Abstracts Archive - Page 813 of 1683 - ATC Abstracts

2018 American Transplant Congress
IL-10 Requirement in In Vitro Expanded Breg-Mediated Allograft Tolerance is Tissue Specific
C. Dai, K. Lee, L. Kojima, K. Deng, S. Kimura, C. Rickert, H. Yeh, J. Markmann.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
Introduction:Regulatory B cells (Bregs) have shown several multiple mechanisms of suppression, including Treg induction and IL-10 production. Consistent with work of other groups on Breg…
2018 American Transplant Congress
A Novel Conditioning Approach to Establish Chimerism Using Manipulation of JAK-STAT Pathways
H. Xu, A. Merchak, L. Kahn, A. Chhabra, Y. Wen, Y. Huang, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Hematopoietic chimerism establishes donor-specific tolerance to solid organ allografts. Targeting recipient immune cells (T, NK cells and macrophages) can effectively reduce the dose of total…
2018 American Transplant Congress
Characterization of Renal Allograft Tolerance Induction via Transient Mixed Chimerism in Non-Human Primates
H. Sasaki,¹ C. Thaiss,¹ T. Oura,¹ A. Rosales,² R. Smith,² R. Colvin,² B. Cosimi,¹ T. Kawai.¹
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston; ²Pathology, Massachusetts General Hospital, Boston.
Background: We have previously reported long-term renal allograft tolerance after induction of transient mixed chimerism in non-human primates. However, some recipients developed late onset chronic…
2018 American Transplant Congress
Human CD8⁺CD28^– Ts Cells Expanded by Common Gamma Chain (γc) Cytokines Keep Steady Allospecific Suppressive Capacity In Vivo
G. Liu,¹ F. Feng,¹ P. Zhu,¹ J. Liu,² Y. Liu,¹ Y. Yu.²
¹Department of Immunology, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong, China; ²Department of Urology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
Background: CD8+CD28- T suppressor (Ts) cells were recently reported to play a critical role in transplant tolerance, harnessing the potential for clinical use in transplantation.…
2018 American Transplant Congress
Type-1 Interferon Impairs the Immunoregulatory Activity of IL-10: Understanding the Mechanisms of Abrogation of Transplant Tolerance
M. Iglesias, A. Arun, M. Chicco, B. Lam, V. Ivanova, W. Lee, G. Brandacher, G. Raimondi.
Plastic Surgery, Johns Hopkins UIniversity, Baltimore, MD.
A growing body of evidence shows that induction of long term transplant survival by costimulation blockade (CoB) regimens is impaired by inflammatory responses (e.g. engagement…
2018 American Transplant Congress
Tomotherapy and Donor Hematopoietic Cells for Tolerance to Kidney Transplants in Rhesus Macaques
D. Kaufman,¹ L. Haynes,¹ P. Hematti,¹ W. Burlingham,¹ L. Forest,² J. Post,¹ R. Redfield,¹ L. Fernandez,¹ A. D'Alessandro,¹ J. Haynes,¹ K. Jensen,³ S. Strober.³
¹Surgery, University of Wisconsin School of Medicine, Madison, WI; ²Surgical Sciences, University of Wisconsin School of Vet Med, Madison, WI; ³Medicine, Stanford University Medical School, Palo Alto, CA.
The goal of this project was to develop a tolerance induction protocol for MHC 1-haplotype mismatched kidney transplants (txs) in a rhesus macaque model. The…
2018 American Transplant Congress
Achieving Allograft Tolerance through Antigen-Specific Regulatory B Cells
C. Rickert,^1,2 S. Kimura,^1,2 L. Kojima,¹ K. Lee,¹ M. Aburawi,¹ F. Fontan,¹ K. Deng,¹ H. Yeh,^1,2 J. Markmann.^1,2
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Boston, MA.
IntroductionA complete understanding of the role of antigen-specificity in the development of B cell mediated allograft tolerance has remained elusive. Previous work in our lab…
2018 American Transplant Congress
The Regulatory Role of Plasma Cells (as Bregs) is Counterbalanced by a NOVEL Inflammatory Role in Murine Transplant and Autoimmune Models
Z. Song,^1,2 Y. Zhou,² Q. Ding,¹ D. Rothstein.¹
¹Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh; ²School of Medicine, Tsinghua University, Beijing, China.
Plasma Cells (PCs; B220lowCD138hiBlimp1+Ig+) in LN and spleen were shown to be the major source of B cell lineage IL-10, and absence of PCs worsens…
2018 American Transplant Congress
LAG-3 Deletion Upregulates Memory in a Dendritic Cell-Dependent Process
S. Gibney,¹ M. Efre,¹ T. Ashry,¹ C. Yang,¹ T. O'Shea,^1,2 R. White,² P. Russell,¹ J. Madsen,¹ R. Colvin,² A. Alessandrini.^1,2
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA.
Introduction. Cardiac transplantation is critical for management of severe heart failure, but cardiac allografts frequently undergo chronic T-cell-mediated allograft rejection. Our research demonstrates that Lymphocyte…
2018 American Transplant Congress
Myeloid Derived Suppressor Cells Are Induced after Transplantation and Home to the Transplanted Kidney
Y. Lee, E. Davila, J. Bromberg, J. Scalea.
Surgery and Immunology, University of Maryland, Baltimore, MD.
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are a naturally occurring, heterogeneous population of highly immunosuppressive cells which expand in response to inflammatory conditions such as cancer.…