Pre-transplant Lower Urinary Tract Dysfunction in Men is a Risk Factor for Adverse Outcomes Following Renal Transplantation
1Organ Transplant, Hackensack University Medical Center, Hackensack, NJ, 2Patient Safety and Quality, Hackensack University Medical Center, Hackensack, NJ, 3Urology, Hackensack University Medical Center, Hackensack, NJ
Meeting: 2021 American Transplant Congress
Abstract number: 467
Keywords: Kidney transplantation
Topic: Clinical Science » Infectious Disease » Kidney Infectious Non-Polyoma & Non-Viral Hepatitis
Session Information
Session Time: 7:30pm-8:30pm
Presentation Time: 7:50pm-8:00pm
Location: Virtual
*Purpose: The expanding age criteria for candidacy for renal transplantation, in conjunction with prolonged waiting time for deceased donor kidneys has created new challenges for men with benign prostatic hyperplasia (BPH) and lower urinary tract dysfunction (LUTD). The prevalence of LUTD in the end-stage renal disease male population has not been well characterized. Furthermore, it is unclear how pre-transplantation LUTD should be treated and whether there is post-transplant benefit for risk reduction. Thus, the objective of this study is to characterize the prevalence of pre-transplant LUTD in male candidates for renal transplantation and its contribution to post-transplant outcomes.
*Methods: A single center retrospective study investigated 208 male kidney recipients. We defined LUTD as meeting at least one of following criteria: frequency/urgency, obstructive symptoms, urinary retention, urinary incontinence or bladder outlet obstruction.
*Results: 46 (22.1%) patients had pre-transplant LUTD. Patients with pre-transplant LUTD were four times more likely to experience post-transplant LUTD compared with patients without pre-transplant LUTD (52.2% vs. 13.0%; p<0.01). Patients with post-transplant voiding dysfunction were also over four times more likely to develop a urinary tract infection compared with patients without post-transplant voiding dysfunction (37.8% vs 8.6%; p<0.01). Furthermore, older patients are more likely to have post-transplant LUTD compared to younger patients (p<0.05). Diabetes, anuria/oliguria, and history of previous urinary infection did not significantly predict post-transplant LUTD in univariate analysis.
*Conclusions: Pre-transplant LUTD is a significant predictor for development of post-transplant LUTD leading to higher risk of post-transplant urinary tract infection. Further study is warranted to investigate whether interventions to reduce pre-transplant LUTD or peri-transplant LUTD can reduce the incidence of urinary tract infections and complications after transplantation.
To cite this abstract in AMA style:
Goldstein MJ, Schleich BR, Carrea T, Yushkov Y, Cheng N, Harrison R, Munver R, Fromer D. Pre-transplant Lower Urinary Tract Dysfunction in Men is a Risk Factor for Adverse Outcomes Following Renal Transplantation [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/pre-transplant-lower-urinary-tract-dysfunction-in-men-is-a-risk-factor-for-adverse-outcomes-following-renal-transplantation/. Accessed November 21, 2024.« Back to 2021 American Transplant Congress