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Pre-Treatment Lymphocyte Status in HCC Patients Associates with DEB-TACE Response and Correlates with Increased Regulatory Immune Cells

K. Nunez1, T. Sandow2, S. Robertson1, P. Thevenot1, A. Cohen1

1Ochsner Health System, New Orleans, LA, 2Interventional Radiology, Ochsner Health System, New Orleans, LA

Meeting: 2019 American Transplant Congress

Abstract number: B65

Keywords: CD3

Session Information

Session Name: Poster Session B: Biomarkers, Immune Monitoring and Outcomes

Session Type: Poster Session

Date: Sunday, June 2, 2019

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall C & D

*Purpose: Hepatocellular carcinoma (HCC) recurrence after transplantation is associated with higher tumor grade on explant, failure to respond to DEB-TACE, and pretreatment lymphopenia. We prospectively monitored HCC patients in transplant evaluation to investigate associations between lymphopenia and tolerance with treatment response and waitlist outcomes.

*Methods: HCC patients undergoing DEB-TACE were prospectively enrolled. Blood was collected before and after DEB-TACE (100-300µm LC Beads with 100mg doxorubicin). Peripheral blood mononuclear cells were analyzed by flow cytometry. Tumor response to DEB-TACE was determined using mRECIST imaging criteria. Intention-to-treat (ITT) endpoint included transplantation or tumor progression.

*Results: Analyzed were 74 patients with a median age 61, predominantly Caucasian (75%) with Hepatitis C (76%). Prior to DEB-TACE, 46% of patients were lymphopenic (absolute lymphocyte count, ALC≤1.2k/μL). Tumor response was available in 68 patients. Lymphocyte status remained stable after DEB-TACE with no association between the change in ALC and treatment response. However, pre-treatment ALC and lymphopenia status were associated with failure to response to DEB-TACE (P=0.028, P=0.004). Overall, 68% of patients that did not respond to treatment were lymphopenic. ALC was negatively correlated with tolergenic immune populations, myeloid derived suppressor cells (R2=0.16) and regulatory T cells (Tregs, R2=0.22) and significantly elevated in lymphopenic patients (P=0.02 and P=0.001). Over half of cohort reached ITT endpoint with 26/41 transplanted and 18/41 having tumor progression. In the ITT cohort, 62% of patients that did not respond to DEB-TACE treatment experienced tumor progression.

*Conclusions: Pre-treatment assessment of lymphocytes in early stage HCC patients associates with DEB-TACE treatment response and can identify patients both at risk of tumor progression and recurrence post-transplant.

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To cite this abstract in AMA style:

Nunez K, Sandow T, Robertson S, Thevenot P, Cohen A. Pre-Treatment Lymphocyte Status in HCC Patients Associates with DEB-TACE Response and Correlates with Increased Regulatory Immune Cells [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/pre-treatment-lymphocyte-status-in-hcc-patients-associates-with-deb-tace-response-and-correlates-with-increased-regulatory-immune-cells/. Accessed May 9, 2025.

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