Abstracts Archive - Page 908 of 1683 - ATC Abstracts

2018 American Transplant Congress
Determining the Utility of Protocol Biopsies in Kidney Transplant Recipients
J. Patel,¹ K. Heshmati,² A. Rogers,¹ R. Wali,² J. Jonsson,² C. Liu,² E. Emery,² D. Collins,² S. Karzai,² J. Piper.²
¹Virginia Commonwealth University, Falls Church; ²Inova Fairfax Hospital, Falls Church.
Protocol biopsies may allow for early detection and treatment of kidney transplant rejection or other correctable pathology, leading to improved graft survival. Unfortunately, biopsies may…
2018 American Transplant Congress
Results of UNOS Survey on Diagnosis, Treatment and Follow-Up Evaluation of Clinical and Sub-Clinical TCMR and ABMR in Kidney Transplant Recipients
P. Sood,¹ W. Cherikh,² A. Toll,² R. Mehta,¹ C. Puttarajappa,¹ S. Hariharan.¹
¹University of Pittsburgh Medical Center, Pittsburgh; ²UNOS, Richmond.
Management strategies for treatment of rejection post ktx vary among centers. Controlling minor degrees of inflammation can prevent chronic allograft scarring. To study the diverse…
2018 American Transplant Congress
Highly Correlative Whole-Tissue Gene/protein Signatures to Score FFPE Transplant Biopsies with Inflammation and Acute Rejection
T. Sigdel, M. Nguyen, D. Dobi, S-.C. Hsieh, J. Liberto, F. Vincenti, Z. Laszik, M. Sarwal.
Unversity of California San Francisco, San Francisco.
Background: We have previously reported the quantification of a common immune response module (CRM) of 11 genes to identify and score acute rejection (AR) across…
2018 American Transplant Congress
Diagnosis of Acute Renal Rejection Using Saliva Metabolome Analysis
H. Iwamoto,¹ M. Sugimoto,² O. Konnno,¹ Y. Kihara,¹ T. Yokoyama,¹ Y. Nakamura,¹ M. Sunamura,¹ T. Ueno.¹
¹Kidney Transplantation Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan; ²Health Promotion and Preemptive Medicine, Research and Development Center for Minimally Invasive and Preemptive Medicine, Tokyo Medical University, Hachioji, Japan; ³Department of Digestive Surgery and Transplantation Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan.
(Objective) Wide variety of biomarker discoveries have been conducted to realize low-invasive detection of rejection after renal transplantation. Metabolomics, an omics technology to enable simultaneous…
2018 American Transplant Congress
Belatacept-Refractory CD8⁺CD28^–CD38^hi Effector/Memory T Cells Are Targeted by mTOR Inhibition Leading to a Preferential Loss of CD40L
C. Castro Rojas,¹ A. Godarova,¹ A. Rike Shields,² R. Alloway,² M. Jordan,³ E. Woodle,² D. Hildeman.¹
¹Division of Immunobiology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH; ²Division of Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH; ³Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Research Foundation, Cincinnati, OH.
Calcineurin inhibitors (CNIs) and corticosteroids (CSS) have substantial untoward side effects, most notably nephrotoxicity. Consequently, the FDA approved belatacept for maintenance immunosuppression. We recently completed…
2018 American Transplant Congress
New SLK Allocation Policy May Impact Transplant Outcomes in Women
G. Cullaro,¹ R. Hirose,² J. Lai.¹
¹Medicine, University of California, San Francisco, San Francisco, CA; ²Transplant Surgery, University of California, San Francisco, San Francisco, CA.
Background: Previous SLK allocation was based on serum creatinine(Cr), a metric that disadvantaged women(W) relative to men(M). A SLK policy change utilizes eGFR, which accounts…
2018 American Transplant Congress
Liver Transplants from Older Donors Have Worse Outcomes in Elderly Recipients with Renal Dysfunction
R. Schilke,¹ M. Safwan,¹ S. Nagai,¹ M. Abouljoud,² A. Patel.¹
¹Transplant Institute, Henry Ford Health System, Detroit, MI; ²Nephrology, Henry Ford Health System, Detroit, MI.
Background: Most end stage liver disease patients suffer from concomitant renal insufficiency. We aimed to study influence of donor age on outcomes in elderly liver…
2018 American Transplant Congress
Comparing Outcomes between Induction Immunosuppressive Therapies in Simultaneous Liver/Kidney Transplantation
U. Gautam, T. Reichman, J. Yu, S. Koppu, D. Bandyopadhyay, M. Levy, G. Gupta, L. Kamal.
Virginia Commonwealth University, Richmond, VA.
Introduction: There is no data on the risks and benefits of induction immunosuppression in simultaneous liver/kidney transplant (SLKT) patients.Methods: We analyzed all SLKT performed between…
2018 American Transplant Congress
Liver Transplantation with or without Left Renal Vein Ligation: Comparative Study of 105 Cases
M. Perosa,¹ H. Noujaim,¹ J. Branez,¹ L. Mota,¹ B. Zeballos,¹ R. Santos,¹ A. Watanabe,² G. Ferreira,² A. Moraes,² A. Silvestre,³ G. Martinho,⁴ N. Siqueira,⁵ T. Genzini.¹
¹Abdominal Organ Transplantation, Leforte Hospital, Sao Paulo, Brazil; ²ICDF Hospital, Brasilia, Brazil; ³Medical School, Sao Camilo, Sao Paulo, Brazil; ⁴Medical School, Santa Casa, Sao Paulo, Brazil; ⁵Hospital das Clínicas, Rio Branco, Acre, Brazil.
The presence of large spontaneous splenorenal shunts (SSRS) is a risk factor for low portal flow and graft dysfunction after liver transplantation (LT). Left renal…
2018 American Transplant Congress
No Deleterious Effect from the Presence of Donor Specific Antibodies (DSA) or Positive Flow Cytometry Crossmatch (FCXM) on the Outcomes of Simultaneous Liver-Kidney (SLK) Transplant Recipients
H. Khamash, A. Kumar, B. Aqel, R. Heilman, A. Jaramillo, K. Reddy, A. Moss.
Mayo Clinic Arizona, Phoenix.
SLK transplant recipients have excellent outcomes that rival kidney alone recipients in terms of graft and patient survival and have better outcomes in terms of…