Abstracts Archive - Page 913 of 1683 - ATC Abstracts

2018 American Transplant Congress
Effect of Direct-Acting Hepatitis C Treatment Regimens on Calcineurin Inhibitors in Liver and Kidney Transplant Patients
M. Laub, J. Byrns, M. Harris, C. Berg, S. Sanoff.
Duke University Hospital, Durham, NC.
Background: It has been suggested that treatment with direct-acting antivirals (DAA) for hepatitis C virus (HCV) may decrease calcineurin inhibitor (CNI) concentrations. The purpose of…
2018 American Transplant Congress
Outcomes of Antiviral Treatment (AVT) in Hepatitis C Virus (HCV) Liver Transplant (LT) Patients off Immunosuppression (IS) in Direct Acting Antivirals (DAA) Era
E. Agudelo,^1,2 I. Campos-Varela,³ N. Terrault.^1,2
¹Medicine, University of California San Francisco, San Francisco, CA; ²Surgery, University of California San Francisco, San Francisco, CA; ³Internal Medicine, Hospital of Santiago de Compostela, Santiago de Compostela, Spain.
Background: Clearance of HCV under AVT, including DAAs, has been associated with higher risk of rejection, possibly due to the changing immunological environment within the…
2018 American Transplant Congress
Treatment and Outcomes of Orthotopic Liver Transplant Patients Secondary to Hepatitis C Virus: A Single Center Experience
T. Chen,¹ M. Moaddab,¹ B. Pierce,¹ R. Ghobrial.²
¹Department of Pharmacy, Houston Methodist Hospital, Houston, TX; ²Department of Surgery, Houston Methodist Hospital, Houston, TX.
Background: Treatment of acute cellular rejection (ACR) in patients with orthotopic liver transplantation (OLT) secondary to hepatitis C virus (HCV) remains a major challenge due…
2018 American Transplant Congress
Hepatitis C Recurrence after Liver Transplant: A Comparison of Antibody Induction versus No Antibody Induction
S. Patel, J. Jin, E. Benedetti, P. West-Thielke.
University of Illinois Hospital and Health Sciences System, Chicago.
Background: Hepatitis C virus (HCV) recurrence after orthotopic liver transplant (OLT) is universal and exhibits accelerated progression to cirrhosis. Progression can be mitigated by new…
2018 American Transplant Congress
Enhancement of Muscle Regeneration and Function via Transplantation of Human Dystrophin Expressing Chimeric Cells as a Novel Myoblast Stem-Cell Based Therapy
M. Siemionow,¹ J. Cwykiel,¹ E. Marchese,¹ G. Rafidi,¹ K. Futoma,¹ A. Heydemann,² J. Garcia-Martinez,² E. Szilagyi.¹
¹Orthopaedics, University of Illinois at Chicago, Chicago; ²Physiology and Biophysics, University of Illinois at Chicago, Chicago.
PURPOSE: Allogeneic myogenic stem cell transplantation aims to restore muscle tissue after traumatic loss or to treat muscular dystrophies. Limited engraftment due to allogeneic rejection…
2018 American Transplant Congress
Exosomes from Umbilical Cord-Derived Mesenchymal Stem Cells on Hepatocytes Proliferation after Small-for-Size Liver Transplantation via RHO/ROCK Pathway
L. Chen, J. Zheng, J. Cai, J. Yao, K. Zeng, Y. Zhang, Y. Yang.
Department of Liver Transplantation, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Exosomes from umbilical cords-derived mesenchymal stem cells (UC-MSCs-Ex) have been recognized as their ability to promote tissue regeneration in many animal models. However, the in…
2018 American Transplant Congress
Mitochondrial Quality Control through PGC-1α in Syngenic Mouse Heart Transplant
A. Cherry,¹ K. Porter,¹ H. Suliman,¹ J. Wang,² M. Mulvihill,² A. Kirk.²
¹Anesthesiology, Duke University, Durham, NC; ²Surgery, Duke University, Durham, NC.
Intro: Impaired mitochondrial function plays a role in graft dysfunction after transplant, and recovery is facilitated by mitochondrial quality control (MQC). Two key elements of…
2018 American Transplant Congress
Extracellular Vesicles Derived from Huc-MSCs Alleviate Rat Hepatic Ischemia-Reperfusion Injury by Suppressing Oxidative Stress and Neutrophil Inflammatory Response
J. Yao,^1,2 J. Cai,^1,2 J. Zheng,^1,2 L. Chen,^1,2 Y. Zhang,^1,2 Y. Yang.^1,2
¹Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Guangzhou, Guangdong, China; ²Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education Institutes, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, .
Mesenchymal stem cells (MSCs) have been reported possessing therapeutic effects on immunoregulation, tissue repair and regeneration from bench to bedside. Extracellular vesicles (EVs) derived from…
2018 American Transplant Congress
Postoperative Renal Function Predicts Length of Stay for Incisional Hernia Repair after Liver Transplantation
J. Butler, D. O'Brien, J. Kays, C. Kubal, B. Ekser, J. Fridell, R. Mangus, J. Powelson.
Transplant Surgery, Indiana University, Indianapolis, IN.
Background: Incisional hernia repair (IHR) is the most frequently performed general surgery procedure after orthotopic liver transplantation (OLT). Although enhanced recovery protocols for general surgery…
2018 American Transplant Congress
The Grade of Pre-Transplant Portal Vein Thrombosis in Liver Transplant Recipients Impacts Graft and Patient Survival
M. Safwan, M. Sobolic, S. Nagai, R. Schilke, K. Collins, A. Yoshida, M. Abouljoud, M. Rizzari.
Henry Ford Transplant Institute, Henry Ford Health System, Detroit, MI.
Background: Portal vein thrombosis (PVT) in the pre-transplant (pretx) setting makes liver transplantation technically challenging and is also known to affect post transplant outcomes. Few…