Serum Uric Acid Is Associated With Hypertension in Kidney Donors

S. Reule,¹ R. Foley,¹ A. Matas,² H. Ibrahim.¹

¹Department of Medicine, University of Minnesota, Minneapolis, MN
²Department of Surgery, University of Minnesota, Minneapolis, MN.

Meeting: 2015 American Transplant Congress

Abstract number: A186

Keywords: Hypertension, Kidney transplantation, Outcome, Proteinuria

Session Information

Session Name: Poster Session A: Kidney: Cardiovascular and Metabolic

Session Type: Poster Session

Date: Saturday, May 2, 2015

Session Time: 5:30pm-7:30pm

Presentation Time: 5:30pm-7:30pm

Location: Exhibit Hall E

Introduction:

Uric acid has been linked to the development of hypertension and possibly CKD. Moreover, some preliminary data suggests that lowering uric acid maybe associated with a slower progression of kidney disease. The relationship between uric acid and CKD is highly confounded as CKD patients have many comorbid conditions that even the most sophisticated mathematical adjustments can not account for; residual confounding. Former kidney donors who simply have reduced GFR by virtue of nephrectomy provide a unique opportunity to study this issue.

Methods:

A total of 214 kidney donors underwent formal GFR assessment. Demographic and laboratory variables were obtained. Logistic regression for odds ratios adjusted (AOR) for age, sex, race, ethnicity, serum uric acid, donation eGFR and donation BMI were calculated for binary outcomes including hypertension, proteinuria and GFR < 45 ml/min.

Results:

The mean age (SD) was 48.8 years (10.7) with an average follow up time of 20.5 years (9.0), 60.8% were male, 98.1% were Caucasian and 78.5% donated to related recipient. Both serum uric acid level (AOR 1.59; p = 0.01) at GFR assessment and donation BMI (AOR 1.12; p = 0.01) were associated with hypertension. Only eGFR at donation was associated with proteinuria (AOR 0.77; p < 0.001). There did not appear to be an independent uric acid effect on GFR outcome (AOR 1.43; 0.96-2.14, p = 0.08).

Conclusions:

In kidney donors who underwent formal GFR assessment, serum uric acid level was not associated decreased GFR or proteinuria, however uric acid level was associated with hypertension.

Adjusted Odds Ratios (AOR) for Outcomes at GFR assessment.
	Hypertension		Proteinuria		GFR < 45 ml/min
Characteristic	AOR	p-value	AOR	p-value	AOR	p-value
Male	0.79 (0.37-1.72)	0.56	2.12 (0.15-29.42)	0.58	0.99 (0.36-2.77)	0.99
*Age	1.03 (0.99-1.07)	0.15	1.03 (0.93-1.14)	0.54	0.97 (0.92-1.02)	0.18
Uric acid	1.59 (1.15-2.21)	0.01	1.17 (0.46-2.96)	0.74	1.43 (0.96-2.14)	0.08
*eGFR	1.01 (0.98-1.04)	0.62	0.77 (0.65-0.91)	0	0.99 (0.96-1.04)	0.79
*BMI	1.12 (1.02-1.22)	0.01	0.90 (0.66-1.24)	0.53	0.96 (0.84-1.09)	0.52

*Values at donation

To cite this abstract in AMA style:

Reule S, Foley R, Matas A, Ibrahim H. Serum Uric Acid Is Associated With Hypertension in Kidney Donors [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/serum-uric-acid-is-associated-with-hypertension-in-kidney-donors/. Accessed June 21, 2025.

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