2018 American Transplant Congress
Early Sub-Clinical and Clinical TCMR Are Associated with Progressive Renal Allograft Dysfunction
Background: The clinical course and significance of early sub-clinical (SCR) and clinical TCMR (ACR) vs. no rejection (NR) is unclear. In this prospective study, we…2018 American Transplant Congress
Reduced Ratio of FoxP3/ RORγt Gene Expression, in Peripheral Blood, is Associated with Acute Allograft Rejection in Recipients with Kidney Transplantation
Introduction:FoxP3 has been well established as an indispensable protein that is required in the development and function of regulatory T cells. On the other hand,…2018 American Transplant Congress
Outcomes of Kidney Transplant Recipients with Early Allograft Inflammation: A Prospective Study
University of Pittsburgh Medical Center, Pittsburgh.
The impact of early allograft inflammation is unclear. We prospectively studied changes in renal function and histology in a cohort of patients who received a…2018 American Transplant Congress
Polymorphisms of Nucleotide Factor of Activated T Cells Cytoplasmic 2 and 4 and the Risk of Acute Rejection Following Kidney Transplantation
Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Background: Acute rejection (AR) is a common complication of kidney transplantation. Nuclear factors of activated T cells (NFATs) are transcription factors involved in the activation…2018 American Transplant Congress
Subclinical Borderline Rejection: More Than Meets the Eye?
UAB School of Medicine, Birmingham.
Purpose: Surveillance biopsies can detect subclinical T cell mediated rejection (SC-TCMR) or subclinical borderline rejection (SC-B-TCMR) in patients with normal/stable creatinine, but the impact on…2018 American Transplant Congress
Performance of Molecular Diagnostic Algorithms of T-Cell Mediated Kidney Rejection (TCMR) in Non-Transplant Biopsies with Interstitial Nephritis
DNA microarray based tools for the diagnosis of TCMR have been developed and are now being offered commercially. There is need to further evaluate the…2018 American Transplant Congress
Delayed Achievement of Therapeutic Tacrolimus Levels after Renal Transplantation is Not Associated with Increased Incidence of Early Acute Rejection: Single-Center Results
Division of Transplant Surgery, Department of Surgery, University of Washington, Seattle, WA.
Induction therapy followed by maintenance with a calcineurin inhibitor aims to minimize the incidence of early rejection and optimize the potential for allograft function. However…2018 American Transplant Congress
Long-Term Outcomes of Graft Function in Elderly Kidney Transplant Recipients
Henry Ford Transplant Institute, Detroit, MI.
Purpose: To compare and evaluate 5-year outcomes of graft function for younger (Y) versus elderly (E) kidney transplant recipients (KTR).Introduction: As the number of elderly…2018 American Transplant Congress
Multivariate Cox Proportional Hazards Model for Estimating Long-Term Risk of Aging Kidney Transplant Recipients
Henry Ford Transplant Institute, Detroit, MI.
Purpose: The growing number of elderly kidney transplant recipients (KTR) presents an opportunity to analyze and predict long-term outcomes and risk in this aging population.Methods:…2018 American Transplant Congress
Clinically Relevant Variation of Donor-Derived Cell-Free DNA during Longitudinal Surveillance of Renal Allografts
Purpose: Donor-derived cell-free DNA (dd-cfDNA) levels >1% are associated with active rejection in renal transplant recipients. This report defines the clinically relevant variation of dd-cfDNA…
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