Abstracts Archive - Page 66 of 1683 - ATC Abstracts

2022 American Transplant Congress
Outcomes of a Standardized Antibody-Mediated Rejection (AMR) Treatment Protocol in Heart Transplant Recipients (HTR)
J. Lee, T. Sam, J. Van Zyl, S. Mckean, L. Fuller, N. Wilson, A. Dao, R. Gottlieb, S. Hall, R. Patel
Baylor University Medical Center, Dallas, TX
*Purpose: AMR in HTR portends poor clinical outcomes. Reported mortality range between 20-50%, with higher rates reported for late AMR occurring at least 1 year…
2022 American Transplant Congress
RNA-Sequencing Analysis of Kidney Allografts Reveal Heightened NK Cell Activity in Chronic Active Antibody-Mediated Rejection
Y. Shah, E. Varma, S. Rahim, C. Li, C. Snopkowski, C. Hughes, D. M. Dadhania, S. Salvatore, S. V. Seshan, O. Elemento, M. Suthanthiran, T. Muthukumar
Weill Cornell Medicine, New York, NY
*Purpose: The role of NK cells is increasingly recognized in chronic active antibody mediated rejection (caABMR) of the kidney allograft. Treatment of caABMR is challenging…
2022 American Transplant Congress
Tissue Edema Following Hypothermic Machine Perfusion of a Small Animal Hind Limb Graft
D. Yoeli, Y. Wang, B. Li, J. Huang, S. Jain, Z. Wang, N. Nakra, N. Limon De La Rosa, K. Rampalski, A. Su, D. Mathes, K. Washington, E. Farkash, A. Jani, C. Huang
University of Colorado Anschutz Medical, Aurora, CO
*Purpose: The aim of this study was to evaluate the capability of preserving a small animal hind limb graft for 24 hours with hypothermic machine…
2022 American Transplant Congress
Gm2a Regulates Memory Cd8⁺ T Cell Activation and Differentiation
K. P. Tong¹, K. M. Baecher², C. R. Hartigan¹, M. Ford³
¹Emory University Transplant Center, Emory University, Atlanta, GA, ²Department of Surgery, Emory University, Atlanta, GA, ³Emory University, Atlanta, GA
*Purpose: In a clinical trial, patients who underwent kidney transplantation and were subsequently stable off tacrolimus immunosuppression exhibited increased Gm2a transcript in PBMC relative to…
2022 American Transplant Congress
BMI Trajectory and Attributable Risk of New Onset Hypertension Among Obese Living Kidney Donors
R. D. Reed¹, M. C. McLeod¹, P. A. MacLennan¹, V. Kumar¹, S. E. Brooks¹, A. G. Maynor¹, L. A. Stanford¹, G. A. Baker¹, C. A. Schinstock², J. R. Silkensen³, G. R. Roll⁴, D. L. Segev⁵, B. J. Orandi¹, C. E. Lewis⁶, J. E. Locke¹
¹Surgery, University of Alabama at Birmingham, Birmingham, AL, ²Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ³Medicine, Hennepin County Medical Center, Minneapolis, MN, ⁴Surgery, University of California San Francisco, San Francisco, CA, ⁵Surgery, Johns Hopkins University, Baltimore, MD, ⁶Epidemiology, University of Alabama at Birmingham, Birmingham, AL
*Purpose: Obesity increases hypertension risk in general and living kidney donor populations. Risk attributable to donation in the context of obesity and whether that risk…
2022 American Transplant Congress
Experience Using Intra-Operative Dialysis in Surgically Complex Liver Transplantation
M. Palascak¹, D. Arango¹, S. Yockelson¹, J. Koveleskie¹, D. Ganier¹, A. Cohen², H. Bohorquez²
¹Anesthesiology, Ochsner, New Orleans, LA, ²Surgery, Ochsner, New Orleans, LA
*Purpose: At our high-volume center, we often perform liver transplantation (LT) on surgically complex patients that includes re-transplantation, prior open liver resection, bariatric surgeries, extensive…
2022 American Transplant Congress
Implementing Clinical Decision Support Tools for Immunosuppressant Drug-Drug Interactions to Prevent Graft Failure
A. Yishak¹, S. Ledan², S. Mukherjee³, C. Chen², A. Ayoola², T. Kim², A. Olenik², K. Mullican², A. Henje², N. Lorence², L. Beckman²
¹MAPMG, Mc Lean, VA, ²Kaiser Permanente, Silver Spring, MD, ³MAPMG, Rockville, MA
*Purpose: Immunosuppressant drug-drug interactions can result in immunosuppressant toxicity or subtherapeutic levels causing rejection. If not identified and managed appropriately, these interactions may result in…
2022 American Transplant Congress
Polarized Il-6 Secretion from Lymphatic Endothelial Cells Promotes Treg Conversion to Extregs
V. Saxena¹, W. Piao¹, L. Li¹, M. W. Shirkey¹, R. Lakhan¹, S. Walden², K. L. Hippen², B. Blazar², J. S. Bromberg¹
¹University of Maryland School of Medicine, Baltimore, MD, ²University of Minnesota, Minneapolis, MN
*Purpose: Regulatory T cell (Treg) suppressor function and allograft protection depend on maintenance of transcription factor Foxp3 expression and lymphatic migration. Lymphatic endothelial cell (LEC)…
2022 American Transplant Congress
Donor-Derived IL-33 Plays a Critical Role in Lung Allograft Acceptance
Y. Guo¹, Z. Mei¹, M. Khalil¹, D. Li¹, A. Banerjee¹, A. Gelman², D. Kreisel², A. Krupnick¹
¹Department of Surgery, University of Maryland, Baltimore, Baltimore, MD, ²Washington University School of Medicine in St Louis, Saint Louis, MO
*Purpose: IL-33 is considered an alarmin secreted in response to tissue damage. While it is elaborated by the lung allograft as part of ischemia-reperfusion injury…
2022 American Transplant Congress
Cd80 on Effector T Cell Binds Pd-l1 on Lymphatic Endothelial Cells to Fine Tune Migration
W. Piao¹, V. Saxena¹, L. Li¹, K. Hippen², Y. Zhang², B. Blazar², I. Lape³, L. Riella³, J. Bromberg¹
¹Surgery, University of Maryland, Baltimore, MD, ²University of Minnesota, Minneapolis, MN, ³Harvard Medical School, Boston, MA
*Purpose: Antigen presenting cell (APC) CD80 trans-binds CD28 and CTLA4 on T cells, boosting or inhibiting immunity, respectively. CD80 has another ligand, Programmed Death-1 Ligand…