Abstracts Archive - Page 70 of 1683 - ATC Abstracts

2022 American Transplant Congress
PSGL-1-mTOR-TIM3 Signaling in a Murine Model of Hindlimb Transplantation
K. Kadono¹, F. Messner², J. He², Y. Guo², B. Oh², G. Brandacher², J. Kupiec-Weglinski¹
¹UCLA Medical Center, Los Angeles, CA, ²Johns Hopkins UJohns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Peri-transplant tissue damage driven by innate-adaptive immune cascades resulting from ischemia-reperfusion injury (IRI) is a major concern in vascularized composite allotransplantation (VCA). Here, we…
2022 American Transplant Congress
De Novo DSA in the Setting of Stable Allograft Function is a Benign Finding
R. J. Knight, E. A. Graviss, D. T. Nguyen, T. N. Eagar, S. G. Yi, H. Podder, M. Hobeika, R. McMillan, A. O. Gaber
Houston Methodist Hospital, Houston, TX
*Purpose: We sought to determine the long-term outcome of renal allografts that developed de novo DSA (dnDSA) in the setting of stable renal function.*Methods: A…
2022 American Transplant Congress
Tissue Engineering Scaffolds for Minimally Invasive Immunosurveillance of Acute Cellular Graft Rejection
R. R. Urie¹, D. Farris², A. Morris¹, E. Lombard¹, J. Z. Li³, D. Goldstein², L. Shea¹
¹Biomedical Engineering, University of Michigan, Ann Arbor, MI, ²Internal Medicine, University of Michigan, Ann Arbor, MI, ³Human Genetics, University of Michigan, Ann Arbor, MI
*Purpose: As there is no assay to predict the risk of acute cellular allograft rejection (ACAR), clinicians rely on protocol graft biopsy and aggressive, one-size-fits-all…
2022 American Transplant Congress
Prediction of Waitlist Mortality in Liver Transplant Candidates: Do Time-Varying Models Help?
A. Kwong¹, W. Kim¹, D. Schladt², A. Wey², J. Snyder², A. Israni², J. Lake³
¹Stanford University, Stanford, CA, ²Hennepin Healthcare Research Institute, Minneapolis, MN, ³University of Minnesota, Minneapolis, MN
*Purpose: In the United States, priority on the liver transplant waitlist is determined by the model for end-stage liver disease (MELD)-Na, a score composed of…
2022 American Transplant Congress
Demographic Characteristics of VCA Candidates and Recipients in the U.S.
J. Wainright¹, L. Cartwright¹, A. Henderson¹, W. Cherikh¹, S. Booker¹, D. Klassen²
¹Research, UNOS, Richmond, VA, ²Office of the Chief Medical Officer, UNOS, Richmond, VA
*Purpose: As with other fields of transplantation, it is important to understand the populations VCA transplantation is serving.*Methods: This study used OPTN VCA waiting list…
2022 American Transplant Congress
HLA Alleles Add to Risk Stratification for CMV Infection in Renal Transplant Recipients
R. Patil¹, R. Prashar², M. Ramesh², A. Patel²
¹Wayne State University School of Medicine, Detroit, MI, ²Henry Ford Transplant Institute, Detroit, MI
*Purpose: Cytomegalovirus (CMV) is the most common viral infection that occurs after solid organ transplantation. The incidence of CMV infection or disease (I/d) varies based…
2022 American Transplant Congress
CD40 Expressed by FRC Regulates Lymph Node Structure and Function
M. W. Shirkey¹, L. Li¹, R. Abdi², J. S. Bromberg¹
¹University of Maryland School of Medicine, Baltimore, MD, ²Transplant Research Center, Harvard Medical School, Boston, MA
*Purpose: Fibroblastic reticular cells (FRC) support lymph node (LN) structure and can regulate T cell function through the CD40-CD40L pathway. Our previous work showed that…
2022 American Transplant Congress
A2/A2B to B Kidney Transplantation Outcomes: A Single-Center 5 Year Experience
A. El Chediak, S. Shawar, M. Fallahzadeh, I. Feurer, S. Rega, J. L. Triozzi, D. Shaffer
Vanderbilt University Medical Center, Nashville, TN
*Purpose: The new kidney allocation system (KAS) instituted in 2014 allowed organ procurement organizations to allocate A2/A2B to B candidates preferentially was meant to improve…
2022 American Transplant Congress
Pregnancy After Heart Transplant Does Not Negatively Impact Long Term Patient Survival
M. J. Moritz¹, D. Lee², C. Madu², S. Hossain³, L. A. Coscia⁴, S. Rao⁵, S. Constantinescu⁶
¹Surgery, Lehigh Valley Health Network, Allentown, PA, ²Cardiovascular Medicine, University of South Florida, Morsani College of Medicine, Tampa, FL, ³Data Analytics, University of South Florida, Muma College of Business, Tampa, FL, ⁴Transplant Pregnancy Registry International, Philadelphia, PA, ⁵Nephrology, University of Virginia Health System, Charlottesville, VA, ⁶Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA
*Purpose: To evaluate the impact of pregnancy on patient survival in heart transplant recipients (HTRs), we linked the Transplant Pregnancy Registry International (TPRI) dataset with…
2022 American Transplant Congress
Sirolimus Use Is Associated With An Improved Immune Response To Covid-19 Vaccination In Kidney Transplant Recipients
G. B. Perkins¹, M. Tunbridge², T. Salehi², C. Chai¹, C. M. Hope¹, P. Garcia-Valtanen¹, J. J. Singer³, P. R. Hurtado², S. C. Barry¹, B. Grubor-Bauk¹, P. Hissaria², S. J. Chadban³, P. Coates¹
¹University of Adelaide, Adelaide, Australia, ²Royal Adelaide Hospital, Adelaide, Australia, ³Royal Prince Alfred Hospital, Sydney, Australia
*Purpose: Kidney transplant recipients (KTRs) are highly vulnerable to severe COVID-19, however are poorly protected by vaccination. Additional vaccine doses have achieved limited improvements in…