ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Performance of Updated Estimated Glomerular Filtration Rate Equations in Black Living Kidney Donor Candidates

J. Augustine, A. Liaqat, S. Arrigain, J. Schold, E. Poggio

Cleveland Clinic, Cleveland, OH

Meeting: 2022 American Transplant Congress

Abstract number: 491

Keywords: African-American, Glomerular filtration rate (GFR), Kidney transplantation, Living donor

Topic: Clinical Science » Kidney » 42 - Kidney Living Donor: Selection

Session Information

Session Name: Kidney Living Donor & Paired Exchange

Session Type: Rapid Fire Oral Abstract

Date: Tuesday, June 7, 2022

Session Time: 5:30pm-7:00pm

 Presentation Time: 5:40pm-5:50pm

Location: Hynes Room 302

*Purpose: New estimated glomerular filtration rate (eGFR) equations using serum creatinine (Cr) and/or cystatin C (CysC) have been derived to eliminate adjustment by perceived Black ancestry. We sought to analyze the performance of newer eGFR equations in Black living kidney donor (LD) candidates.

*Methods: Black LD candidates (n=64) who had measured iothalamate (i)GFR between 1/2015 and 10/2021 were included, and eGFR was calculated using race adjusted (Cr2009, Cr-CysC2012) and race unadjusted (Cr2021, Cr-CysC2021) CKD-EPI equations. Bias (eGFR-iGFR) and accuracy (percent within 30% of iGFR) were calculated.

*Results: Mean age at LD evaluation was 41±12 yrs, and 45% were male. Mean iGFR was 105±23 ml/min/1.73m2. Results are shown in the Table. CKD-EPICr2021 eGFR showed a greater negative bias, and underestimated iGFR to a level <80 ml/min/1.73m2 in 11% with iGFR ≥ 80. Alternatively, the CKD-EPICr-CysC2021 equation showed less bias and high accuracy in the absence of correction for Black ancestry. In donor candidates with iGFR ≥ 80 ml/min/1.73m2, none were estimated below 80 by the CKD-EPICr-CysC2021 equation.

*Conclusions: The CKD-EPICr2021 equation appears to underestimate true GFR in Black LD candidates, with the potential to exclude some for falsely low eGFR. Alternatively, the recently recalibrated CKD-EPICr-CysC2021 equation appears to perform well in Black LD candidates, without negative bias or underestimation.

Variable Iothalamate GFR

CKD-EPI

Cr2009

CKD-EPI

Cr-CysC2012

CKD-EPI

Cr2021

CKD-EPI

Cr-CysC2021

Mean±SD (ml/min/1.73m2) 105±23 106±20 111±17 95±17 107±15

Bias (median, [P25,P75])

(ml/min/1.73m2)

2.4

[-12,5,12.5]

8.0

[-6.8,18.0]

-9.0

[-22.8,-0.2]

5.0

[-10.8,13.4]

Accuracy (%)

79.7 89.1 85.9 89.1
% GFR < 80 ml/min/1.73m2 10.9 7.8 4.7 18.8 4.7

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Augustine J, Liaqat A, Arrigain S, Schold J, Poggio E. Performance of Updated Estimated Glomerular Filtration Rate Equations in Black Living Kidney Donor Candidates [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/performance-of-updated-estimated-glomerular-filtration-rate-equations-in-black-living-kidney-donor-candidates/. Accessed May 30, 2025.

« Back to 2022 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences