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Quantification of Center Aggressiveness in Accepting Sub-Optimal Kidney Donations from Deceased Donors in the US

T. P. Chiang1, M. Eagleson1, A. Massie1, M. Krach1, D. Segev1, J. Garonzik Wang2

1Department of Surgery, Johns Hopkins University, Baltimore, MD, 2School of Medicine and Public Health, University of Wisconsin, Madison, WI

Meeting: 2022 American Transplant Congress

Abstract number: 313

Keywords: Donors, marginal, Kidney transplantation, Organ Selection/Allocation, Resource utilization

Topic: Clinical Science » Kidney » 50 - Health Equity and Access

Session Information

Session Name: Health Equity and Access I

Session Type: Rapid Fire Oral Abstract

Date: Monday, June 6, 2022

Session Time: 5:30pm-7:00pm

 Presentation Time: 6:40pm-6:50pm

Location: Hynes Ballroom C

*Purpose: Understanding center-level differences in usage of marginal deceased-donor kidneys (suboptimal kidneys, SOK) can help centers increase their deceased-donor transplant rate (DDKT), and to direct SOK offers to centers willing to accept them.

*Methods: We studied 5,646,748 offers of 8,539 SOK donors from 1/1/2018-12/31/2019 using SRTR data. Pediatric centers, center annual volume<1, or multiple match-runs were excluded. We defined SOK offer as: age>60, cold ischemia time (CIT)>24 hours, hepatitis C (HCV), serum creatinine (SCr)>2.0 mg/dL, donated after cardiac death (DCD), KDPI>85, or infectious risk donors (IRD). We used multilevel logistic regression to calculate the median odds ratio (MOR), a measure of center-level variation, for each subtype of SOK.

*Results: There were 18,471 (64%) SOK among 28,676 DDKT performed. Among 197 centers, the percentage of SOK acceptance ranged from 0 to 44.7% with the median (IQR) of 10.6% (6.9%, 14.6%). The SOK subtype with the least center-level variance was DCD (acceptance range: 0-95%, median [IQR]: 10.2% [6.4%, 15.9%], MOR=2.11) and IRD (acceptance range: 0-63.6%, median [IQR]: 16.0% [9.2%, 22.5%], MOR=2.11). The SOK subtype with the most center-level variance was CIT>24 (acceptance range: 0-55.1%, median [IQR]: 2.7% [0.8%, 6.6%], MOR=3.15). For comparison, the MOR of non-SOK kidneys was 1.90.

Numbers of DDKT Donors, Offers and MOR by SOK Category
results transplants performed eligible donors median (IQR) # of offers per donor median (IQR) acceptance rate by center MOR
age>60 1814 822 289 (41, 1129) 4.8 % (1.8 %, 8.5 %) 2.30
CIT>24 H 3031 1179 140 (8, 1204) 2.7 % (0.8 %, 6.6 %) 3.15
HCV (+) 2483 1023 13 (5, 61) 10.5 % (2.9 %, 20.4 %) 2.70
SCr>2.0 4005 1675 93 (12, 512) 7.6 % (3.2 %, 13.3 %) 2.51
DCD 7173 3260 23 (6, 254) 10.2 % (6.4 %, 15.9 %) 2.11
KDPI>85 2629 1170 310 (64, 1220) 3.5 % (1.1 %, 6.9 %) 2.57
IRD 7809 659 12 (5, 69) 16 % (9.2 %, 22.5 %) 2.11

*Conclusions: There was substantial center-level variation in acceptances of SOK offers for each of the SOK subtype categories. Informing centers of donor phenotypes for which that center’s acceptance rate is lower than the national average may motivate centers to accept more marginal kidneys, improving access to DDKT for patients at those centers.

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To cite this abstract in AMA style:

Chiang TP, Eagleson M, Massie A, Krach M, Segev D, Wang JGaronzik. Quantification of Center Aggressiveness in Accepting Sub-Optimal Kidney Donations from Deceased Donors in the US [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/quantification-of-center-aggressiveness-in-accepting-sub-optimal-kidney-donations-from-deceased-donors-in-the-us/. Accessed May 30, 2025.

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