Abstracts Archive - Page 897 of 1683 - ATC Abstracts

2018 American Transplant Congress
Urinary Microbiome Associated with Chronic Allograft Dysfunction in Kidney Transplants
A. Israni,^1,2 A. Muthusamy,² B. Wu,³ B. Guo,³ D. Knights,⁴ G. Al-Ghalith,⁴ J. Wu,¹ W. Oetting,⁵ D. Schladt,² R. Remmel,⁵ P. Jacobson,⁵ For DeKAF Genomics & GEN03 Investigators.¹
¹Medicine, Hennepin County Medical Center, University of Minnesota (UMN), Minneapolis; ²Minneapolis Medical Research Foundation, Mpls; ³Biostatistics, UMN, Mpls; ⁴Computer Science, UMN, Mpls; ⁵College of Pharmacy, UMN, Mpls.
Background: Microbiome dysbiosis can lead to poor outcomes after kidney transplant (tx) presumably due to immune dysregulation elicited by the microbiome. We hypothesize that chronic…
2018 American Transplant Congress
Etiologies and Long-Term Outcomes of Acute Kidney Injury in Older Kidney Transplant Recipients
R. Rodriguez, P. Amechi, V. Rao, D. Taber, M. Posadas Salas.
Medical University of South Carolina, Charleston, SC.
Older kidney transplant recipients face challenges of post-transplant complications related to frailty and comorbidity burden. They are particularly vulnerable to acute kidney injury (AKI) due…
2018 American Transplant Congress
Change in Estimated Glomerular Filtration Rate Pre and Post Development of Donor-Specific Antibodies after Kidney Transplantation
B. Ho,¹ S. Montag,^1,2 H. Bhagat,³ K. Atiemo,¹ A. Daud,¹ R. Kang,¹ L. Zhao,^1,2 J. Schwartz,³ D. Ladner.¹
¹Northwestern University Transplant and Outcomes Research Collaborative (NUTORC), Chicago; ²Dept of Preventive Medicine, Northwestern University, Chicago; ³Astellas Pharma Global Development, Inc., Northbrook.
Formation of de novo donor-specific antibodies (dnDSA) against human leukocyte antigens contributes to inferior kidney transplant (KT) outcomes. We assessed the effect of dnDSA on…
2018 American Transplant Congress
Metabolic Acidosis after Kidney Transplantation: Prevalence, Risk Factors and Graft Outcome in a French Cohort
F. Garo, I. Szwarc, G. Mourad, M. Le Quintrec, J-.E. Serre.
Nephrology, University Hospital of Montpellier, Montpellier, France.
Background: Metabolic acidosis (MA) lead to several complications in more advanced stages of chronic kidney diseases (CKD) and promotes CKD progression. Acidosis is a common…
2018 American Transplant Congress
Assessing Fibrosis Burden in Renal Allograft with Chronic Damage Using Functional Magnetic Resonance Imaging
J. Wen,¹ W. Wang,² X. Ni,¹ Y. Yu,³ J. Chen,¹ L. Zhang,³ Z. Liu.¹
¹Jinling Hospital, Nanjing University School of Medicine, National Clinical Research Center of Kidney Diseases, Nanjing, Jiangsu, China; ²Nanjing Medical University, Jinling Clinical Hospital, Nanjing, Jiangsu, China; ³Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, China.
Background: Renal allograft fibrosis burden is a strong prognosticator for chronic damage and can only be accurately measured through transplant biopsy at present. We hypothesized…
2018 American Transplant Congress
Association between Genetic Polymorphisms of Fc Gamma Receptor Genes (FcgR) and the Development of Donor Specific Antibodies (DSA) after Kidney Transplant
D. Min,¹ Y. Chang,² T. Shah.³
¹College of Pharmacy, Western University of Health Sciences, Pomona, CA; ²National Institute of Transplantation Foundation, Los Angeles, CA; ³Multi-Organ Transplant Center, St. Vincent Medical Center, Los Angeles, CA.
Background: Antibody mediated rejection (AMR) is one of the most important barriers to improve long-term kidney transplant outcomes. The presence of donor specific antibodies (DSA)…
2018 American Transplant Congress
Urinary Sulfate Excretion and Late Graft Failure in Renal Transplant Recipients
M. Said,¹ A. Post,¹ I. Minovic,¹ M. van Londen,¹ H. van Goor,² D. Postmus,³ M. Heiner-Fokkema,⁴ E. van den Berg,¹ A. Pasch,⁵ G. Navis,¹ S. Bakker.¹
¹Department of Internal Medicine, University Medical Center Groningen, Groningen, Netherlands; ²Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands; ³Department of Epidemiology, University of Groningen, Groningen, Netherlands; ⁴Department of Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands; ⁵Department of Biomedical Research, University of Bern, Bern, Switzerland.
BackgroundHydrogen sulfide (H2S), produced from the metabolism of dietary sulfur-containing amino acids, is allegedly a potential renoprotective compound. High 24h urinary excretion of pathway intermediate…
2018 American Transplant Congress
The Value of Serum Dilution on DSA Outcome Analysis in Renal Transplantation
W. Huang,¹ L. Rebellato,² K. Briley,² P. Bolin,² S. Kendrick,³ A. Maldonado,⁴ D. Leeser,² C. Haisch,² M. Everly.¹
¹Terasaki Research Institute, Los Angeles, CA; ²East Carolina University, Greenville, NC; ³Eastern Nephrology Associates, Greenville, NC; ⁴Vidant Medical Center, Greenville, NC.
Background: Recently, transplant centers have discussed the potential value of sera dilutions in assessment of donor specific anti-HLA antibodies (DSA). However, to date, no data…
2018 American Transplant Congress
Long-Term Outcomes of Primary Kidney Transplant from Expanded Criteria Maastricht Category 3 DCD Donors: A Single-Centre Observational Study
E. Favi,¹ C. Puliatti,² S. Iesari,³ M. Ferraresso,¹ R. Cacciola.²
¹Kidney Transplantation, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy; ²Kidney Transplantation, The Royal London Hospital, London, United Kingdom; ³Kidney Transplantation, University of L'Aquila, L'Aquila, Italy.
Background. Kidney transplants (KTx) from standard (STD) DCD donors have higher rates of primary non function (PNF) and delayed graft function (DGF) than DBD but…
2018 American Transplant Congress
Angiotensin II Type 1 Receptor Antibodies as Markers of Post Transplant Focal Segmental Glomerulosclerosis and Proteinuria
A. Aala, M. Philogene, N. Alachkar.
Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD.
Background:Angiotensin II type 1 receptor (AT1R) is highly expressed on the endothelial cells and podocytes, which play an essential role in the maintenance of vascular…