Abstracts Archive - Page 777 of 1683 - ATC Abstracts

2018 American Transplant Congress
Ischemia Reperfusion Injury Significantly Differs between Lung vs. Heart Transplantation with Respect to Lead Cytokines and Correlation to Clinical Outcome
B. Wiegmann,¹ N. Ledwoch,² J. ISke,² C. Neudörfl,² I. Tudorache,¹ C. Kühn,¹ T. Kaufeld,¹ F. Ius,¹ S. Rojas,¹ M. Avsar,¹ A. Haverich,¹ G. Warnwcke,¹ C. Falk.¹
¹Department of Cardiothoracic Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
ObjectivesIschemia reperfusion injury (IRI) is known to impair early graft function after lung (LTx) or heart (HTx) transplantation. We have previously characterized IRI in lungs…
2018 American Transplant Congress
Isolation and Profiling of miRNAs from Formalin Fixed Paraffin Embedded Endomyocardial Tissues from Human Heart Transplant Recipients
R. Nog,^1,2 C. Gupta,^1,2 J. Fallon,^1,2 J. Panza,^1,2 N. Haque.²
¹Westchester Medical Center, Valhalla, NY; ²New York Medical College, Valhalla, NY.
Allograft rejection is a common complication post heart transplant (HTx) and can be confirmed by endomyocardial biopsy (EBx) only. There is however an increasing need…
2018 American Transplant Congress
AT1R Antibody Analysis: High Proportion of Non-Specific Reactivity?
A. Halpin,^1,3,4,5 S. Abou-Zeki,³ I. Larsen,^1,4 P. Campbell,^2,3,4,5 S. Urschel,^1,4,5 L. West.^1,3,4,5
¹Dept of Pediatrics, U of Alberta, Edmonton, Canada; ²Dept of Medicine, U of Alberta, Edmonton, Canada; ³Dept of Lab Medicine & Pathology, U of Alberta, Edmonton, Canada; ⁴ATI, , Canada; ⁵CNTRP, , Canada.
INTRODUCTION:The angiotensin II type 1 receptor (AT1R) is expressed on vascular endothelium. AT1R antibodies (Ab) have been studied to examine their relevance in renal and…
2018 American Transplant Congress
Non-Invasive Imaging Modalities for Immune Monitoring of Vascularized Composite Allografts Using a Translational Large Animal Model
J. Etra,¹ K. Cilwa,² G. Furtmueller,¹ A. Leto Barone,¹ K. Kolegraff,¹ E. Elster,¹ W. Lee,¹ G. Brandacher.¹
¹Department of Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ²Naval Medical Research Center, Silver Springs, MD; ³Department of Surgery, Uniformed Services, University of Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD.
PurposeImmunological complications and skin rejection remains an obstacle in broadening the applicability of vascularized composite allotransplantation (VCA). Currently, diagnosis of rejection relies on skin biopsies…
2018 American Transplant Congress
Stress-Related Exosomal MicroRNA Biomarkers Released by Human Islets during Transplantation
P. Saravanan,¹ P. Nguyen,¹ G. Yoshimatsu,¹ C. Chang,¹ C. Darden,¹ R. Bhattacharjee,¹ X. Wang,¹ J. Gu,¹ M. Lawrence,¹ B. Naziruddin.²
¹Baylor Scott & White Research Institute, Dallas; ²Baylor Simmons Transplant Institute, Dallas.
Purpose: Pancreatic islets release noncoding microRNAs (miRNAs) upon damage and stress during islet transplant procedures. In this study, we sought to identify miRNAs released by…
2018 American Transplant Congress
Sensing T Cell Killing Activity with Granzyme B Activity Probes
Q. Mac,¹ D. Mathews,² J. Kahla,¹ C. Stoffers,¹ O. Delmas,¹ B. Holt,¹ A. Adams,² G. Kwong.¹
¹Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; ²Department of Surgery, Emory University School of Medicine, Atlanta, GA.
Purpose: We developed activity-based probes that sense Granzyme B (GzmB) activity during alloreactive T cell killing of donor cellsMethods: FITC-labelled GzmB substrate (IEFDSG) was synthesized…
2018 American Transplant Congress
The Impact of Childhood Solid Organ Transplantation on B-Cell Maturation
L. Ionescu,¹ T. Blydt-Hansen,² B. Foster,⁷ S. Mital,³ L. Hamiwka,⁵ U. Allan,³ V. Phan,⁴ P. Birk,⁶ C. Morgan,¹ S. Urschel.¹
¹U of Alberta, Edmonton, Canada; ²U of BC, Vancouver, Canada; ³Hospital for Sick Children, Toronto, Canada; ⁴U de Montreal, Montreal, Canada; ⁵U of Calgary, Calgary, Canada; ⁶U of Manitoba, Winnipeg, Canada; ⁷McGill University, Montreal, Canada.
Background:The developing immune system of childhood promotes better graft acceptance and longevity but also higher risk for infections and post-transplant (Tx) lymphoproliferative disorders. This may…
2018 American Transplant Congress
Brain Death Conditions Intensify Inflammation and Impair Metabolic Gene Expression
L. Zitur, P. Chlebeck, S. Odorico, T. Zens, J. Danobeitia, M. Eerhart, J. Reyes, A. D'Alessandro, K. Brunner, S. Capuano, L. Fernandez.
University of Wisconsin, Madison.
Rationale: Inflammation observed in Brain Death (BD) donors is linked to reduced graft function and survival compared to living donors (LD). Detailed analyses of non-human…
2018 American Transplant Congress
Different Expression Patterns of Exosomal miRNAs under Cyclosporin A and Rapamycin Treatment in Distinct Aggressiveness Colorectal Carcinomas
V. Tubita,¹ M. Ramírez-Bajo,¹ J. Lozano,² D. Moya-Rull,¹ J. Rovira,³ J. Campistol,^4,5,6 F. Diekmann,^1,4,5,6 I. Revuelta.^1,4,5,6
¹Experimental Laboratory of Nefrology and Kidney Transplant (LENIT). Biomedical Research Clinic Foundation (FCRB), Barcelona, Spain; ²Bioinformatics Platform, CIBEREHD, Barcelona, Spain; ³Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; ⁴Renal Transplant Unit. Department of Nephrology and Kidney Transplant. Hospital Clinic, Barcelona, Spain; ⁵REDinREN, Madrid, Spain; ⁶Barcelona University, Barcelona, Spain.
The aggressiveness of colorectal cancer (CRC) in kidney transplantation is much more significant than the increase in its incidence compared with the general population. The…
2018 American Transplant Congress
Tacrolimus Exposure in Human Proximal Tubule Cells Results in Differentially Increased CTGF Expression in Relation to Pharmacogenetic Variants of CYP3A5 and ABCB1
N. Knops,¹ Y. Ramazani,² B. Van den Heuvel,² R. Goldschmeding,³ T. Nguyen,³ E. Levtchenko,¹ D. Kuypers.⁴
¹Paediatric Nephrology and Solid Organ Transplantation, University Hospitals Leuven, Leuven, Belgium; ²Laboratory of Paediatrics, KU Leuven, Leuven, Belgium; ³Pathology, University Medical Center Utrecht, Utrecht, Netherlands; ⁴Nephrology, University Hospitals Leuven, Leuven, Belgium.
AIM: Clinical studies have demonstrated the importance of genetic variation for tacrolimus disposition and suggested a role in the development of renal fibrosis associated with…