Abstracts Archive - Page 818 of 1683 - ATC Abstracts

2018 American Transplant Congress
Metabolic Regulation of Neuropeptides Induces Weight Loss and is Linked to Prolongation of Allograft Survival
M. Quante,^1,2 T. Heinbokel,¹ K. Minami,¹ Y. Nian,¹ A. Elkhal,¹ S. Tullius.¹
¹Transplant Surgery Research Lab, Brigham and Women's Hospital, Boston, MA; ²Department of General, Visceral and Transplant Surgery, Tuebingen Unversity Hospital, Tuebingen, Germany.
Obesity has become a common comorbidity among transplant recipients that is linked to inferior transplant outcome through far-reaching effects on metabolism, inflammation and immunity. Increasingly,…
2018 American Transplant Congress
Application of RNA-Seq Derived Diagnostic Algorithms of T-Cell Mediated Kidney Rejection (TCMR) to DNA Microarray-Based Gene Expression Datasets
Z. Wang,¹ L. Pan,² Z. Lyu,² P. Liu,³ G. Tseng,³ P. Randhawa.¹
¹Department of Pathology, The Thomas E Starzl Transplantation Institute, University of Pittsburgh, School of Medicine, Pittsburgh, PA; ²Department of Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China; ³Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Recent years have seen the development of DNA microarray based tools for the diagnosis of TCMR using fresh frozen tissue. This study has accomplished the…
2018 American Transplant Congress
Thymic Irradiation as a Maneuver for Repertoire Exchange in Costimulatory-Blockade-Based Immunotherapy
M. Mulvihill,¹ B. Ezekian,¹ Q. Gao,¹ K. Samy,¹ R. Davis,¹ F. Leopardi,¹ W. Giles,² F-.F. Yin,² C. Willett,² B. Collins,¹ A. Kirk.¹
¹Department of Surgery, Duke University, Durham, NC; ²Department of Radiation Oncology, Duke University, Durham, NC.
Background All successful, prospective clinical tolerance-induction strategies have employed thymic irradiation to achieve chimerism. However, evidence suggests durable chimerism is not required to attain tolerance.…
2018 American Transplant Congress
p40 Homodimer Induced Proliferation of Endogenous Donor-Reactive Memory CD8 T Cells within High Risk Allografts Requires Memory CD8 T Cell Expression of CD122
H. Tsuda, A. Valujskikh, R. Fairchild.
Immunology, Cleveland Clinic, Cleveland, OH.
Increasing the duration of cold ischemic storage (CIS) from 0.5 to 8 hrs prior to transplant induces the increased proliferation of endogenous donor-reactive CD4 and…
2018 American Transplant Congress
Intensified Immunosuppression Improves Early Renal Allograft Function after Transplantation in a Porcine Model with Extended Asystolic Warm Ischemic Time
M. Xu,¹ X. Wang,¹ S. Garcia-Aroz,¹ B. Banan,¹ B. Rabe,¹ Z. Zhang,¹ J. Jia,¹ G. Upadhya,¹ P. Manning,² J. Gaut,³ Y. Lin,¹ W. Chapman.¹
¹Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St. Louis, MO; ²Arch Oncology, St. Louis, MO; ³Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
PURPOSE: Extensive ischemia-reperfusion injury significantly increases the immunogenicity of renal allograft which may be associated with increased risk of acute rejection (AR). This study investigated…
2018 American Transplant Congress
Comparative Analysis of Alloantigen-Stimulated Gene Expression in HIV(+) Liver Transplant Rejectors versus Non-Rejectors
S. Chu, K. Lee, C. Ward, P. Stock, Q. Tang.
Surgery, University of California, San Francisco, San Francisco, CA.
In a multi-center, prospective trial of solid-organ transplantation in persons with HIV, recipients had a 2-3x increased rejection rate when compared to historical data on…
2018 American Transplant Congress
Regulation of Indoleamine 2,3-Dioxygenase in Porcine Kidney Transplants
Y. Wang,¹ X. Fang,¹ D. Kleven,¹ C. Ho,² S. Nahman,^1,3 T. Merchen.¹
¹Augusta University, Augusta, GA; ²Gift of Life Michigan, Ann Arbor, MI; ³Norwood VAMC, Augusta, GA.
Indoleamine 2,3-dioxygenase (IDO) is an endogenous immunosuppressant exerting its effects through tryptophan depletion and kynurenine generation. Kynurenine 3-monooxygenase (KMO) is a downstream enzyme from IDO…
2018 American Transplant Congress
Melatonin Prolongs Heart Allograft Survival by Induction of Foxp3+ Regulatory T Cells
L. Liu, Q. Su, Y. Xiong, Z. Bi, H. Huang, Y. Peng, C. Wang.
The First Affiliated Hospital of Sun Yet-sen University, Guangzhou, China.
Objective: This study was aimed to investigate the effect of melatonin on heart allograft survival and explore the underlying mechanism. Methods and Results: Balb/c and…
2018 American Transplant Congress
Defining T Cell Subsets Involved in Rejection of Vascularized Composite Allografts
G. Furtmueller,¹ V. Malek,¹ B. Oh,¹ S. Reddy,¹ M. Iglesias,¹ G. Raimondi,¹ G. Brandacher, D. Cooney.
¹Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore; ²Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore.
BackgroundVascularized Composite Allotransplantation (VCA) is a clinically feasible therapeutic option for complex tissue defects. The highly immunogenic skin component of VCA represents a therapeutic challenge…
2018 American Transplant Congress
Improved Mouse Renal Transplantation Model Mimicking Clinical Antibody Mediated Rejection
D. Zhao,¹ T. Liao,¹ S. Li,¹ J. Zhou,² F. Han,¹ Y. Dong,³ Q. Sun.¹
¹Organ Transplantation Institution, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; ²Department of Pathology, Third Affiliated Hospital of Sun Yat-sen University, Guanghzou, Guangdong, China; ³Department of Pathology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Antibody mediated rejection (AMR) is main barrier to long term renal graft survival and mouse model is important to understand the mechanisms of AMR and…