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Pre-Transplant Sarcopenia is Associated with Increased Post-Transplant Mortality

A. Gupta1, T. Norris2, R. Montgomery1, S. Chakraborty1, T. Thomas1, D. Cibrik1, J. Klein1, M. Gupta1, N. Herrera1, T. Schmitt1, A. Nawabi1, J. Mahnken1

1University of Kansas Medical Center, Kansas City, KS, 2University of Kansas School of Medicine, Kansas City, KS

Meeting: 2020 American Transplant Congress

Abstract number: D-035

Keywords: Kidney, Kidney transplantation, Mortality, Risk factors

Session Information

Session Name: Poster Session D: Kidney: Cardiovascular and Metabolic Complications

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: Muscle wasting and sarcopenia in kidney disease is associated with increased cardiovascular events, morbidity and mortality. Psoas muscle cross-sectional area measured on a CT image is a validated method of assessing sarcopenia in kidney disease. Here, we evaluated whether pre-transplant sarcopenia (measured by psoas muscle cross sectional area) is associated with post-transplant adverse outcomes.

*Methods: We conducted a single-center study to evaluate the association of pre-transplant sarcopenia with 3-month post-transplant re-hospitalization rates, graft loss and mortality. We measured the cross-sectional area of the psoas muscle at L4 from a pre-transplant CT scan closest to the date of transplant and compared it to post-transplant outcomes. We used a Cox proportional hazard model to analyze the association of psoas muscle cross-sectional area with graft loss, re-hospitalization and mortality.

*Results: Of the patients transplanted at our center between 2008-2017, 574 had pre-transplant CT images which we could use to calculate the psoas cross sectional area. Table 1 describes the demographic characteristics of the included patients. Psoas muscle cross sectional area was not associated with graft survival or rehospitalization rate. A lower psoas muscle cross sectional area was associated with a higher hazard for death (β coeff=-1.05e-03, p= 0.01), i.e. every increase of 100 mm2 in the psoas muscle cross sectional area decreases the hazard of death by 90%.

*Conclusions: Pre-transplant sarcopenia is associated with increased mortality post-transplant.

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To cite this abstract in AMA style:

Gupta A, Norris T, Montgomery R, Chakraborty S, Thomas T, Cibrik D, Klein J, Gupta M, Herrera N, Schmitt T, Nawabi A, Mahnken J. Pre-Transplant Sarcopenia is Associated with Increased Post-Transplant Mortality [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/pre-transplant-sarcopenia-is-associated-with-increased-post-transplant-mortality/. Accessed May 11, 2025.

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