Prediction of Renal Allograft Chronic Rejection Using a Model Based on Contrast Enhanced Ultrasonography

C. Yang¹, T. Zhu¹, W. He²

¹Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China, ²Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China

Meeting: 2019 American Transplant Congress

Abstract number: C140

Keywords: Kidney transplantation, Renal function, Ultrasonography

Session Information

Session Name: Poster Session C: Kidney Technical

Session Type: Poster Session

Date: Monday, June 3, 2019

Session Time: 6:00pm-7:00pm

Presentation Time: 6:00pm-7:00pm

Location: Hall C & D

*Purpose: To evaluated the application of contrast enhanced ultrasonography (CEUS) in diagnosis of renal allograft chronic rejection (CR).

*Methods: Sixty-six renal transplantation recipients were enrolled in the training group, while 38 were recruited in the validation group. Before biopsy, all patients received ultrasound examination.

*Results: In the CR group, rising time (RT) and time to peak (TTP) of medulla (RTm and TTPm) were significantly longer compared to that in the AR group. The kidney volume was significantly decreased in the CR group, but was increased in the AR group. In the training group, age, kidney volume change and TTPm were identified as independent predictors by multivariate analysis. Based on the multivariate analysis results and area under receiver operating characteristic curves (AUROCs) of individual markers, we constructed a new simple index, P = -5.424 + 0.074 × age – 9.818 × kidney volume change + 0.115 × TTPm; New Index = eP / (1 + eP), to discriminate CR, which had better AUROCs than age, kidney volume change or individual CEUS parameters. Similar results were obtained in the validation group.

*Conclusions: In conclusion, the new index provides a new diagnosis model for CR.

To cite this abstract in AMA style:

Yang C, Zhu T, He W. Prediction of Renal Allograft Chronic Rejection Using a Model Based on Contrast Enhanced Ultrasonography [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/prediction-of-renal-allograft-chronic-rejection-using-a-model-based-on-contrast-enhanced-ultrasonography/. Accessed May 8, 2025.

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