ATC Abstracts

American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Identification of a Human B Cell State with Allogeneic Antigen Cross-Presenting Potential

    U. Bhatia, E. C. Guinan

    Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA

    *Purpose: B cells are known to play a significant role in allograft tolerance or rejection, largely determined by production of cytokines and antibodies that suppress…
  • 2022 American Transplant Congress

    Simultaneous Liver/ Kidney Transplant Reduces Both Donor Specific and Non-Donor Specific HLA Antibodies

    X. Zhang, S. Wisel, I. Kim, S. Jordan

    Cedars Sinai Medical Center, Los Angeles, CA

    *Purpose: Kidney allografts can be transplanted across strong donor specific antibody (DSA) barriers in simultaneous liver/kidney transplant (SLK) recipients. It is suggested that preformed DSAs…
  • 2022 American Transplant Congress

    The Impact of Yttium-90 Radioembolization on T Cell Phenotypes in Bridged to Transplant Hepatocellular Carcinoma Patients

    K. Nunez, T. Sandow, P. Thevenot, A. Cohen

    Ochsner Health System, New Orleans, LA

    *Purpose: Response to locoregional therapy (LRT) in hepatocellular carcinoma (HCC) impacts both progression-free survival (PFS) and bridge to transplant success. Yttrium-90 (Y90) is an effective…
  • 2022 American Transplant Congress

    Experience with Covid-19 Infection and Vaccination in Combined Kidney/HSCT Recipients

    M. Gibson1, D. Belshe1, G. Gregory1, S. Tanna1, M. Ison1, S. Ildstad2, J. R. Leventhal1

    1Northwestern University, Chicago, IL, 2University of Louisville, Louisville, KY

    *Purpose: Kidney transplant(KTx) recipients are at increased risk of COVID-19 related complications. KTx pts who have undergone therapy to induce tolerance are a unique cohort…
  • 2022 American Transplant Congress

    Validation of Shared T Cell Epitope Analysis as a Tool to Detect Preformed Donor-Reactive CD4+ Memory T-helper Cells

    T. Tomosugi1, K. Iwasaki2, S. Sakamoto3, K. Ftamura1, M. Okada1, T. Hiramitsu1, N. Goto1, S. Narumi1, Y. Watarai1, T. Kobayashi4

    1Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, 2Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagoya, Japan, 3Histocompatibility Laboratory, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, 4Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan

    *Purpose: Adaptive immunity creates immunological memory after the first response to a specific foreign antigen including HLA. During this response, adaptive immunity memorizes the molecular…
  • 2022 American Transplant Congress

    The Impact Of Covid-19 On Pediatric Organ Donation And Transplantation

    E. Lee1, X. Zhang2, G. Mazariegos3, T. Nakagawa4

    1Transplant Surgery, UPMC Childrens Hospital of Pittsburgh, Pittsburgh, PA, 2UPMC Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, 3Children's Hospital of Pittsburgh, Pittsburgh, PA, 4Department of Pediatrics, Division of Pediatric Critical Care Medicine, University of Florida College of Medicine, Jacksonville, FL

    *Purpose: The global COVID-19 pandemic has significantly altered delivery of healthcare. Hospital resource utilization has been impacted on multiple levels including solid organ transplantation and…
  • 2022 American Transplant Congress

    A New Algorithm Combining Donor Derived Cell-Free DNA Fraction and Quantity to Detect Kidney Transplant Rejection Using Molecular Diagnoses and Histology

    P. F. Halloran1, J. Reeve1, K. S. Madill-Thomsen1, N. Kaur2, E. Ahmed2, N. Al Haj Baddar2, Z. Demko2, N. Liang2, R. K. Swenerton2, B. G. Zimmermann2, P. Van Hummelen2, A. Prewett2, H. Tabriziani2, P. Gauthier2, P. R. Billings2

    1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2Natera, Inc., Austin, TX

    *Purpose: Donor derived cell-free DNA (dd-cfDNA) has been shown to be associated with allograft rejection, both histological and molecular (JASN, in press). Clinically available dd-cfDNA…
  • 2022 American Transplant Congress

    Survival Comparison of Simultaneous Pancreas-Kidney Transplant with Pancreas After Living-Donor Kidney Transplant by Wait Time and Organ Quality

    G. R. Lyden1, E. S. Helgeson2, E. B. Finger3, A. J. Matas3, J. J. Snyder4, D. M. Vock2

    1Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute; Division of Biostatistics, University of Minnesota, Mpls, MN, 2Div Biostatistics U MN, Mpls, MN, 3Dept Surg U MN, Mpls, MN, 4Hennepin Healthcare Research Institute, Mpls, MN

    *Purpose: The survival benefit of simultaneous pancreas-kidney (SPK) compared to pancreas after living-donor kidney (PALK) transplant is controversial. Wait times for SPK and donor risk…
  • 2022 American Transplant Congress

    Two Times or More Double-Filtration Plasmapheresis Increases the Risk of Bleeding During Kidney Transplantation

    T. Kanzawa, T. Tagisawa, M. Furusawa, K. Unagami, K. Kitajima, K. Omoto, H. Ishida, K. Tanabe, T. Takagi

    Urology, Tokyo Women's Medical University, Tokyo, Japan

    *Purpose: Double-filtration plasmapheresis (DFPP) is effective for desensitization in ABO incompatible and highly sensitized transplantation. In such cases, bleeding is difficult to stop due to…
  • 2022 American Transplant Congress

    Evaluation of Compliance and Efficacy with Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Tacrolimus in Kidney Transplant Recipients

    M. Nikirk1, J. Chen1, E. Tillman2

    1Indiana University Health, Indianapolis, IN, 2Indiana University School of Medicine, Indianapolis, IN

    *Purpose: The purpose of this study is to evaluate compliance and efficacy of The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 genotype guided tacrolimus…
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