Perioperative Bacterial Colonization and Postoperative Urinary Tract Infection in Kidney Transplant Recipients
1Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea
2Department of Surgery, Myongji Hospital, Goyang-si, Gyeonggi-do, Republic of Korea
3Korean Organ Donation Agency, Seoul, Republic of Korea.
Meeting: 2015 American Transplant Congress
Abstract number: A77
Keywords: Infection
Session Information
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Exhibit Hall E
Background. Urinary tract infection (UTI) is the most common infection after kidney transplantation, and one of the source of the infection is thought to be the pre-colonized organism. However the actual extent and clinical implication of bacterial colonization in kidney transplant patients are not well known. We therefore investigated the perioperative colonization status of patients undergoing kidney transplantation and assessed its association with postoperative UTI.
Methods. The surveillance culture results of 318 patients who underwent kidney transplantation from July 2005 to June 2009 were reviewed. Mid-stream urine culture and swab culture of genital area were collected less than 48hours before the operation, and the cultures of urinary catheter were performed on its removal at postoperative 3rd to 5th day. The colonization status of possible pathogens of UTI was assessed and its relationship with UTI after operation was studied.
Results. 62 patients (1.94%) developed UTI during 81±21.6 months of follow up after transplantation. 11 causal organisms were identified through positive urinary cultures at the time of the infection. The most common organism was Escherichia coli (n=38, 50.7%), followed by Klebsiella pneumonia (n=16, 21.6%), Pseudomonas aeruginosa (n=6, 8.0%), and Enterococcus faecalis. In 33, 240, and 130 patients, cultures of preoperative urine sample, preoperative genital area swab sample, postoperative urinary catheter respectively revealed one or more colonized bacteria. Although colonization itself did not increase the risk of UTI, colonization of the any of the four above-mentioned common pathogens showed significant association with postoperative UTI (p=0.002). However colonized organism and causal organism coincided only in 26 (41.9%) of the 62 patients. Neither colonization nor the UTI was associated with graft or patient outcome.
Conclusion. Perioperative genitourinary colonization of common bacterial pathogens increases the risk of urinary tract infection after transplantation.
To cite this abstract in AMA style:
Han A, Choi C, Min S-I, Min S-K, Kim S, Park M, Ha J. Perioperative Bacterial Colonization and Postoperative Urinary Tract Infection in Kidney Transplant Recipients [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/perioperative-bacterial-colonization-and-postoperative-urinary-tract-infection-in-kidney-transplant-recipients/. Accessed May 13, 2025.« Back to 2015 American Transplant Congress