Abstracts Archive - Page 780 of 1683 - ATC Abstracts

2018 American Transplant Congress
TGR5-Mediated AMPK/mTOR Signaling Regulates Macrophage Migration and Polarization in Liver Ischemia Reperfusion
S. Zhou, H. Zhou, R. Liu, F. Zhang, X. Wang, L. Lu.
Liver Transplantation Center, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Background: Although the plasma membrane-bound G protein–coupled bile acid receptor (TGR5) exerts protective roles in various inflammatory diseases, little is known about the effects and…
2018 American Transplant Congress
In Vivo Allograft Exposure to Mitochondrial DAMPs Prior to Organ Procurement Increases Graft Rejection in Mice
L. Lin, J. Wang, L. Cendales, A. Kirk, T. Brennan.
Surgery, Duke University, Durham, NC.
Mitochondria released in the setting of tissue injury are a source of damage associated molecular patterns (DAMPs) that initiate innate immune responses. We hypothesized that…
2018 American Transplant Congress
Double Deficiency of Gelatinase-A and Gelatinase-B Does Not Protect against Hepatic Ischemia Reperfusion Injury
S. Duarte, P. Matian, S. Ma, R. Busuttil, A. Coito.
Dumont-UCLA Transplant Center, Los Angeles.
Gelatinases, consisting of gelatinase A (MMP-2; 72 KDa) and gelatinase B (MMP-9; 92KDa), are a subgroup of matrix metalloproteinases (MMPs) with key roles in a…
2018 American Transplant Congress
Cardiac Grafts from Insulin Resistant Donors Trigger a Heightened Immune Response via Excessive Induction of Autophagy
S. Cai,¹ J. Miao,² A. Chandraker.¹
¹Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA; ²Division of Endocrinology, Boston Children's Hospital, Boston, MA.
Background Heart transplantation remains the treatment of choice for many patients with medically refractory heart failure. The use of organs from patients with insulin resistant…
2018 American Transplant Congress
Soluble Fibrinogen-Like Protein 2 Regulates Myeloid-Derived Suppressor Cells Differentiation and Enhances Its Immunosuppressive Function of in Allograft Immunity
C. Yang, T. Zhu.
Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important…
2018 American Transplant Congress
In Vivo and In Vitro PPAR-y Activation Decreases M1-Macrophage Polarization and Improves Liver Ischemia Reperfusion Injury
I. Linares,¹ A. Bartczak,¹ K. Farrokhi,¹ D. Kollmann,¹ M. Kaths,¹ M. Hamar,¹ P. Urbanellis,¹ S. Ganesh,¹ O. Adeyi,² P. Yip,³ M. Selzner,¹ N. Selzner.¹
¹Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada; ²Department of Pathology, Toronto General Hospital, Toronto, ON, Canada; ³Laboratory of Medicine and Pathobiology, Toronto General Hospital, Toronto, ON, Canada.
Background:M1-Macrophage polarization has been studied as a potential target to decrease inflammatory response in sepsis and inflammation-related diseases. Its role in the setting of inflammatory…
2018 American Transplant Congress
Endothelial Progenitor Cell-Derived Extracellular Vesicles Inhibit Kidney Ischemia-Reperfusion Injury through the Transfer of Specific microRNA and mRNA Coding for the Complement Inhibitors CD55, CD59, Factor H and for the Transcription Factor NRF2: Relevance for Delayed Kidney Graft Function
V. Cantaluppi,¹ D. Medica,¹ S. Dellepiane,¹ G. Merlotti,¹ A. Airoldi,¹ M. Quaglia,¹ G. Castellano,² L. Gesualdo,² G. Camussi.³
¹Nephrology and Kidney Transplantation Unit, University of Piemonte Orientale (UPO), Novara, Italy; ²Nephrology, Dialysis and Kidney Transplantation Unit, University of Bari, Bari, Italy; ³Department of Medical Sciences, University of Torino, Torino, Italy.
Complement activation and oxidative cell damage are hallmarks of delayed kidney graft function (DGF) due to ischemia-reperfusion injury (IRI). Endothelial progenitor cells (EPC) protect from…
2018 American Transplant Congress
Ischemic Preconditioning Ameliorates Renal Ischemia-Reperfusion Injury in Mice via Heme Oxygenase-1-Mediated Autophagy
J. Hwang,² H. Choi,¹ M. Kim,² K. Jun,² K. Kown,² S. Park,² J. Kim,² I. Moon.²
¹Clinical Research, Daejeon St. Mary's Hospital, Daejeon, Korea; ²Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Recent data from animal experiments and clinical trials indicate that ischemic preconditioning (IPC) confers protection from renal ischemia-reperfusion (I/R) injury. Nevertheless, the underlying mechanisms for…
2018 American Transplant Congress
NK Cells with a Lung-Resident Phenotype Represent the Most Prominent Donor Passenger Leukocyte Subset after Clinical Lung Transplantation
C. Falk,¹ R. BellmasSanz,¹ B. Wiegmann,² A-.M. Hitz,¹ K. Bläsing,¹ C. Neudörfl,¹ I. Tudorache,² C. Kühn,² M. Avsar,² A. Haverich,² G. Warnecke.²
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
ObjectivesDonor passenger leukocytes in peripheral blood of recipients after lung transplantation have been described long time ago. However, kinetics, distribution of T vs. NK cells,…
2018 American Transplant Congress
Inhibition of Neutrophil Recruitment and Activation Protects Airway Epithelium after Transplantation
R. Zhang,¹ H. Fang,¹ Q. Chen,² J. Ochando,³ Y. Ding,¹ J. Xu.¹
¹Department of Immunology, Capital Medical University, Beijing, China; ²Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; ³Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Background: Obliterative bronchiolitis (OB) is the major obstacle limiting long-term allograft survival of lung transplantation. Airway epithelium is the primary target in obliterative airway diseases.…