ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Simultaneous Liver-Kidney Transplantation is Accompanied by Significant Return of Native Renal Function as Demonstrated by Mag3 Scan

G. Werneburg, D. Goldfarb, R. Fatica, E. Poggio, Y. Lin, M. Eltemamy, A. Wee

Cleveland Clinic, Cleveland, OH

Meeting: 2022 American Transplant Congress

Abstract number: 1079

Keywords: Kidney/liver transplantation

Topic: Clinical Science » Liver » 52 - Liver: Kidney Issues in Liver Transplantation

Session Information

Session Name: Liver: Kidney Issues in Liver Transplantation

Session Type: Poster Abstract

Date: Sunday, June 5, 2022

Session Time: 7:00pm-8:00pm

 Presentation Time: 7:00pm-8:00pm

Location: Hynes Halls C & D

*Purpose: Simultaneous liver-kidney transplant (SLK) has become an increasingly popular option due to commonly comorbid renal insufficiency in liver failure,. Following SLK, it is unknown whether improvement in renal function is due to function of the transplant kidney, return of function of the native kidneys, or both. We sought to determine the return of native renal function following SLK and investigate predictive factors.

*Methods: Following SLK, patients underwent Mag-3 scan following their serum creatinine nadir as part of a quality initiative, and review of the cohort was IRB-approved. Relative contribution of each kidney was calculated based on Mag-3 and eGFR. Patients with good return of native renal function (native contribution eGFR≥30) were compared to those with poor return of native renal function (native contribution eGFR<30) using descriptive statistical analysis, and a final logistic regression model and ROC curve were generated.

*Results: 31 of 34 patients who underwent SLK from August 2019 to May 2021 at our institution were included in analysis. 3 patients had no Mag-3 performed due to scheduling/logistical issues. At baseline, 42% of patients had ESRD, 29% had CKD4/5, and 29% had CKD3. Following SLK, average native-only kidney contribution to overall renal function was 51.1%, corresponding to average native-only eGFR 44.5 (SD 15.2). The transplant kidney’s contribution to overall renal function was 49.0%. 26 of 31 (83.9%) patients had native kidney-only contribution of eGFR of 30 (CKD3) or better. Hepatorenal syndrome, without other original disease was a significant predictor of good return of native renal function (OR 32.0, 95% CI: 1.56 – 656, p=0.025). The final model, which also included preoperative CKD4 or better, was accurate with 93.5% of the cases predicted correctly (p=0.0003). The associated area under the ROC curve was 0.95 (CI: 0.86 – 1.0, Figure).

*Conclusions: Simultaneous liver-kidney transplantation was frequently accompanied by return of native renal function. Hepatorenal syndrome without other original disease was a predictor of good return of native renal function. Randomized trials are needed to determine which patients would be best suited for SLK versus liver transplant alone, with the later option for subsequent kidney transplant via the safety net mechanism.

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Werneburg G, Goldfarb D, Fatica R, Poggio E, Lin Y, Eltemamy M, Wee A. Simultaneous Liver-Kidney Transplantation is Accompanied by Significant Return of Native Renal Function as Demonstrated by Mag3 Scan [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/simultaneous-liver-kidney-transplantation-is-accompanied-by-significant-return-of-native-renal-function-as-demonstrated-by-mag3-scan/. Accessed May 8, 2025.

« Back to 2022 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences