Superior Outcomes of Kidney Transplantation Compared With Dialysis in Korea: A Propensity–Matched Analysis of a National Population-Based Cohort Study Between 2005 and 2008
1Internal Medicine, Seoul National University Hospital, Seoul, Korea
2School of Public Health, Seoul National University, Seoul, Korea
3Internal Medicine, Hallym University Hangang Sacred Heart Hospital, Seoul, Korea
4Dental Hygiene, College of Health Science, Eulji University, Daejeon, Korea
5Public Health, Graduate School, Korea University, Seoul, Korea
6Internal Medicine, Wonkwang University College of Medicine Sanbon Hospital, Sanbon, Korea
7Internal Medicine, Ewha Womans University Hospital, Seoul, Korea
8Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.
Meeting: 2015 American Transplant Congress
Abstract number: A46
Keywords: Kidney transplantation, Mortality
Session Information
Session Name: Poster Session A: Delayed Function/Acute Injury/Outcomes/Glomerulonephritis
Session Type: Poster Session
Date: Saturday, May 2, 2015
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Exhibit Hall E
Background: Kidney transplantation (KT) can improve clinical outcomes in patients with end-stage renal disease. However, the data about KT outcome comparing with dialysis is rare in Asian population. Here, we evaluated survival and cardiovascular benefits of KT in Asian using the claim data of Korean national public health insurance program.
Method: Among 35,418 all the incident adult dialysis patients between 2005 and 2008 in Korea, 1,539 patients who underwent KT were compared with patients maintaining dialysis before and after 1:1 matching of propensity score. Overall survival rate and post-transplant major adverse cardiovascular event (MACE) were traced.
Results: Before matching, dialysis group was older and had more comorbidities. After matching, there were no difference in age, sex, dialysis modalities, and comorbidity. Patient's survival in transplant group was significantly better than in matched-dialysis group by Gehan-Wilcoxon test (P <0.001). Multivariate analysis also showed that KT significantly decreased risk of death after adjusting for age, sex, and comorbidities (P <0.001, hazard ratio [HR] 0.16, 95% confidence interval [CI] 0.11-0.22). In addition, transplant group showed a better MACE-free survival compared with dialysis-maintaining group (P <0.001, HR 0.19, 95% CI 0.13-0.29).
Conclusion: Long-term dialysis had significantly higher cardiovascular outcome and all-cause mortality compared with KT in Korean incident dialysis patients. Kidney transplant could be recommended more actively in Korean population.
To cite this abstract in AMA style:
Yoo K, Kim C, Lee J, Kim M-H, Cho H, Kim K, Kim H, Ryu D-R, Kim D, Lim C, Kim Y, Lee J. Superior Outcomes of Kidney Transplantation Compared With Dialysis in Korea: A Propensity–Matched Analysis of a National Population-Based Cohort Study Between 2005 and 2008 [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/superior-outcomes-of-kidney-transplantation-compared-with-dialysis-in-korea-a-propensitymatched-analysis-of-a-national-population-based-cohort-study-between-2005-and-2008/. Accessed November 21, 2024.« Back to 2015 American Transplant Congress