patients with limited health literacy in the transplant evaluation stage may provide an opportunity for early intervention to improve HRQOL throughout the evaluation and waitlist process.

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