Abstracts Archive - Page 656 of 1683 - ATC Abstracts

2019 American Transplant Congress
Identification of Adult Liver Transplant Recipients Eligible to Participate in an Immunosuppression Withdrawal Trial Employing Non-Invasive Assessments of Allograft Status
J. Vionnet¹, R. Miquel¹, A. Douiri¹, M. Elstad¹, E. Kodela¹, A. Quaglia², J. Wall¹, P. Ruiz Martin¹, E. B. Riani³, J. Leithead⁴, A. Marshall², M. Navasa⁵, P. Ruiz⁵, J. Ferguson⁶, K. Simpson⁷, A. Pascher⁸, E. Jaeckel⁹, R. Bishop¹⁰, F. Nevens¹¹, S. Masson¹², A. Sanchez-Fueyo¹
¹King's College London, London, United Kingdom, ²Royal Free, London, United Kingdom, ³St-Luc, Brussels, Belgium, ⁴Addenbrookes, Cambridge, United Kingdom, ⁵Hospital Clinic, Barcelona, Spain, ⁶Queen Elizabeth, Birmingham, United Kingdom, ⁷Royal Infirmary, Edinburgh, United Kingdom, ⁸Charité, Berlin, Germany, ⁹Hannover Medical School, Hannover, Germany, ¹⁰Leeds NHS Trust, Leeds, United Kingdom, ¹¹UZ Leuven, Leuven, Belgium, ¹²Hepatology, Newcastle, United Kingdom
*Purpose: Liver Immunosuppression Free Trial (LIFT) is a multicentre international prospective randomised controlled trial of biomarker-guided immunosuppression withdrawal in adult liver transplant recipients who meet…
2019 American Transplant Congress
Inflammation and Fibrosis Are Observed in 34% of Clinically Stable Adult Liver Transplant Recipients
L. Sun¹, J. Levitsky², S. Feng³, A. Humar⁴, A. J. Demetris⁴, J. Emond⁵, A. Shaked⁶, G. Klintmalm⁷, K. Mason⁸, M. DesMarais¹, A. Priore⁹, N. Bridges⁹, B. E. Burrell¹⁰, S. Chandran³, J. Markmann¹¹
¹ITN, San Francisco, CA, ²Northwestern, Chicago, IL, ³UCSF, San Francisco, CA, ⁴UPMC, Pittsburg, PA, ⁵Columbia, New York, NY, ⁶UPenn, Philadelphia, PA, ⁷Baylor, Dallas, TX, ⁸Rho, Chapel Hill, NC, ⁹NIAID, Bethesda, MD, ¹⁰ITN, Bethesda, MD, ¹¹MGH, Boston, MA
*Purpose: OPTIMAL is a 7-center immunosuppression withdrawal (ISW) study in non-autoimmune, non-HCV adult liver transplant recipients ≥3 yrs post-transplant (tx) (NCT02533180). Subjects underwent a screening…
2019 American Transplant Congress
A Novel Protocol to Produce Massive Amounts of Autologous Thymus-Derived Treg Cells (ThyTreg) to Be Employed as Cellular Therapy in Heart Transplanted Children: A New Paradigm for the Prevention of Graft Rejection
E. Bernaldo de Quirós¹, R. López¹, V. Pérez¹, M. Clemente², J. Gil-Jaurena³, M. Camino⁴, N. Gil⁴, E. Panadero⁴, C. Medrano⁴, M. Pion¹, R. Correa-Rocha¹
¹Laboratory of Immune-regulation, Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Madrid, Spain, ²Cell Culture Unit, Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Madrid, Spain, ³Pediatric Cardiac Surgery Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ⁴Pediatric Cardiology Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain
*Purpose: Immune allograft rejection remains the main obstacle to successful transplants. Although transfer of regulatory T cells (Treg) has acquired growing interest in achieving indefinite…
2019 American Transplant Congress
Mismatched Antibody Epitopes and the Development of HLA-DQ De Novo DSA during Immunosuppression Withdrawal in Liver Transplant Recipients
V. Jucaud¹, A. Shaked², M. DesMarais³, P. Sayre⁴, S. Feng⁴, J. Levitsky⁵, M. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²University of Pennsylvania, Philadelphia, PA, ³Immune Tolerance Network, San Francisco, CA, ⁴University of California San Francisco, San Francisco, CA, ⁵Northern Western University, Chicago, IL
*Purpose: We recently described, in liver transplant (LT) recipients from the ITN030ST study, the development of de novo donor-specific HLA antibodies (dnDSA) and their impact…
