Pancreatic Allograft Failure in Latino Recipients: Diabetes Mellitus Type 2 Conversion?
Baylor University Medical Center, Dallas, TX.
Meeting: 2016 American Transplant Congress
Abstract number: A55
Keywords: Pancreas transplantation
Session Information
Session Name: Poster Session A: Clinical Pancreas Transplantation and All Islet Cell Transplantation Topics
Session Type: Poster Session
Date: Saturday, June 11, 2016
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Introduction:
Pancreas transplantation is the definitive treatment for diabetes mellitus (DM). The advantages of simultaneous kidney pancreas transplant in Latinos have been demonstrated previously, but there is still a lack of knowledge regarding racial disparity outcomes. In this study, we investigate the pre and post transplant risk factors contributing to allograft survival in the Latino population.
Methods:
An institutional review of the database between 1999-2014 was conducted to determine pancreatic allograft survival in the Latino population. Medical records were reviewed for donor information, recipient data, and post transplant outcomes.
Results:
A total of 37 pancreas transplants were performed on Latino patients (35 simultaneous kidney pancreas, 1 pancreas alone, 1 pancreas after kidney). The median recipient age was 35 years, while the median donor age was 23 years. The median pancreas allograft survival was 7.04 years, with 5 resultant transplant pancreatectomies (4 thrombosed allografts, 1 small bowel necrosis) and 5 patient deaths. Two patients underwent pancreas re-transplantation. There were 8 biopsy-proven pancreas rejection episodes. Ten patients became insulin-dependent post transplant. Body mass index (BMI), Hgb A1C and C-peptide levels were in recipients requiring insulin post transplant to those that remained insulin free.
|
Insulin Free (n=27) |
Insulin Dependent (n=10) |
All Patients (n=37) |
|
| Median Pre Transplant BMI | 27 | 22 | 27 |
| Median BMI at Last Follow Up | 29.76 | 25.48 | 28.5 |
| Median BMI Change Post Transplant | 1.92 | 3.48 | 1.5 |
| Median Pre Transplant HgbA1C | 8.7 | 9.55 | 8.9 |
| Median HgbA1C at Last Follow Up | 5.6 | 8.55 | 6 |
| Median Pre Transplant C peptide | 1.2 | 0.1 | 1.1 |
| Median C peptide at Last Follow Up | 5.2 | 12.2 | 6.45 |
Conclusion:
There was an observed overall weight gain and increase in BMI post pancreas transplant in all Latino patients. Furthermore, patients who became insulin-dependent had a greater increase in their BMI, higher Hgb A1C and higher C-peptide level compared to their insulin free counterparts. The need for insulin post pancreas transplant may not be due to allograft failure, but the development of insulin resistance (type 2 DM) related to post transplant weight gain which may be more prominent in the Latino population.
CITATION INFORMATION: Fernandez H, McKenna G, Onaca N, Ruiz R. Pancreatic Allograft Failure in Latino Recipients: Diabetes Mellitus Type 2 Conversion? Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Fernandez H, McKenna G, Onaca N, Ruiz R. Pancreatic Allograft Failure in Latino Recipients: Diabetes Mellitus Type 2 Conversion? [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/pancreatic-allograft-failure-in-latino-recipients-diabetes-mellitus-type-2-conversion/. Accessed November 22, 2024.« Back to 2016 American Transplant Congress