Abstracts Archive - Page 779 of 1683 - ATC Abstracts

2018 American Transplant Congress
Ex Vivo Lung Perfusion Using the Portable OCS Maintains Endothelial Integrity in the Context of Reduced Severe PGD Rates
B. Wiegmann,¹ R. BellmasSanz,² C. Neudörfl,² C. Kühn,¹ I. Tudorache,¹ M. Avsar,¹ A. Haverich,¹ G. Warnecke,¹ C. Falk.²
¹Department of Cardiothoracic, Transplantation, Vascular Surgery, Hannover Medical School, Hannover, Germany; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
PurposeThe INSPIRE trial revealed significant reduction of PGD grade 3, i.e. less ischemia reperfusion injury (IRI) using the Organ Care System (OCS) compared to controls…
2018 American Transplant Congress
Rictor mTORC2 Signaling Protects Ischemic Liver Injury by Targeting Both Liver Parenchymal and Non-Parenchymal Cells
H. Zhou,¹ Z. Rao,¹ R. Liu,¹ S. Zhou,¹ J. Rao,¹ J. Gu,¹ H. Lu,¹ Y. Xia,¹ X. Wang,¹ Y. Zhai,² L. Lu.¹
¹First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²David Geffen School of Medicine at University of California-Los Angeles, Los Angeles.
Background and Aims:Mammalian target of rapamycin (mTOR) signaling controls many essential cellular functions. However, the role and its underlying mechanism of Rictor/mTOR complex 2 (mTORC2)…
2018 American Transplant Congress
C3a Receptor Regulates the CD8 T-Cell Alloresponse via Intrinsic and Extrinsic Mechanisms
J. Horwitz, D. Mathern, P. Heeger.
Icahn School of Medicine at Mount Sinai, NY, NY.
The role of complement in solid organ transplantation continues to evolve with our enhanced understanding of complement's regulation of the alloresponse. Prior work has shown…
2018 American Transplant Congress
Recipient Conditioning Results in IL-33 Support of Potent Th1 Alloimmune Responses after CD4⁺ T Cells Upregulate ST2 during Lymphopenia Induced Proliferation
G. Dwyer,¹ L. Mathews,¹ A. Lucas,¹ B. Blazar,² H. Turnquist.¹
¹Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; ²Department of Pediatrics, University of Minnesota, Minneapolis, MN.
Purpose: IL-33 is typically associated with support of Th2 and Treg responses. Yet, recipient conditioning before allogeneic hematopoietic cell transplantation (alloHCT) releases IL-33 to promote…
2018 American Transplant Congress
Peptides Encoded by EBV Latent Cycle Proteins Affect NK Cell Reactivity
B. Mbiribindi, C. Romero Moreno, C. Esquivel, O. Martinez, S. Krams.
Department of Surgery, Stanford University School of Medicine, Stanford, CA.
Introduction: Epstein–Barr virus (EBV) infects more than 90% of adults worldwide and is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). Although EBV infection…
2018 American Transplant Congress
Neuropeptide PACAP Protects Hepatocyte against Liver Ischemia/Reperfusion Injury by Promoting Yes-Associated Protein (YAP) Function
Z. Xue, Y. Liu, C. Zhang, R. Busuttil, J. Kupiec-Weglinski, H. Ji.
Dept of Surgery, The DumontUCLA Transplant Center, Los Angeles, CA.
Background: Previously we have demonstrated that neuropeptide pituitary adenylate cyclase-activating polypeptides (PACAP) suppressed local inflammation, and protected liver against IRI by innervating the liver and…
2018 American Transplant Congress
Leukocytes from Recipients with Severe Primary Graft Dysfunction after Lung Transplant Adoptively Transfer Alloreactivity to Vessel Grafts Trans Vivo
A-.K. Knoefel,¹ T. Siemeni,¹ N. Madrahimov,¹ W. Sommer,¹ M. Avsar,¹ L. Ahrens,¹ I. Tudorache,¹ A. Haverich,¹ C. Falk,² G. Warnecke.¹
¹HTTG, MHH, Hannover, Germany; ²Transplantimmunology, MHH, Hannover, Germany.
Introduction: Primary graft dysfunction (PGD) is the main cause of early mortality after lung transplantation (LTx). Multiple mechanisms have been described, but the link between…
2018 American Transplant Congress
Hyperglycemia Aggravates Hepatic Ischemia and Reperfusion Injury by Inhibiting Liver Resident Macrophage M2 Polarization via C/EBP-Homologous Protein-Mediated Endoplasmic Reticulum Stress
Z. Rao, J. Sun, X. Pan, Z. Chen, H. Sun, P. Zhang, M. Gao, Z. Ding, C. Liu.
Anesthesiology, First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Background:Aggravated liver ischemia and reperfusion (IR) injury has been observed in hyperglycemic hosts, but its underlying mechanism remains undefined. The aim of the study was…
2018 American Transplant Congress
Gr1^– Macrophages Play Critical Roles in Liver Inflammation Resolution after IRI via Efferocytosis
M. Ni,^1,2 H. Wang,^1,2 R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiansu, China.
Inflammation resolution is an integral part of liver ischemia reperfusion injury (IRI), which affects not only the severity of tissue damage, but more importantly its…
2018 American Transplant Congress
CCAAT-Enhancer-Binding Protein Homologous Protein Promotes Liver Ischemia and Reperfusion Injury by Inhibiting Beclin-1-Mediated Autophagy in Hepatocytes
H. Zhou,¹ Z. Rao,¹ Y. Xia,¹ R. Liu,¹ S. Zhou,¹ X. Wang,¹ Y. Zhai,¹ L. Lu.¹
¹First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²David Geffen School of Medicine at University of California-Los Angeles, Los Angeles.
Background and Aims:Critical role of endoplasmic reticulum (ER) stress has been found in ischemia and reperfusion(IR) injury models. However, the role of CCAAT-Enhancer-Binding Protein Homologous…