2019 American Transplant Congress
Paradoxical Liver Simulated Allocation Model (LSAM) Projections for Changes to Waitlist Mortality under Acuity Circle Distribution Model
R. Lynch¹, K. Ross¹, S. Karp²
¹Emory, Atlanta, GA, ²Vanderbilt, Nashville, TN
*Purpose: In December 2018, the United Network for Organ Sharing (UNOS) board voted to change liver transplant distribution from Donor Service Areas (DSAs) to a…
2019 American Transplant Congress
Recipient Predictors of Post-Donation End Stage Renal Disease in Living Kidney Donors
J. Wainright¹, A. Robinson¹, A. Wilk¹, D. Klassen², W. Cherikh¹, L. Cartwright¹, D. Stewart¹
¹Research, UNOS, Richmond, VA, ²UNOS, Richmond, VA
*Purpose: We studied associations between kidney transplant recipient diagnosis and other factors and development of ESRD among related living kidney donors (LKDs).*Methods: Using OPTN listing…
2019 American Transplant Congress
Transplantation of Hepatitis C Virus Positive Donor Kidneys into Hepatitis C Negative Older Recipients
J. A. Graham¹, M. Ajaimy², J. Torabi¹, T. Powell³, J. Weiss⁴, T. Weinstein⁵, S. Greenstein¹, O. Andacoglu¹, A. Campbell⁶, J. Carrero¹, J. Lapponese¹, M. Kinkhabwala¹, E. Akalin², J. P. Rocca¹
¹Surgery, Montefiore Medical Center, Bronx, NY, ²Medicine, Montefiore Medical Center, Bronx, NY, ³Epidemiology and Psychiatry, Montefiore Medical Center, Bronx, NY, ⁴Medical Affairs, Montefiore Medical Center, Bronx, NY, ⁵Risk & Loss Prevention, Montefiore Medical Center, Bronx, NY, ⁶Pharmacy, Montefiore Medical Center, Bronx, NY
*Purpose: Patients awaiting transplantation are often at risk of developing life-threatening disease and complications. Older patients have a disproportionately higher risk of dropping out of…
2019 American Transplant Congress
EBV+ PTLD in the Modern Immunosuppression Era: Role of EBV Serology and DNAemia-Preliminary Data from CTOT-C06
O. M. Martinez¹, S. M. Krams¹, M. A. Robien², M. Lapasaran¹, S. D. Boyd¹, B. Armstrong³, C. Twist⁴, K. Weinberg¹, D. Gratzinger¹, B. Tan¹, M. Sever³, D. Ikle³, M. Brown², D. Bernstein¹, C. O. Esquivel¹
¹Stanford University Sch of Med, Stanford, CA, ²NIAID/NIH, Rockville, MD, ³Rho, Chapel Hill, NC, ⁴Roswell Park, Buffalo, NY
*Purpose: Post-transplant lymphoproliferative disorder (PTLD) remains a serious problem in the pediatric transplant population. The Clinical Trials of Organ Transplantation in Children (CTOT-C)-06 is an…
2019 American Transplant Congress
Specific Donor/Recipient HLA Disparities are Associated with Better Long-Term Kidney Allograft Survival among 4-, 5-, and 6-HLA (A/B/DR)-Mismatched Pairs
D. Bekbolsynov, H. Zhang, B. Mierzejewska, M. Rees, K. Xu, S. Stepkowski
University of Toledo, Toledo, OH
*Purpose: The vast majority of deceased donor kidneys are allocated without any consideration for the HLA disparities, which may improve or worsen the survival the…
2019 American Transplant Congress
The Influential Yet Highly Variable Role of Biopsy Findings on Kidney Offer Acceptance Decisions: An Organ Offer Simulation Study
D. Stewart¹, J. Rosendale¹, H. McGehee¹, I. Hall², G. Gupta³, K. Reddy⁴, B. Kasiske⁵, K. Andreoni⁶, D. Klassen¹
¹UNOS, Richmond, VA, ²Univ of Utah, Salt Lake City, UT, ³VCU, Richmond, VA, ⁴Mayo, Phoenix, AZ, ⁵HCMC, Minneapolis, MN, ⁶Univ of Florida, Gainesville, FL
*Purpose: The use of procurement biopsies (Bx) to assess kidney quality is controversial. ‘Biopsy findings’ is an often cited discard reason, yet the association between…