Date: Saturday, June 11, 2016
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Pancreas transplantation is the definitive treatment for diabetes mellitus (DM). The advantages of simultaneous kidney pancreas transplant in Latinos have been demonstrated previously, but there is still a lack of knowledge regarding racial disparity outcomes. In this study, we investigate the pre and post transplant risk factors contributing to allograft survival in the Latino population.
An institutional review of the database between 1999-2014 was conducted to determine pancreatic allograft survival in the Latino population. Medical records were reviewed for donor information, recipient data, and post transplant outcomes.
A total of 37 pancreas transplants were performed on Latino patients (35 simultaneous kidney pancreas, 1 pancreas alone, 1 pancreas after kidney). The median recipient age was 35 years, while the median donor age was 23 years. The median pancreas allograft survival was 7.04 years, with 5 resultant transplant pancreatectomies (4 thrombosed allografts, 1 small bowel necrosis) and 5 patient deaths. Two patients underwent pancreas re-transplantation. There were 8 biopsy-proven pancreas rejection episodes. Ten patients became insulin-dependent post transplant. Body mass index (BMI), Hgb A1C and C-peptide levels were in recipients requiring insulin post transplant to those that remained insulin free.
|Median Pre Transplant BMI||27||22||27|
|Median BMI at Last Follow Up||29.76||25.48||28.5|
|Median BMI Change Post Transplant||1.92||3.48||1.5|
|Median Pre Transplant HgbA1C||8.7||9.55||8.9|
|Median HgbA1C at Last Follow Up||5.6||8.55||6|
|Median Pre Transplant C peptide||1.2||0.1||1.1|
|Median C peptide at Last Follow Up||5.2||12.2||6.45|
There was an observed overall weight gain and increase in BMI post pancreas transplant in all Latino patients. Furthermore, patients who became insulin-dependent had a greater increase in their BMI, higher Hgb A1C and higher C-peptide level compared to their insulin free counterparts. The need for insulin post pancreas transplant may not be due to allograft failure, but the development of insulin resistance (type 2 DM) related to post transplant weight gain which may be more prominent in the Latino population.
CITATION INFORMATION: Fernandez H, McKenna G, Onaca N, Ruiz R. Pancreatic Allograft Failure in Latino Recipients: Diabetes Mellitus Type 2 Conversion? Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Fernandez H, McKenna G, Onaca N, Ruiz R. Pancreatic Allograft Failure in Latino Recipients: Diabetes Mellitus Type 2 Conversion? [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/pancreatic-allograft-failure-in-latino-recipients-diabetes-mellitus-type-2-conversion/. Accessed April 16, 2021.
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