*Purpose: Liver disease is one of the main causes of chronic disease morbidity and mortality in the world and liver transplantation is the only curative intervention once patients reach the terminal stage. We describe the experience our center during 15 years of performing liver transplantation in adults. Our objective was to carry out a descriptive analysis of our population, as well as a survival analysis that allowed us to compare ourselves with international standards.

*Methods: This is a retrospective report which includes a cohort of adult patients who went into liver transplantation from 2005 to July 2020 at the Fundacion Cardioinfantil. We performed a descriptive analysis evaluating patient survival using the Kaplan Meyer method.

*Results: This study included 532 patients, 97% undergoing transplantation with a deceased donor and 3% with a living donor, 50.1% were women and the remaining were men. The mean age at the time of transplantation was 52.3 years. The main indication for transplantation was non-cholestatic cirrhosis, the majority of the patients had a MELD Score less than 15. 6% of the patients were transplanted in acute liver failure. Overall survival was 89.3%, 84.9%, 81.9%, at the 1st, 3rd and 5th year respectively.

*Conclusions: Patients undergoing liver transplantation in our center have had satisfactory results comparable with international standards. This is explained by the multidisciplinary work, the experience acquired during more than 15 years, the development and update in surgical techniques, immunosuppression regimens, organ allocation, donor selection, optimization of pre-operative status, and postoperative surveillance.

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